Comparison of the effects of intra-arterial and locally applied vasoactive agents on pulpal blood flow in dog canine teeth determined by laser doppler velocimetry

Liu, M.; Kim, Sungpyo; Park, D.S.; Markowitz, Kenneth; Bilotto, G.; Dörscher-Kim, J.

doi:10.1016/0003-9969(90)90188-g

Cited by 39 publications

(18 citation statements)

References 15 publications

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“…In dog oral tissues, Kim and colleagues (1986) and Liu and colleagues (1990) found a decrease in pulpal blood flow after intra-arterial injection of 5-HT. Furthermore, local application of 5-HT in tooth cavities in dogs causes a decrease in pulpal blood flow (Liu et al, 1990). This decrease in pulpal blood flow was suggested to be due to either arteriolar vasoconstriction or vasodilation produced by passive venular compression in a low compliance environment, such as the pulp, thereby indirectly reducing the pulpal blood flow (Kim et al, 1986;Liu et al, 1990).…”

Section: Discussionmentioning

confidence: 98%

“…Furthermore, local application of 5-HT in tooth cavities in dogs causes a decrease in pulpal blood flow (Liu et al, 1990). This decrease in pulpal blood flow was suggested to be due to either arteriolar vasoconstriction or vasodilation produced by passive venular compression in a low compliance environment, such as the pulp, thereby indirectly reducing the pulpal blood flow (Kim et al, 1986;Liu et al, 1990). Ngassapa and colleagues (1992) reported both an initial increase (in two trials) and decrease (in five trials) in pulpal blood flow after local application of 5-HT in cavities of dog canine teeth.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, 5-HT has been shown to excite intradental nerves in cats (Olgart, 1974) and to sensitize intradental nerves to various hydrodynamic stimuli in beagle dogs (Ngassapa et al, 1992). Local application of 5-HT in deep cavities of dog teeth has been shown to induce vasoconstriction (Liu et al, 1990). Furthermore, 5-HT has been found to stimulate the release of prostacyclin and prostaglandin E 2 in rat dental pulp (Hirafuji & Ogura, 1987).…”

Section: Introductionmentioning

confidence: 98%

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5-Hydroxytryptamine immunoreactivity is detectable in sympathetic nerve fibres in rat oral tissues

1996

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The aim of this investigation was to examine if 5-hydroxytryptamine (5-HT) is detectable not only in mast cells but also in sympathetic nerve fibres in oral sites of the rat, including the periodontal ligament, pulp, palatal mucosa, and vestibular sulcus. Antibodies against 5-HT and tyrosine hydroxylase were used. Maxillae from rats were dissected free, fixed, decalcified, cut transversally, and processed for immunohistochemistry. Nerve fibres showing 5-HT-like immunoreactivity were regularly observed in the walls of the arteries and arterioles in the vestibular sulcus and the periodontal ligament. However, 5-HT-like immunoreactivity was not seen in the walls of the vessels of the palatal mucosa. Interestingly, 5-HT-like immunoreactivity coexisted with tyrosine hydroxylase-like immunoreactivity in the innervation of the periodontal ligament and the vestibular sulcus. Thus, the present study gives morphological correlate for the occurrence of effects of 5-HT derived not only from mast cells but also from sympathetic nerve fibres in oral tissues. The source of 5-HT in the nerve fibres as well as the functional implications of the observations remain to be determined.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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5-Hydroxytryptamine immunoreactivity is detectable in sympathetic nerve fibres in rat oral tissues

1996

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“…Avery and Chiego, 1990). When applied locally on dog pulps, Ach triggers a rise in pulpal blood flow (Okabe et al, 1989;Liu et al, 1990). Ach receptors have also been encountered in porcine dental pulp (Sano et al, 1989).…”

Section: Parasympathetic Systemmentioning

confidence: 99%

“…Although local application of p-adrenoceptor agonists on the pulp causes vasodilation, thereby implying the presence of these receptors in the pulp (Okabe et al, 1989;Liu et al, 1990), there is little evidence that they have any significance in neural control. The only functional evidence for a sympathetic nerve-induced vasodilation mediated by P-adrenoceptors in the pulp was obtained by direct tooth stimulation of the incisor in the rat (Kerezoudis et al, 1992).…”

Section: Sympathetic Systemmentioning

confidence: 99%

Neural Control of Pulpal Blood Flow

Olgart

1996

Critical Reviews in Oral Biology & Medicine

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Blood flow of mammalian dental pulp is under both remote and local control. There is evidence for the existence of parasympathetic nerves in the pulp, but functionally the cholinergic influence is weak, and the physiological significance of this autonomic system seems to be low. The evidence for sympathetic vasoconstrictor nerves in the pulp is robust, and there is convincing support for the contention that these nerves play a physiological role, operating via release of noradrenaline and neuropeptide Y. However, there is no significant functional evidence in support of sympathetic beta-adrenoceptor-mediated vasodilation in the pulp. The local control of blood flow involves a subset of intradental sensory nerves. By virtue of their neuropeptide content, these afferent fibers cause vasodilation and inhibit sympathetic vasoconstriction in response to painful stimulation of the tooth. Such locally governed control may serve to meet immediate demands of the pulp tissue. A locally triggered reflex activation of sympathetic nerves in the pulp may modulate this control and limit its magnitude. Thus, there are competitive interactions between local and remote vascular controls which may be put out of balance in the injured and inflamed dental pulp.

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In situ testing of CO₂ laser on dental pulp function: Effects on microcirculation

et al. 1991

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The effect of CO2 laser irradiation on pulpal microcirculation was studied in cat canines. The enamel surfaces of 4 teeth were exposed with energy densities of 304-1440J/cm2, using either a handpiece or a microslad, with a focal spot of 0.21mm and 0.33mm respectively. Pulpal blood flow (PBF) before and following lasing was recorded through the intact tooth surface by a laser Doppler flowmeter. CO2 laser irradiation caused an increase in PBF, which was immediate and transient. The PBF increase was higher in a large pulp than in a small pulp, and it was inversely related to the focal spot size. These findings confirm that the dental pulp is thermally affected by CO2 lasing of the tooth surface, however, without extensive pulp coagulation. It is concluded that the effects of laser irradiation on the pulpal microcirculation may be studied in situ by means of the presented methodology.

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Comparison of the effects of intra-arterial and locally applied vasoactive agents on pulpal blood flow in dog canine teeth determined by laser doppler velocimetry

Cited by 39 publications

References 15 publications

5-Hydroxytryptamine immunoreactivity is detectable in sympathetic nerve fibres in rat oral tissues

5-Hydroxytryptamine immunoreactivity is detectable in sympathetic nerve fibres in rat oral tissues

Neural Control of Pulpal Blood Flow

In situ testing of CO₂ laser on dental pulp function: Effects on microcirculation

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Comparison of the effects of intra-arterial and locally applied vasoactive agents on pulpal blood flow in dog canine teeth determined by laser doppler velocimetry

Cited by 39 publications

References 15 publications

5-Hydroxytryptamine immunoreactivity is detectable in sympathetic nerve fibres in rat oral tissues

5-Hydroxytryptamine immunoreactivity is detectable in sympathetic nerve fibres in rat oral tissues

Neural Control of Pulpal Blood Flow

In situ testing of CO2 laser on dental pulp function: Effects on microcirculation

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Product

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In situ testing of CO₂ laser on dental pulp function: Effects on microcirculation