Comparison of protocols efficacy in poor responders: differences in oocytes/embryos competence with different protocols, a retrospective study

Manno, Massimo; Tomei, Francesco; Cervi, Marta; Favretti, Cristina; Adamo, Valter

doi:10.1016/j.fertnstert.2008.06.001

Cited by 4 publications

(1 citation statement)

References 25 publications

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“…Previous studies have shown that GnRH antagonist or agonist flare-up protocols might be better than the standard long protocol in these patients [6]. The aim of this prospective, randomized-controlled study was to compare the effects of gonadotropin-releasing hormone antagonist and agonist microdose flare-up protocols on cycle outcomes and pregnancy rates in poor responder patients.…”

Section: Introductionmentioning

confidence: 99%

The comparison of microdose flare up and flexible antagonist protocols in poor responders undergoing IVF treatment: A prospective randomized controlled trial

Özdoğan¹,

Özdeğirmenci²,

Dilbaz³

et al. 2018

Journal of Surgery and Medicine

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Section: Introductionmentioning

confidence: 99%

The comparison of microdose flare up and flexible antagonist protocols in poor responders undergoing IVF treatment: A prospective randomized controlled trial

Özdoğan¹,

Özdeğirmenci²,

Dilbaz³

et al. 2018

Journal of Surgery and Medicine

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Depot GnRH Agonists in COH for ART

Allahbadia

Merchant

2016

Ovarian Stimulation Protocols

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Effects of Different Exposure Days to Gonadotropin-Releasing Hormone Agonist (GnRH-a) on Live Birth Rates in the Depot GnRH-a Protocol: A Retrospective Analysis of 7007 Cycles

Song

Liu

et al. 2021

Med Sci Monit

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Background In controlled ovarian hyperstimulation protocols worldwide, depot gonadotropin-releasing hormone agonist (GnRH-a) pretreatment is generally used for pituitary desensitization. The delay between the GnRH-a administration and starting gonadotropin treatment varies greatly, from 25 to 60 days. However, the association between exposure days to GnRH-a before the onset of gonadotropin administration and the clinical outcomes remains unknown. Material/Methods This retrospective study included 7007 patients who underwent fresh embryo transfers between February 2016 and July 2019. The duration of pituitary downregulation was categorized into 3 groups: group 1, ≤30 days; group 2, 31–35 days; and group 3, ≥36 days. The rates of live birth were compared as the main outcome measure. Logistic regression analysis was also performed after controlling for a range of confounders. Results The number of patients in groups 1, 2, and 3 was 2001, 2824, and 2182, respectively. Group 3 (≥36 days) had a noticeably higher live birth rate (48.1%) than the other 2 groups (42.6% and 43.9%, P =0.001). The rate of live birth was remarkably enhanced in group 3 (adjusted odds ratio: 1.264, 95% confidence interval: 1.098, 1.455, P =0.001) after controlling for confounders, while the difference was not found in group 2 ( P =0.512) compared with group 1. Conclusions In the depot GnRH-a protocol, live birth rates are higher among patients needing a longer time to achieve the goal of pituitary downregulation.

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Comparison of protocols efficacy in poor responders: differences in oocytes/embryos competence with different protocols, a retrospective study

Cited by 4 publications

References 25 publications

The comparison of microdose flare up and flexible antagonist protocols in poor responders undergoing IVF treatment: A prospective randomized controlled trial

The comparison of microdose flare up and flexible antagonist protocols in poor responders undergoing IVF treatment: A prospective randomized controlled trial

Depot GnRH Agonists in COH for ART

Effects of Different Exposure Days to Gonadotropin-Releasing Hormone Agonist (GnRH-a) on Live Birth Rates in the Depot GnRH-a Protocol: A Retrospective Analysis of 7007 Cycles

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