Comparison of Serum Nitric Oxide, Malondialdehyde Levels, and Antioxidant Enzyme Activities in Behçet’s Disease with and without Ocular Disease

Aydın, Erdinç; Söğüt, Sadık; Özyurt, Hüseyın; Özuğurlu, Fikret; Akyol, Ömer

doi:10.1159/000077332

Cited by 17 publications

(9 citation statements)

References 25 publications

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“…reported that serum NO levels are not significantly changed in patients with BD and its subtypes,[29] whereas others reported decreased NO levels in the serum of BD patients. [3016] Orem et al .…”

Section: Discussionmentioning

confidence: 99%

Assessment of serum homocysteine, endothelin-1, and nitric oxide levels in behçet′s disease

2010

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Background:Some prominent features of Behçet’s disease (BD) are arterial and venous thromboses as a result of endothelial dysfunction. Hyperhomocysteinemia is responsible for vascular endothelial injury due to an increased frequency of thrombogenesis. Endothelin-1 (ET-1) is a vasoconstrictor whereas nitric oxide (NO) is an endothelial vasorelaxing peptide that is responsible for the inhibition of platelet adhesion.Aim:To evaluate serum levels of homocysteine (Hcy) and determine whether hyperhomocysteinemia is considered as a contributing risk factor for venous and arterial thromboses of BD, and to correlate serum levels of ET-1 and NO with disease activity.Materials and Methods:We measured serum levels of Hcy, ET-1, and nitrite (NO2−) in 25 patients who fulfilled the criteria of the International Study Group for BD, and compared them to those of 15 healthy control subjects. Levels of Hcy and ET-1 were measured by using enzyme-linked immunosorbent assay (ELISA), whereas serum nitrite (NO2−) levels were measured by using Griess reaction as an indicator for NO production. All the patients were screened for a history of venous thrombosis and subdivided into thrombotic and nonthrombotic subgroups according to their thrombotic history. Patients with BD were divided into two subgroups, active and inactive, according to their clinical and laboratory findings.Results:There were significant increases in serum levels of Hcy, ET-1, and nitrite in BD patients compared to those in controls. There was a significant increase in serum Hcy levels in thrombotic compared to nonthrombotic subgroups. Positive correlations were detected between the serum ET-1 and nitrite levels with disease activity in BD patients.Conclusion:Hyperhomocysteinemia may play some role in the development of venous and arterial thromboses in BD. Increased NO production might ave critical biological activities that are relevant to pathological events in the active period of the disease.

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Section: Discussionmentioning

confidence: 99%

Assessment of serum homocysteine, endothelin-1, and nitric oxide levels in behçet′s disease

2010

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“…Oxidative stress is also associated with other autoimmune diseases, such as scleroderma, type 1 diabetes mellitus, and Behçet's disease (21)(22)(23). However, the exact relationship between these two situations is still undefined.…”

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confidence: 99%

Increased levels of autoantibodies against catalase and superoxide dismutase associated with oxidative stress in patients with rheumatoid arthritis and systemic lupus erythematosus

Mansour

Lassoued

Gargouri

et al. 2008

Scandinavian Journal of Rheumatology

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“…In another study, which investigated the oxidant-antioxidant status in whole blood from BD and controls, GPx was found to be decreased similarly to the previous paper. 8 Aydin et al 24 found increased malondialdehyde levels, decreased GPx activity and non-significant changes in SOD activity in the serum of the patients. SOD activity was demonstrated to be increased in erythrocyte from BD patients in another study.…”

Section: Discussionmentioning

confidence: 95%

Genetic Polymorphism of Manganese Superoxide Dismutase in Behçet’s Disease

Yılmaz

Yağcı

et al. 2016

Arch Rheumatol

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Objectives: This study aims to investigate the genetic association between single nucleotide mutation in mitochondrial manganese superoxide dismutase and a Behçet's disease (BD) population by using molecular techniques. Patients and methods: Ninety-three BD patients (45 males, 48 females; mean age 33.15±8.99 years; range 17 to 65 years) and 125 controls (58 males, 67 females; mean age 28.33±7.31 years; range 18 to 62 years) were genotyped by polymerase chain reaction-restriction fragment length polymorphism method. The genotypic distributions in BD patients and controls were consistent with the Hardy-Weinberg equilibrium. Results: Significant differences were observed between BD patients and controls in terms of genotypic distribution. Frequencies of alanine (Ala)/Ala, Ala/valine (Val), and Val/Val were 14.0% (n=13), 45.2% (n=42), and 40.9% (n=38) in BD patients and 21.6% (n=27), 53.6% (n=67), and 24.8% (n=31) in controls, respectively (p=0.033). Conclusion:The Val/Val genotype of the manganese superoxide dismutase gene is associated with the physiopathology of BD in a group of Turkish patients.Keywords: Behçet's disease; manganese superoxide dismutase; polymerase chain reaction-restriction fragment length polymorphism; polymorphism.Behçet's disease (BD) is a chronic, multi-systemic, relapsing, and inflammatory disorder characterized by ocular manifestations, in particular. 1 It is also characterized by uveitis, recurrent oral ulceration, genital ulceration, and skin lesions. BD exists worldwide, but it is relatively more widespread in Middle Eastern and East Asian countries including Japan. 2 The effect of autoimmune response and genetic factors on etiology of BD was well established. 2 However, the etiologic mechanisms underlying this vascular disease have not been well understood yet. Reactive oxygen species (ROS) have been hypothesized to play an important role in BD. Evidence from several studies suggests that neutrophils from patients with BD generate high levels of ROS and then this stress causes endothelial cell lysis in vitro. [3][4][5] On the other hand, different data reported in the literature show a variation for the activities of antioxidant enzymes in BD: erythrocyte superoxide dismutase (SOD) activity was found to be increased, 4,6,7 unchanged, 8 and decreased, 5,9

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Comparison of Serum Nitric Oxide, Malondialdehyde Levels, and Antioxidant Enzyme Activities in Behçet’s Disease with and without Ocular Disease

Cited by 17 publications

References 25 publications

Assessment of serum homocysteine, endothelin-1, and nitric oxide levels in behçet′s disease

Assessment of serum homocysteine, endothelin-1, and nitric oxide levels in behçet′s disease

Increased levels of autoantibodies against catalase and superoxide dismutase associated with oxidative stress in patients with rheumatoid arthritis and systemic lupus erythematosus

Genetic Polymorphism of Manganese Superoxide Dismutase in Behçet’s Disease

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