2023
DOI: 10.1002/jrsm.1648
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Comparison of statistical methods for integrating real‐world evidence in a rare events meta‐analysis of randomized controlled trials

Abstract: Rare events meta‐analyses of randomized controlled trials (RCTs) are often underpowered because the outcomes are infrequent. Real‐world evidence (RWE) from non‐randomized studies may provide valuable complementary evidence about the effects of rare events, and there is growing interest in including such evidence in the decision‐making process. Several methods for combining RCTs and RWE studies have been proposed, but the comparative performance of these methods is not well understood. We describe a simulation … Show more

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Cited by 5 publications
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