Comparison of systemic and localized carrier-mediated delivery of methylprednisolone succinate for treatment of acute spinal cord injury

Baltin, Maxim; Sabirova, Diana E; Kiseleva, Elvira I; Kamalov, Marat I.; Abdullin, Timur I.; Petrova, N. V.; Ahmetov, Nafis; Sachenkov, Oskar; Baltina, Tatyana; Lavrov, Igor

doi:10.1007/s00221-020-05974-w

Cited by 13 publications

(14 citation statements)

References 56 publications

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“…However, the use of MP for the treatment of TSCI has been very effective. MP has been shown to inhibit early inflammatory processes and lipid peroxidation, reduce edema and cell apoptosis, maintain neuronal excitability, and improve microcirculation after TSCI (Rabchevsky et al, 2002;Baltin et al, 2021). The results on the use of MP in animal models have been promising; however, human clinical trials have produced mixed results.…”

Section: Discussionmentioning

confidence: 99%

Methylprednisolone Induces Neuro-Protective Effects via the Inhibition of A1 Astrocyte Activation in Traumatic Spinal Cord Injury Mouse Models

et al. 2021

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Traumatic spinal cord injury (TSCI) leads to pathological changes such as inflammation, edema, and neuronal apoptosis. Methylprednisolone (MP) is a glucocorticoid that has a variety of beneficial effects, including decreasing inflammation and ischemic reaction, as well as inhibiting lipid peroxidation. However, the efficacy and mechanism of MP in TSCI therapy is yet to be deciphered. In the present study, MP significantly attenuated the apoptotic effects of H2O2 in neuronal cells. Western blot analysis demonstrated that the levels of apoptotic related proteins, Bax and cleaved caspase-3, were reduced while levels of anti-apoptotic Bcl-2 were increased. In vivo TUNEL assays further demonstrated that MP effectively protected neuronal cells from apoptosis after TSCI, and was consistent with in vitro studies. Furthermore, we demonstrated that MP could decrease expression levels of IBA1, Il-1α, TNFα, and C3 and suppress A1 neurotoxic reactive astrocyte activation in TSCI mouse models. Neurological function was evaluated using the Basso Mouse Scale (BMS) and Footprint Test. Results demonstrated that the neurological function of MP-treated injured mice was significantly increased. In conclusion, our study demonstrated that MP could attenuate astrocyte cell death, decrease microglia activation, suppress A1 astrocytes activation, and promote functional recovery after acute TSCI in mouse models.

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Section: Discussionmentioning

confidence: 99%

Methylprednisolone Induces Neuro-Protective Effects via the Inhibition of A1 Astrocyte Activation in Traumatic Spinal Cord Injury Mouse Models

et al. 2021

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“…Although systemic steroids are gaining increased popularity in Enhanced Recovery After Surgery (ERAS), the benefits of local steroid infiltration have been well known since as early as 1999 when Dammers et al used 40 mg methylprednisolone with 10 mg Lignocaine for Carpal Tunnel Syndrome and achieved tremendous results [ 35 ]. Systemic steroid use reduces the postoperative risk of PONV and acute pain [ 36 ]; however, a significant rise in blood glucose is also a known side effect of steroid use [ 37 ], along with sepsis, pneumonia, GI bleed, wound infection, and acute corticosteroid myopathy [ 38 ]. A multimodal analgesic regimen is widely used to improve outcomes, and the use of systemic and local corticosteroids as adjuncts has been suggested by previous studies [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Methylprednisolone as an Adjunct to Local Infiltration on Laminoplasty or Laminectomy before Wound Closure: A Randomized Controlled Trial

Shrestha

Han

Wang

et al. 2022

Pain Research and Management

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TrialDesign. Patients undergoing laminoplasty and laminectomy often experience severe postoperative pain. Local infiltration analgesia during spine surgery significantly reduces postoperative pain, which only upholds for a short time. Whether methylprednisolone and local anaesthetics are better than local anaesthetics alone in postoperative analgesia is yet to be determined. The primary aim of this research was the postoperative evaluation of efficacy and safety of methylprednisolone when used as an adjunct to local anaesthesia, ropivacaine, before wound closure after surgical procedures, laminoplasty or laminectomy. Methods. 132 patients were divided with a ratio of 1 : 1 into methylprednisolone-ropivacaine and ropivacaine alone groups. Every 30 ml of local infiltration solution consisted of 15 ml of 1% ropivacaine with 14 ml of saline along with 1 ml of 40 mg methylprednisolone and 15 ml of 1% ropivacaine with 15 ml of saline in methylprednisolone-ropivacaine group and ropivacaine group, respectively. The standardization of the study solution depended on the number of levels involved in surgery. Primary outcome was the 48-hour cumulative sufentanil demand. Results. Demographic characters and surgical variables among the groups were identical. The average 48-hour cumulative sufentanil demand was 32.5 ± 20.6 μg in the methylprednisolone-ropivacaine group and 50.9 ± 27.2 μg in the ropivacaine group ( p < 0.001 ). The estimated median time of demand of the first analgesia via patient-controlled analgesia (PCA) pump was 2.5 hours and 2 hours in the methylprednisolone-ropivacaine group and the ropivacaine group, respectively (hazard ratio (HR) was 0.53, with 95% Cl 0.33 to 0.87 and Log-rank of p = 0.0019 ). Conclusion. The infiltration of methylprednisolone as adjunct ropivacaine before wound closure is a safe and efficient strategy for pain management following laminoplasty or laminectomy.

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“…Next, the angles in the hip, knee, and ankle joint at each moment of time can be calculated according to the equations [ 6 ]:

…”

Section: Methodsmentioning

confidence: 99%

“…M. Baltin et al [ 6 ] studied changes in the range of motion of the hind limbs of rats induced by epidural stimulation in the acute phase of SCI and recovery of movements was assessed. A kinematic analysis of complete stepping cycles was performed for animals of each group.…”

Section: Introductionmentioning

confidence: 99%

The Automatization of the Gait Analysis by the Vicon Video System: A Pilot Study

Smirnova

Khamatnurova

Kharin

et al. 2022

Sensors

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The quality of modern measuring instruments has a strong influence on the speed of diagnosing diseases of the human musculoskeletal system. The research is focused on automatization of the method of gait analysis. The study involved six healthy subjects. The subjects walk straight. Each subject made several gait types: casual walking and imitation of a non-standard gait, including shuffling, lameness, clubfoot, walking from the heel, rolling from heel to toe, walking with hands in pockets, and catwalk. Each type of gait was recorded three times. For video fixation, the Vicon Nexus system was used. A total of 27 reflective markers were placed on the special anatomical regions. The goniometry methods were used. The walk data were divided by steps and by step phases. Kinematic parameters for estimation were formulated and calculated. An approach for data clusterization is presented. For this purpose, angle data were interpolated and the interpolation coefficients were used for clustering the data. The data were processed and four cluster groups were found. Typical angulograms for cluster groups were presented. For each group, average angles were calculated. A statistically significant difference was found between received cluster groups.

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Comparison of systemic and localized carrier-mediated delivery of methylprednisolone succinate for treatment of acute spinal cord injury

Cited by 13 publications

References 56 publications

Methylprednisolone Induces Neuro-Protective Effects via the Inhibition of A1 Astrocyte Activation in Traumatic Spinal Cord Injury Mouse Models

Methylprednisolone Induces Neuro-Protective Effects via the Inhibition of A1 Astrocyte Activation in Traumatic Spinal Cord Injury Mouse Models

Methylprednisolone as an Adjunct to Local Infiltration on Laminoplasty or Laminectomy before Wound Closure: A Randomized Controlled Trial

The Automatization of the Gait Analysis by the Vicon Video System: A Pilot Study

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