Comparison of ramosetron with ondansetron for prevention of postoperative nausea and vomiting in patients undergoing gynaecological surgery

Kim, S.I.; Baek, Young Hee; Ok, Si Young

doi:10.1093/bja/aep209

Cited by 73 publications

(79 citation statements)

References 19 publications

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“…[13] Headache and dizziness are the most common side effects of 5 HT-3 receptor antagonists. [14] No statistically significant difference was found in the incidence of adverse effects in both groups in our study which is similar as found by Fujji et al [13] and Kim et al [15] In conclusion, both Ondansetron and Granisetron were equally effective on preventing PONV in early postoperative period in patients undergoing gynaecological surgery under spinal anesthesia. In the late postoperative period, however, Granisetron was better with lessincidence of PONV and less need for rescue antiemetic.…”

Section: Resultssupporting

confidence: 89%

Comparative Efficacy of Ondansetron Versus Granisetron to Prevent Perioperative Nausea and Vomiting in Patients undergoing Gynaecological Surgery under Spinal Anaesthesia

Makker¹,

Bhardwaj²,

Singh³

et al. 2017

International Journal of Medical and Dental Sciences

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Section: Resultssupporting

confidence: 89%

Comparative Efficacy of Ondansetron Versus Granisetron to Prevent Perioperative Nausea and Vomiting in Patients undergoing Gynaecological Surgery under Spinal Anaesthesia

Makker¹,

Bhardwaj²,

Singh³

et al. 2017

International Journal of Medical and Dental Sciences

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“…There are several reports that Ramosetron was as effective as or even more effective than the older 5-HT3 receptor for the prevention of PONV during 0-24 h after anaesthesia (Kim SI, et al). [17] Furthermore, the antiemetic effect of Ramosetron can last up to 48 hours (Fujii Y et al). [18] The differences in effectiveness between the older 5-HT3 receptor antagonist and Ramosetron may be related to the longer elimination half-life and higher receptor affinity (pKi=8.5) of Ramosetron.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Study of Granisetron, Ramosetron and Palonosetron as Antiemetics in Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgeries

Yatoo¹,

Mahotra²,

Mehta³

et al. 2016

jemds

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“…Similarly, Kim et al demonstrated that ramosetron 0.3 mg was effective as ondansetron 8 mg, given i.v. before induction of anesthesia, in reducing the incidence of PONV [44].…”

Section: Yoshitaka Fujiimentioning

confidence: 99%

Management of Postoperative Nausea and Vomiting in Women Undergoing Major Gynecological Surgery: A Review and Update

Fujii

2011

CDTH

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Postoperative nausea and vomiting (PONV) are distressing and frequent adverse events associated with anesthesia and surgery, with a high incidence after major gynecological surgery (e.g., abdominal hysterectomy). Numerous antiemetics have been studied for the prevention and treatment of PONV after this surgical procedure.Most of the published trials indicate the improved prevention of PONV by avoiding risk factors and/or by using antiemetic therapy in women undergoing major gynecological surgery. Pharmacological approaches include phenothiazines (e.g., perphenazine), butyrophenones (e.g., droperidol), benzamides (e.g., metoclopramide), antihistamines (e.g., cyclizine), proppofol, dexamethasone, ephedrine, serotonin receptor antagonists (e.g., ondansetron, granisetron) and neurokinin-1 receptor antagonists (e.g., aprepitant). None of the currently available antiemetics is entirely effective, perhaps because most of them act through the blockade of one type of receptor. There is a possibility that combined antiemetics with different sites of activity would be more effective than one drug alone preventing PONV. Combination antiemetic regimens (e.g., ondansetron plus droperidol) are highly effective in the prevention of PONV. As non-pharmacological therapy, acupressure and acupuncture at the P6 (Nei-Kuwan) point are effective for preventing PONV. For the treatment of established PONV, granisetron is more effective than droperidol or metoclopramide.In the management of PONV after major gynecological surgery, the benefits and risks of these clinical strategies should be considered.

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Comparison of ramosetron with ondansetron for prevention of postoperative nausea and vomiting in patients undergoing gynaecological surgery

Abstract: Ramosetron 0.3 mg i.v. was as effective as ondansetron 8 mg i.v. in decreasing the incidence of PONV and reducing nausea severity in female patients during the first 24 h after gynaecological surgery.

Cited by 73 publications

References 19 publications

Comparative Efficacy of Ondansetron Versus Granisetron to Prevent Perioperative Nausea and Vomiting in Patients undergoing Gynaecological Surgery under Spinal Anaesthesia

Comparative Efficacy of Ondansetron Versus Granisetron to Prevent Perioperative Nausea and Vomiting in Patients undergoing Gynaecological Surgery under Spinal Anaesthesia

A Comparative Study of Granisetron, Ramosetron and Palonosetron as Antiemetics in Prevention of Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgeries

Management of Postoperative Nausea and Vomiting in Women Undergoing Major Gynecological Surgery: A Review and Update

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