Comparison of the effects and mechanism of the curcumin with different acting drugs in experimental vasospasm after subarachnoid hemorrhage

Aydın, Hasan Emre; Bektur, Nuriye Ezgi; Özbek, Zühtü; Öner, Setenay; Bayçu, Cengiz; Kılıç, Fatma Sultan

doi:10.5137/1019-5149.jtn.17432-16.2

Cited by 2 publications

(1 citation statement)

References 24 publications

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“…Similar improvements in the rate of vasospasm were seen in a recent study comparing the actions of nimodipine, nicorandil, and low and high-dose curcumin on cerebral vasospasm. This demonstrated that high-dose curcumin is associated with a lower rate of vasospasm compared to nimodipine and nicorandil [166]. Unfortunately, this study did not perform any behavioural testing.…”

Section: Sulforaphanementioning

confidence: 99%

Neuroprotective Role of the Nrf2 Pathway in Subarachnoid Haemorrhage and Its Therapeutic Potential

Zolnourian

Galea

Bulters

2019

Oxidative Medicine and Cellular Longevity

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The mechanisms underlying poor outcome following subarachnoid haemorrhage (SAH) are complex and multifactorial. They include early brain injury, spreading depolarisation, inflammation, oxidative stress, macroscopic cerebral vasospasm, and microcirculatory disturbances. Nrf2 is a global promoter of the antioxidant and anti-inflammatory response and has potential protective effects against all of these mechanisms. It has been shown to be upregulated after SAH, and Nrf2 knockout animals have poorer functional and behavioural outcomes after SAH. There are many agents known to activate the Nrf2 pathway. Of these, the actions of sulforaphane, curcumin, astaxanthin, lycopene, tert-butylhydroquinone, dimethyl fumarate, melatonin, and erythropoietin have been studied in SAH models. This review details the different mechanisms of injury after SAH including the contribution of haemoglobin (Hb) and its breakdown products. It then summarises the evidence that the Nrf2 pathway is active and protective after SAH and finally examines the evidence supporting Nrf2 upregulation as a therapy after SAH.

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Section: Sulforaphanementioning

confidence: 99%

Neuroprotective Role of the Nrf2 Pathway in Subarachnoid Haemorrhage and Its Therapeutic Potential

Zolnourian

Galea

Bulters

2019

Oxidative Medicine and Cellular Longevity

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A Systematic Review of Inflammatory Cytokine Changes Following Aneurysmal Subarachnoid Hemorrhage in Animal Models and Humans

Devlin

Ishrat

Stanfill

2022

Transl. Stroke Res.

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Comparison of the effects and mechanism of the curcumin with different acting drugs in experimental vasospasm after subarachnoid hemorrhage

Abstract: ABSTRACTexperimental and clinical studies, the exact underlying mechanisms for the associated pathological conditions such as vasospasm remain to be identified. Major histological change during the cerebral vasospasm after SAH is the endothelial cell injury induced by apoptosis.

Cited by 2 publications

References 24 publications

Neuroprotective Role of the Nrf2 Pathway in Subarachnoid Haemorrhage and Its Therapeutic Potential

Neuroprotective Role of the Nrf2 Pathway in Subarachnoid Haemorrhage and Its Therapeutic Potential

A Systematic Review of Inflammatory Cytokine Changes Following Aneurysmal Subarachnoid Hemorrhage in Animal Models and Humans

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