Comparison of the computed tomography findings in COVID-19 and other viral pneumonia in immunocompetent adults: a systematic review and meta-analysis

Altmayer, Stephan; Zanon, Matheus; Pacini, Gabriel Sartori; Watte, Guilherme; Barros, Marcelo Cardoso; Mohammed, Tan-Lucien; Verma, Nupur; Marchiori, Edson; Hochhegger, Bruno

doi:10.1007/s00330-020-07018-x

Cited by 63 publications

(72 citation statements)

References 55 publications

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“…Non-COVID viral pneumonias share many CT features with COVID-19, except for a higher prevalence of pleural effusions. In a systematic review of 33 studies, comprising 1911 patients equally distributed between COVID-19 and non-COVID viral pneumonias (mainly influenza A and adenovirus), pleural effusions were observed in 3% and 25% of the cases, respectively [ 21 ]. Regarding other beta-coronaviruses, very few small series on CT appearances have been reported and, therefore, firm conclusions cannot be drawn.…”

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confidence: 99%

Pleural diseases and COVID-19:ubi fumus, ibi ignis

Porcel

2020

Eur Respir J

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More than 45 000 articles in the PubMed database and around 3200 studies registered in ClinicalTrials.gov, of which greater than half are clinical trials, is the result of ongoing and relentless research into the global pandemic nature of an acute respiratory disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which made its initial appearance in December 2019 in China. As of August 28, the total confirmed cases of coronavirus disease 2019 (COVID-19) surpass 24.5 million people, with over 830 000 global deaths [1]. An estimated 40% to 45% of persons infected with SARS-CoV-2 will remain asymptomatic, but they can transmit the virus to others for an extended period, perhaps longer than 14 days [2]. The primary presentation of symptomatic infection is that of an influenza-like illness or viral pneumonia, with about 20% of these patients developing severe or critical manifestations [3].

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confidence: 99%

Pleural diseases and COVID-19:ubi fumus, ibi ignis

Porcel

2020

Eur Respir J

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“…[ 41 42 ] SARS, H1N1 and Covid-19 have similar specific appearances of multi focal areas of ground glass density in a subpleural location with lower lobe preponderance. [ 14 32 43 44 45 46 47 48 49 50 51 ] Differentiation between these is difficult as the appearances overlap.…”

Section: Discussionmentioning

confidence: 99%

Does CT help in reducing RT-PCR false negative rate for COVID-19?

Kohli

Joshi

Shah³

et al. 2021

Indian Journal of Radiology and Imaging

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Background: Early detection is the key to contain the ongoing pandemic. The current gold standard to detect SARS CoV2 is RT-PCR. However, it has a high false negative rate and long turnaround time. Purpose: In view of the high sensitivity of CT in detection of lower respiratory tract pathologies, a study of 2581 patients comparing RT-PCR status with CT findings was undertaken to see if it augments the diagnostic performance. Materials and Methods: A multi centre prospective study of consecutive cases was conducted. All CT studies suggestive of COVID 19 pneumonia were collated and evaluated independently by three Radiologists to confirm the imaging diagnosis of COVID-19 pneumonia. The RT-PCR values were retrospectively obtained, based on the RT-PCR values, CT studies were categorised into three subgroups, positive, negative and unknown. CT features from all three groups were compared to evaluate any communality or discordance. Results: Out of the 2581 patients with positive CT findings for COVID pneumonia, 825 were females and 1,756 were males in a wide age group of 28-90 years. Predominant CT features observed in all the subgroups were Ground glass densities 94.8%, in mixed distribution (peripheral and central) (59.12%), posterior segments in 92% and multilobar involvement in 70.9%. The CT features across the three subgroups were statistically significant with a P value <0.001. Conclusion: There was a communality of CT findings regardless of RT-PCR status. In a pandemic setting ground glass densities in a subpleural, posterior and basal distribution are indicative of COVID 19. Thus CT chest in conjunction to RT PCR augments the diagnosis of COVID 19 pneumonia; utilization of CT chest may just be the missing link in closing this pandemic.

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“…According to a recent meta-analysis, Altmayer et al found that both COVID-19 associated and other types of viral pneumonia had overlapping CT findings, except for a higher prevalence of peripheral distribution and involvement of the upper and middle lobes. 42 Both SARS and MERS share common findings with COVID-19 due to their similar pathogenesis. 47,48 However, CT changes related to SARS and MERS are commonly unifocal, as opposed to the multifocal changes usually seen in COVID-19.…”

Section: H E S T R a D I O G R A P H F I N D I N G Smentioning

confidence: 96%

COVID-19 Associated Pneumonia

Umairi

Al-Kalbani

Al-Tai

et al. 2021

Sultan Qaboos Univ Med J

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Medical imaging, including chest radiography and computed tomography, plays a major role in the diagnosis and follow-up of patients with COVID-19 associated pneumonia. This review aims to summarise current information on this topic based on the existing literature. A search of the Google Scholar (Google LLC, Mountain View, California, USA) and MEDLINE® (National Library of Medicine, Bethesda, Maryland, USA) databases was conducted for articles published until April 2020. A total of 30 articles involving 4,002 patients were identified. The most frequently reported imaging findings were bilateral ground glass and consolidative pulmonary opacities with a predominant lower lobe and peripheral subpleural distribution. KEYWORDS COVID-19; Viral Pneumonia; Diagnostic Imaging; X-Ray Computed Tomography; Radiography;Review.

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Comparison of the computed tomography findings in COVID-19 and other viral pneumonia in immunocompetent adults: a systematic review and meta-analysis

Cited by 63 publications

References 55 publications

Pleural diseases and COVID-19:ubi fumus, ibi ignis

Pleural diseases and COVID-19:ubi fumus, ibi ignis

Does CT help in reducing RT-PCR false negative rate for COVID-19?

COVID-19 Associated Pneumonia

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