2017
DOI: 10.2967/jnumed.117.197665
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Comparison of PET/CT with Sequential PET/MRI Using an MR-Compatible Mobile PET System

Abstract: The current study tested a newly developed flexible PET (fxPET) scanner prototype. This fxPET system involves dual arc-shaped detectors based on silicon photomultipliers that are designed to fit existing MRI devices, allowing us to obtain fused PET and MR images by sequential PET and MR scanning. This prospective study sought to evaluate the image quality, lesion detection rate, and quantitative values of fxPET in comparison with conventional whole-body (WB) PET and to assess the accuracy of registration. Seve… Show more

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Cited by 12 publications
(4 citation statements)
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References 18 publications
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“…Mean misregistration of fxPET/MRI was below 3 mm in all margins, comparable to the result of a prior phantom study (around 2 mm) [25]. Location information from optical camera reflecting head position change was used for better registration and conventional rigid body transformation has also been effective for registration of brain A Self-archived copy in Kyoto University Research Information Repository https://repository.kulib.kyoto-u.ac.jp images [30].…”
Section: Discussionsupporting
confidence: 74%
“…Mean misregistration of fxPET/MRI was below 3 mm in all margins, comparable to the result of a prior phantom study (around 2 mm) [25]. Location information from optical camera reflecting head position change was used for better registration and conventional rigid body transformation has also been effective for registration of brain A Self-archived copy in Kyoto University Research Information Repository https://repository.kulib.kyoto-u.ac.jp images [30].…”
Section: Discussionsupporting
confidence: 74%
“…Sequential PET/MRI systems have been constructed by either combining two clinical scanners for human imaging 37,38 or by combining two preclinical scanners. [39][40][41] In this investigation, we constructed and tested a sequential, preclinical PET/MRI system consisting of an MR-compatible, preclinical PET scanner constructed at West Virginia University combined with a specialized MRI coil designed for use with a clinical 3 T MRI scanner.…”
Section: Discussionmentioning
confidence: 99%
“…Simultaneous PET and MRI of the brain adds to the value of the examination. This growing area will be very significant and will demonstrate that other approaches, such as sequential PET followed by MRI where the technology of PET is positioned just outside the entrance bore of the MRI, are not competitive [79]. Simultaneity allows a) the combination of fMRI and PET to determine the directionality of brain connections, which cannot be done without simultaneous acquisition [80], b) the potential to significantly lessen the invasiveness of many PET procedures by eliminating the use of arterial sampling [81, 82], and c) removal of motion artifact in the PET data [18].…”
Section: Equipment Specificationsmentioning
confidence: 99%