Comparison of sentinel lymph node biopsy guided by blue dye with or without indocyanine green in early breast cancer

Shen, Songjie; Xu, Qianqian; Zhou, Yidong; Mao, Feng; Guan, Jinghong; Sun, Qiang

doi:10.1002/jso.25058

Cited by 30 publications

(38 citation statements)

References 13 publications

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“…ICG, a novel technique for SLNB, is increasingly used in clinical practice. The SLNB detection rate with ICG alone ranges from 93.1 to 100%, for 1.5-5.4 sentinel lymph nodes sampled per patient [5, 6, 11, 16–18, 20, 21]. The combined use of the conventional blue dye with ICG fluorescence could improve SLN localization and potentially reduce surgical time [22–24].…”

Section: Discussionmentioning

confidence: 99%

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Preliminary study of contrast-enhanced ultrasound in combination with blue dye vs. indocyanine green fluorescence, in combination with blue dye for sentinel lymph node biopsy in breast cancer

Zhou

Mao

et al. 2019

BMC Cancer

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Background This preliminary study aimed to examine the feasibility of sentinel lymph node biopsy (SLNB) using contrast-enhanced ultrasound (CEUS) vs. indocyanine green fluorescence (ICG), combined with blue dye in patients with breast cancer. Methods This was a retrospective study of consecutive female patients with invasive stage I-III (based on pre-operative physical examination and imaging) primary breast cancer at the Peking Union Medical College Hospital between 01/2013 and 01/2015 who underwent preoperative SLNB by ICG + blue dye or CEUS + blue dye. The numbers of detected SLNs, detection rates, and recurrence-free survival (RFS) rates were compared between the two groups. Results A total of 443 patients were included. The detection rates of SLNs in the CEUS + blue dye and ICG + blue dye groups were 98.4 and 98.1%, respectively (P = 0.814). The average numbers of SLNs detected per patient showed no significant difference between the two groups (3.06 ± 1.33 and 3.12 ± 1.31 in the CEUS + blue dye and ICG + blue dye groups, respectively; P = 0.659). After a median follow-up of 46 months, five patients in the CEUS + blue dye group and 15 in the ICG + blue dye group had recurrence. RFS rates showed no significant difference (P = 0.55). Conclusion This preliminary study suggests that CEUS + blue dye and ICG + blue dye are both feasible for SLN detection in breast cancer.

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Section: Discussionmentioning

confidence: 99%

“…Therefore, new techniques are being developed for SLNB. Among them, indocyanine green fluorescence (ICG) and contrast-enhanced ultrasound (CEUS) have some advantages [5, 6, 9–21]. Recent studies confirmed that ICG or CEUS alone is feasible and safe for SLNB.…”

Section: Introductionmentioning

confidence: 99%

Preliminary study of contrast-enhanced ultrasound in combination with blue dye vs. indocyanine green fluorescence, in combination with blue dye for sentinel lymph node biopsy in breast cancer

Zhou

Mao

et al. 2019

BMC Cancer

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“…Recently, there is a shift in practice toward the use of ICG, a fluorescent dye as an optical tracer. ICG does not stain the injection site under white light and the fluorescent signal can penetrate through overlying soft tissue (typically to a maximum of 1 cm, which can be increased by compression of overlying tissue), facilitating the intraoperative localization of the SN . There is a requirement for a near‐infrared camera to visualize the fluorescent dye during surgery.…”

Section: Recommendationsmentioning

confidence: 99%

Surgical consensus guidelines on sentinel node biopsy (SNB) in patients with oral cancer

et al. 2019

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Background The eighth international symposium for sentinel node biopsy (SNB) in head and neck cancer was held in 2018. This consensus conference aimed to deliver current multidisciplinary guidelines. This document focuses on the surgical aspects of SNB for oral cancer. Method Invited expert faculty selected topics requiring guidelines. Topics were reviewed and evidence evaluated where available. Data were presented at the consensus meeting, with live debate from panels comprising expert, nonexpert, and patient representatives followed by voting to assess the level of support for proposed recommendations. Evidence review, debate, and voting results were all considered in constructing these guidelines. Results/Conclusion A range of topics were considered, from patient selection to surgical technique and follow‐up schedule. Consensus was not achieved in all areas, highlighting potential issues that would benefit from prospective studies. Nevertheless these guidelines represent an up‐to‐date pragmatic recommendation based on current evidence and expert opinion.

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“…ICG requires the near-infrared light source of the fluorescent vascular imaging system to be excited in real time, and the imaging device is used to observe the subcutaneous lymphatic drainage pathway to mark the SLN. 21 Superparamagnetic iron oxide is represented by mononuclear macrophages in the lymphatic system. Through the action of an external magnetic field, iron oxide produces magnetism to achieve its tracking effect.…”

Section: Discussionmentioning

confidence: 99%

Nonliposuction Endoscopic Sentinel Lymph Node Biopsy Through the Periareolar Incision

Liang

Shuangta

2020

Surg Innov

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Background. Sentinel lymph node biopsy (SLNB) has been an alternative to axillary lymph node dissection as a standard procedure for breast cancer patients with clinically negative lymph nodes. Endoscopic technique has been developed for over 20 years but remains to be mastered by a slice of surgeons. Suction and squeezing in the liposuction endoscopic procedures may increase risk of local recurrence and metastasis. In this study, we present our method of SLNB procedure through the periareolar incision which improves the shape of the breast-conserving surgery. Patients and Procedures. Twenty-eight breast cancer patients with clinically negative lymph nodes received this procedure. Methylene blue dye and technetium-99m sulfur colloid were used to be the tracker of sentinel lymph nodes (SLNs). Periareolar incision was the main surgical technique. The STORZ HD endoscopic system and some special instruments were used during the operation. Results. SLNs can be accurately located and biopsied under an endoscope without additional incisions. The SLNs detection rate, sensitivity, and false-negative rate are 88%, 80%, and 11.1%, respectively. And, the complications such as paresthesia and upper limb lymphedema are similar compared with traditional breast-conserving surgery (10.7% vs 9.8% and 7.1% vs 7.8%). Conclusion. Endoscopic technique can be used to accurately assess the status of SLNs in patients with breast cancer. Nonliposuction endoscopic breast-conserving surgery is one of the safe and alternative surgical procedures for early breast cancer.

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Comparison of sentinel lymph node biopsy guided by blue dye with or without indocyanine green in early breast cancer

Abstract: The combined method achieved a higher identification rate and lower rate of axillary recurrence compared to the blue dye alone method.

Cited by 30 publications

References 13 publications

Preliminary study of contrast-enhanced ultrasound in combination with blue dye vs. indocyanine green fluorescence, in combination with blue dye for sentinel lymph node biopsy in breast cancer

Preliminary study of contrast-enhanced ultrasound in combination with blue dye vs. indocyanine green fluorescence, in combination with blue dye for sentinel lymph node biopsy in breast cancer

Surgical consensus guidelines on sentinel node biopsy (SNB) in patients with oral cancer

Nonliposuction Endoscopic Sentinel Lymph Node Biopsy Through the Periareolar Incision

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