Comparison of prognostic, clinical, and renal histopathological characteristics of overlapping idiopathic membranous nephropathy and IgA nephropathy versus idiopathic membranous nephropathy

Chen, Xinxin; Chen, Yu; Shi, Ke‐Qing; Lv, Yinqiu; Tong, Huan; Zhao, Guangju; Chen, Chaosheng; Chen, Bin; Li, Duo; Lu, Zhongqiu

doi:10.1038/s41598-017-11838-1

Cited by 17 publications

(23 citation statements)

References 24 publications

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“…In total, 506 patients with IMN were identified between 11 September 2006, and 25 November 2015, in The First Affiliated Hospital of Wenzhou Medical University. The diagnostic criteria for IMN and exclusion criteria were same as those used in our previous study [16]. The flowchart detailing the patient selection process is displayed in Figure 1.…”

Section: Methodsmentioning

confidence: 99%

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Baseline proteinuria level is associated with prognosis in idiopathic membranous nephropathy

Chen

Ding

et al. 2019

Renal Failure

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Objectives: This study aimed to investigate the unique prognostic, clinical, and renal histopathological characteristics of patients with idiopathic membranous nephropathy (IMN) with different levels of proteinuria. Methods: This retrospective observational study included 190 IMN patients with low levels of proteinuria (low group), 193 IMN patients with medium levels of proteinuria (medium group), and 123 IMN patients with high levels of proteinuria (high group) treated between September 2006 and November 2015. Prognostic and baseline clinical and histopathological data were compared among the three groups. Poor prognostic events included the occurrence of a persistent 50% reduction in estimated glomerular filtration rate (eGFR), end-stage renal disease, or all-cause mortality. Results: The severity of clinical symptoms and laboratory indices, such as blood pressure; extent of edema and hematuria; levels of fibrinogen, immunoglobulin (Ig)-G, complement (C)-4, total protein, albumin (ALB), and serum creatinine (SCr); and eGFR increased with increasing proteinuria (all p < .001). Based on renal histopathology, the extent of segmental sclerosis and balloon adhesion and renal interstitial lesion stage also increased in severity with increasing proteinuria (all p < .001). The Kaplan–Meier analysis showed that compared with patients with low and medium levels of proteinuria, patients with high levels of proteinuria had significantly lower cumulative poor event-free renal survival rates ( p = .0039). Conclusions: Baseline proteinuria level is indicative of prognosis in IMN patients; the greater the extent of proteinuria is, the worse the prognosis.

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Section: Methodsmentioning

confidence: 99%

“…The baseline date for the analysis was the same as the date of biopsy, which also marked the start of the follow-up period. The baseline clinical data and pathological indicators were collected as in our previous study [16].…”

Section: Methodsmentioning

confidence: 99%

Baseline proteinuria level is associated with prognosis in idiopathic membranous nephropathy

Chen

Ding

et al. 2019

Renal Failure

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“…according to primary diseases, Mn can be categorized into idiopathic membranous nephropathy (iMn) and secondary membranous nephropathy (SMn), while iMn accounts for approximately 80% of the total incidence of Mn (7). in recent years, the morbidity of IMN in China significantly increased from 6.48% between 1997 and 1999 to 22.79% between 2009 and 2011 (8)(9)(10)(11). The clinical prognosis of iMn varies greatly.…”

Section: Introductionmentioning

confidence: 99%

Advances of the experimental models of idiopathic membranous nephropathy (Review)

et al. 2020

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idiopathic membranous nephropathy (iMn) is one of the main types of chronic kidney disease in adults and one of the most common causes of end-stage renal disease. in recent years, the morbidity of iMn among primary glomerular diseases has markedly increased, while the pathogenesis of the disease remains unclear. To address this, a number of experimental models, including Heymann nephritis, anti-thrombospondin type-1 domain-containing 7a antibody-induced iMn, cationic bovine serum albumin, anti-human podocyte antibodies and zymosan-activated serum-induced c5b-9, have been established. This review comprehensively summarized the available animal and cell models for iMn. The limitations and advantages of the current models were discussed and two improved models were introduced to facilitate the selection of an appropriate model for further studies on iMn. Contents 1. introduction 2. rat models of iMn 3. Mouse models of iMn 4. limitations and advantages of the animal models 5. cell models of iMn 6. limitations and advantages of the cell models 7.

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“…The study carried out by Chen et al reported that old age and high blood indices were significantly correlated with poor prognosis of patients with iMN. 24 Therefore, timely and effective treatment and medical care is particularly important for older MN patients.…”

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The clinicopathological features of patients with membranous nephropathy

Zhu

Han

Zhang

et al. 2018

IJNRD

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Background: Membranous nephropathy (MN) represents a distinct glomerular disease which has been considered as a major cause of nephrotic syndrome (NS) in adults. Evidences show that the clinicopathological features of MN are various among MN cases. This study aimed to summarize and analyze the clinicopathological features of patients with MN. Methods: A total of 231 MN patients were recruited in this study. Their clinical and pathological features were collected and analyzed according to their age, gender, pathological stages, and anti-phospholipase A2 receptor (anti-PLA2R) antibodies tests. Results: Among the 231 MN cases, the ratio of male to female was 1.47 and the mean age was 47.43±14.32 years. Altogether, 163 (70.6%) cases were positive for NS. Their serum antiPLA2R, body mass index, total cholesterol, triglyceride, low density lipoprotein cholesterol, D2, IgA, and IgE were increased, but IgG was decreased. The majority of the patients were middle aged and old aged. In addition, the pathological stage was significantly correlated with gender (P=0.038), creatinine, (P=0.021) and IgE (P=0.003). A total of 74.9% MN patients were found to be positive for anti-PLA2R antibodies, and they were more likely to have abnormal serum indices. Conclusion:The major clinicopathological characteristics of MN patients are summarized in this study. Male and elder MN cases are likely to have rapid disease progression. Advanced pathological stages and being positive for anti-PLA2R antibodies may be potential indicators for disease activity of MN.

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Comparison of prognostic, clinical, and renal histopathological characteristics of overlapping idiopathic membranous nephropathy and IgA nephropathy versus idiopathic membranous nephropathy

Cited by 17 publications

References 24 publications

Baseline proteinuria level is associated with prognosis in idiopathic membranous nephropathy

Baseline proteinuria level is associated with prognosis in idiopathic membranous nephropathy

Advances of the experimental models of idiopathic membranous nephropathy (Review)

The clinicopathological features of patients with membranous nephropathy

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