Comparison of optical coherence tomographic findings between Behcet disease
            patients with and without ocular involvement and healthy subjects

Karadağ, Ayşe Sevgi; Bi̇lgi̇n, Burak; Soylu, Merih

doi:10.5935/0004-2749.20170018

Cited by 19 publications

(18 citation statements)

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“…Previous studies have assessed ocular neural tissues in patients with BD using OCT and show a reduction in the retinal nerve fiber layer in patients with Neuro-Behçet’s disease and uveitis ( 21 , 46 ). More recently, even patients with BD without ocular disease have shown a significant reduction in the retinal nerve fiber layer, ganglion cell layer, and inner plexiform layer, indicative of sub-clinical retinal nerve degeneration ( 22 ). Our findings are consistent with previous clinical, histopathological and electrophysiological studies reporting peripheral nerve degeneration in BD ( 8 , 9 , 11 , 13 , 45 ).…”

Section: Discussionmentioning

confidence: 99%

“…In relation to eye involvement in BD, most studies have described an optic neuropathy and retinal pathology with maculopathy and retinal neovascularization ( 19 , 20 ). Studies using optical coherence tomography (OCT) have demonstrated a significant reduction in the thickness of the retinal nerve fiber layer ( 21 ), ganglion cell and inner plexiform layers in patients with BD ( 22 ), while another study showed an initial increase in the nerve fiber layer in those with a short duration of disease, with thinning in those with a longer duration of disease ( 23 ), certainly indicating retinal nerve fiber pathology in patients with BD.…”

Section: Introductionmentioning

confidence: 99%

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In Vivo Confocal Microscopic Evaluation of Corneal Nerve Fibers and Dendritic Cells in Patients With Behçet’s Disease

et al. 2018

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Central and peripheral nervous system involvement may occur during the course of Behçet’s disease (BD). In vivo corneal confocal microscopy (CCM) can detect corneal small fiber damage and immune cell density. The aim of this study was to assess central corneal sensitivity, corneal subepithelial nerve plexus morphology and dendritic cell (DC) density in patients with BD. Forty-nine consecutive patients with BD and 30 healthy control subjects were included in this cross-sectional study conducted at a tertiary referral university hospital. Central corneal sensitivity was measured using the contact corneal esthesiometer (Cochet-Bonnet; Luneau, France). The laser scanning CCM (Heidelberg, Germany) was used to quantify corneal nerve fiber density (NFD), nerve branch density (NBD), nerve fiber length (NFL), and DC density. There was a significant reduction in NFD (P = 0.001) and NFL (P = 0.031) and an increase in DC density (P = 0.038) in patients with BD compared to healthy controls, whereas corneal sensitivity (P = 0.066) and NBD (P = 0.067) did not differ significantly. There was no difference in corneal sensitivity, corneal nerve parameters, or DC density between BD patients with [n = 18 (36.7%)] and without a previous history of uveitis (P > 0.05 for all). Disease duration [median (IQR), 6.5 (4.0–14.5) years] correlated with corneal sensitivity (ρ = −0.463; P = 0.001) and NFD (ρ = −0.304; P = 0.034) and corneal sensitivity correlated with NFD (ρ = 0.411; P = 0.003) and NFL (ρ = 0.295; P = 0.039) in patients with BD. CCM demonstrates corneal sub-basal nerve fiber loss and increased DC density, providing a non-invasive ophthalmic means to identify peripheral neuropathy and inflammation in patients with BD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In Vivo Confocal Microscopic Evaluation of Corneal Nerve Fibers and Dendritic Cells in Patients With Behçet’s Disease

et al. 2018

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“…Since the retinal and choroidal microvasculature is particularly susceptible to systemic vascular changes, as observed in diseases such as hypertension and diabetes mellitus, it would be ideal for monitoring disease progression in SSc patients. Additionally, thicknesses of the choroid and retina have been suggested as potential inflammatory biomarkers for autoimmune diseases with a vascular component [7][8][9]. So far, choroidal and retinal abnormalities, such as those reported in SSc patients, have been evaluated by optical coherence tomography (OCT) and fluorescence angiography (FA) [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Correlation of retinal and choroidal microvascular impairment in systemic sclerosis

Rommel

Prangel

Prasuhn

et al. 2021

Orphanet J Rare Dis

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Purpose To investigate the correlation between retinal and choroidal microperfusion in patients with systemic sclerosis (SSc) using optical coherence tomography angiography (OCTA). Methods In this cross-sectional study SSc patients without clinical evidence of ocular involvement and healthy, age- and sex-matched volunteers were recruited. Participants underwent specific rheumatological and ophthalmological examinations, including optical coherence tomography (OCT) and OCTA. Retinal and choroidal thicknesses as well as perfusion of the retina and the choroidal sublayers were evaluated. Results A total of 15 SSc patients (30 eyes) with a median disease duration of 60 months and 15 matched, healthy controls (30 eyes) were recruited. OCT data revealed a significantly lower macular volume, as well as Sattler’s layer and Haller’s layer thickness in SSc patients compared to controls. In OCTA analysis, the perfusion of both retinal plexus as well as Sattler’s and Haller’s layer were significantly reduced in the SSc group. Patients with a disease duration of more than 60 months showed a statistically significant positive correlation between retinal and choroidal malperfusion, while those with a shorter disease duration did not. Conclusion OCTA analysis confirmed impairment of retinal and choroidal microperfusion in SSc patients, supporting the hypothesis of wide spreading vascular injury. In early stages, either the retinal or the choroidal perfusion seems to be involved, while later on, vascular impairment affects both tissues alike. Both, retinal and choroidal examinations should be considered as soon as the diagnosis of SSc is made, to avoid missing out on early alterations.

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“…Changes in its morphology have been suggested to be a useful biomarker of some systemic, 1 neurodegenerative, 2 and ocular diseases. 3 For example, the retinas of individuals with the autoimmune diseases systemic lupus erythematosus and Behcet's disease have been found to be thinner than those of healthy controls, 4,5 even when there was no clinically obvious ocular involvement. 4 Individuals with nonexudative age-related macular degeneration have been observed to have thinner retinas, 6 whereas various forms of macular edema intrinsically result in thickening of the central retina.…”

Section: Introductionmentioning

confidence: 99%

Macular Thickness Profile and Its Association With Best-Corrected Visual Acuity in Healthy Young Adults

Lee

Lingham

Alonso‐Caneiro

et al. 2021

Trans. Vis. Sci. Tech.

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To describe the thickness profiles of the full retinal and outer retinal layers (ORL) at the macula in healthy young adults, and associations with best-corrected visual acuity (BCVA). Methods: In total, 1604 participants (19-30 years) underwent an eye examination that included measurements of their BCVA, axial length, and autorefraction. The retinal thickness at the foveal pit and at the nine Early Treatment of Diabetic Retinopathy Study macular regions (0.5-mm radius around the fovea, and superior, inferior, temporal, and nasal quadrants of the inner and outer rings of the macula) were obtained using spectraldomain optical coherence tomography imaging. A custom program was used to correct for transverse magnification effects because of different axial lengths. Results: The median full retinal and ORL thicknesses at the central macula were 285 μm and 92 μm. The full retina was thinnest centrally and thickest at the inner macula ring, whereas the ORL was thickest centrally and gradually decreased in thickness with increasing eccentricity. There was no association between axial length and the full retinal or ORL thickness. Increased thicknesses of the full retina at the central macula was associated with better BCVA; however, the effect size was small and not clinically significant. Conclusions: This article mapped the full retinal and ORL thickness profile in a population-based sample of young healthy adults. Translational Relevance: Thickness values presented in this article could be used as a normative reference for future studies on young adults and in clinical practice.

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Comparison of optical coherence tomographic findings between Behcet disease patients with and without ocular involvement and healthy subjects

Abstract: SD-OCT was a useful and non-invasive tool for the detection of retinal nerve degeneration and choroidal changes in patients with Behcet disease even in the absence of ocular involvement.

Cited by 19 publications

References 0 publications

In Vivo Confocal Microscopic Evaluation of Corneal Nerve Fibers and Dendritic Cells in Patients With Behçet’s Disease

In Vivo Confocal Microscopic Evaluation of Corneal Nerve Fibers and Dendritic Cells in Patients With Behçet’s Disease

Correlation of retinal and choroidal microvascular impairment in systemic sclerosis

Macular Thickness Profile and Its Association With Best-Corrected Visual Acuity in Healthy Young Adults

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