Comparison of static versus pulsatile preservation of matched-paired kidneys

Gage, Fred; Ali, M.; Alijani, M.R.; Aquino, A; Barhyte, Diana Young; Callender, Clive O.; Colonna, John O.; Currier, C; Fernandez-Bueno, Carlos; Jonsson, Johann; Kowalski, Adam; Romolo, Joseph L.; Sasaki, Takaya; Shaver, Timothy R.; Swanson, S. John; Light, Jimmy A.

doi:10.1016/s0041-1345(97)01056-7

Cited by 15 publications

(15 citation statements)

References 3 publications

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“…Numerous papers indicate a dependency of DGF incidence on the mode of storage (24)(25)(26)(27)(28). DGF was found to appear in 20-84.6% of recipients of CS-stored kidneys and 12-80% of recipients of MP-stored grafts (29)(30)(31)(32). In our series, the incidence of delayed graft function of machine-perfused grafts did not differ significantly from that of CS-stored kidneys, although MP kidneys had significantly longer preservation times.…”

Section: Discussionmentioning

confidence: 99%

Machine Perfusion Preservation Improves Renal Allograft Survival

Kwiatkowski

Wszoła

Kosieradzki

et al. 2007

American Journal of Transplantation

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Machine perfusion (MP) has been used as the kidney preservation method in our center for over 10 years. The first, small (n = 74) prospective, single-blinded randomized study comparing MP and Cold Storage (CS) showed that the incidence of delayed graft function was higher after CS. There have been no reports in the literature on the effect of storage modality on longterm function of renal allografts. This paper presents an analysis of long-term results of renal transplantation in 415 patients operated on between 1994 and 1999. Of those, 227 kidneys were MP-stored prior to KTx. The control group consisted of 188 CS kidney transplants. Kidneys were not randomized to MP or to CS. Donor demographics, medical and biochemical data, cold ischemia time, HLA match and recipient data were collected. Standard triple-drug immunosuppression was administered to both groups. Mortality, graft survival and incidence of return to hemodialysis treatment were analyzed. Despite longer cold ischemia time and poorer donor hemodynamics in MP group, 5-year Kaplan-Meier graft survival was better in MP-stored than in CS-stored kidneys (68.2% vs. 54.2%, p = 0.02). Conclusion: In this nonrandomized analysis, kidney storage by MP improved graft survival and reduced the number of patients who returned to dialysis.

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Section: Discussionmentioning

confidence: 99%

Machine Perfusion Preservation Improves Renal Allograft Survival

Kwiatkowski

Wszoła

Kosieradzki

et al. 2007

American Journal of Transplantation

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“…37,40,51 Five studies explicitly stated that the kidneys came from HBDs, 13,34,35,48,49 and the remainder did not specify whether the donors were heart beating or not. It is likely that in all such cases they were HBDs, with the possible exception Information on the length of preservation time is available in 11 studies.…”

Section: Quality Of Included Studiesmentioning

confidence: 99%

“…It is likely that in all such cases they were HBDs, with the possible exception Information on the length of preservation time is available in 11 studies. 13,14,[33][34][35]37,38,40,46,[49][50][51] In these, the mean preservation time for CS kidneys varied from 6 37 to 33 h, 35 and for MP from 12 37 to 35 h. 35 (It should be noted that MP did not necessarily last for the whole time that kidneys were ischaemic -in many cases it was only used for part of the time, and kidneys were simply kept in CS for the rest of the time.) In nine of the 11 studies the ischaemic time was longer in MP than in CS kidneys, with the difference varying between -4 h (i.e.…”

Section: Quality Of Included Studiesmentioning

confidence: 99%

“…Most commonly, this is reported as the requirement for dialysis in the first week postoperatively, 13,33,35,37,38,40,49,50 although in other cases it is reported as dialysis requirement in the first 2 weeks, 46 as urine output 48 or decline in creatinine over 4 days postoperatively. 34 In some papers the presence of acute tubular necrosis (ATN) or DGF was reported as an outcome, although the diagnostic criteria for this were not specified.…”

Section: Immediate Graft Functionmentioning

confidence: 99%

“…37 The three studies with NHBDs and the oldest study all reported high rates of DGF. The incidence of DGF in the MP kidneys varied from 12 49 to 80%. 44 The relative risk of DGF in kidneys preserved by MP as compared with CS within individual studies varied from 0.5 49 to 2.5.…”

Section: Immediate Graft Functionmentioning

confidence: 99%

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The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors

Wight

Chilcott²,

Holmes³

et al. 2003

Health Technol Assess

125

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Issues and Surgical Techniques to Expand the Pool of Kidneys Available for Transplantation

Modlin¹

2010

Kidney and Pancreas Transplantation

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Comparison of static versus pulsatile preservation of matched-paired kidneys

Cited by 15 publications

References 3 publications

Machine Perfusion Preservation Improves Renal Allograft Survival

Machine Perfusion Preservation Improves Renal Allograft Survival

The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors

Issues and Surgical Techniques to Expand the Pool of Kidneys Available for Transplantation

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