Comparison of the efficacy and safety of two eye gels in the treatment of dry eyes: Lacrinorm and Viscotears

Bron, A. J.; Daubas, Philippe; Siou-Mermet, Raphaële; Trinquand, C.

doi:10.1038/eye.1998.215

Cited by 29 publications

(23 citation statements)

References 7 publications

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“…Repeated use of eye drops with preservatives, especially BAK-containing products (e.g. GelTears), is associated with ocular allergies and toxicities (Baudouin 2010; Bron 1998a). These complications can lead to discontinuation of the products and worsening of the condition.…”

Section: Introductionmentioning

confidence: 99%

Over the counter (OTC) artificial tear drops for dry eye syndrome

Pucker

Nichols

2016

Cochrane Database of Systematic Reviews

128

124

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Background-Over the counter (OTC) artificial tears historically have been the first line of treatment for dry eye syndrome and dry eye-related conditions like contact lens discomfort, yet currently we know little regarding the overall efficacy of individual, commercially available artificial tears. This review provides a much needed meta-analytical look at all randomized and quasi-randomized clinical trials that have analyzed head-to-head comparisons of OTC artificial tears. Objectives-To evaluate the effectiveness and toxicity of OTC artificial tear applications in the treatment of dry eye syndrome compared with another class of OTC artificial tears, no treatment, or placebo. Search methods-We searched CENTRAL (which contains the Cochrane Eyes and Vision Trials Register) (2015, Issue 12), Ovid MEDLINE, Ovid MEDLINE In-Process and Other Non-Indexed Citations, Ovid MEDLINE Daily, Ovid OLDMEDLINE (January 1946 to December 2015), EMBASE (January 1980 to December 2015), Latin American and Caribbean Health Sciences (LILACS) (January 1982 to December 2015), the ISRCTN registry (www.isrctn.com/ editAdvancedSearch), ClinicalTrials.gov (www.clinicaltrials.gov), the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en)

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Section: Introductionmentioning

confidence: 99%

Over the counter (OTC) artificial tear drops for dry eye syndrome

Pucker

Nichols

2016

Cochrane Database of Systematic Reviews

128

124

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“…EDED gained relevance based on the recognition that environmental factors can be deleterious to human health and contributes to DED (11,12) . The impact of the environment in the pathophysiology…”

Section: Introductionmentioning

confidence: 99%

Is dry eye an environmental disease?

Alves¹,

Novaes²,

Morraye³

et al. 2014

Arquivos Brasileiros De Oftalmologia

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Previous studies have revealed that eye contact with either air pollutants or adverse indoor and/or outdoor environmental conditions can affect tear film composition and ocular surface components. These effects are mediated by selective binding of the environmental agents to ocular surface membrane receptors, leading to activation of pro inflammatory signaling pathways. The aim of the current review was to examine the published evidence associated with environmental factors and ocular surface disease and dry eye. Specifically, the reader will appreciate why it is possible to refer to them as mediators of Environmental Dry Eye Disease (EDED), a singular clinical entity inside DED context, directly caused by pollutants and/ or adverse climatic conditions. The indicators and clinical findings are described along with EDE differential diagnosis in its acute and the chronic phases. Based on strong existing evidence of clinical reports and epidemiological observations regarding DED and environmental factors we conclude that there is a straight cause-and-effect relationship between ambient stresses and DED. International standards and web-based tools are described for monitoring worldwide environmental conditions referring localities and populations susceptible to EDED. This information is beneficial to health providers to pinpoint the individuals and predisposed groups afflicted with DED. Such insights may not only improve the understanding and treatment of DED but also help to identify the contributing factors and lower the frequency and progression of EDED. of DED has been studied and confirmed in animal models of human DED (13)(14)(15) . KeywordsAs indicated, a healthy and pain-free ocular surface depends on identifying and eliminating factors that cause ambient humidity, airflow and purity, and temperature to intolerable levels. Such an undertaking is needed to preserve tear film qualities commensurate with ocular surface health. This is essential to sustain sufficient corneal refractive power, visual acuity, and ocular comfort (5,16,17) . A desiccating environment can lead to increase in tear film evaporation and/or decline in its turn over and clearance. These initial events lead to exposure of the ocular surface to hazardous environmental elements that trigger or exacerbate EDED symptoms. Clinical findings have shown that increased numbers of people are affected by EDED because of exposure to environmental factors ( Figure 2).Our purpose herein is to provide a critical appraisal of the clinical and epidemiological evidence indicating that DED is influenced by environmental factors. Secondly, we delineate EDED as a single clinical entity with a unique set of symptoms and clinical findings different from that of either DED or other diseases, such as Sjögren's syndrome, diabetes mellitus or drug induced, allergic conjunctivitis, toxic or irritative conjunctivitis, and actinic keratitis. Moreover, we will describe standard tools used to monitor environmental conditions and discuss their relevance in EDED ep...

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“…Further positive characteristics of VS are a good distribution on the conjunctiva and cornea as well as a clear consistency and cooling effect [8,9,12].…”

Section: Discussionmentioning

confidence: 97%

Patient satisfaction and postoperative pain with different postoperative therapy regimens after standardized cataract surgery: a randomized intraindividual comparison

2011

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The purpose of this study was to evaluate if administration of artificial tears of high or low-viscosity improve cataract patients' satisfaction and postoperative pain after cataract surgery. Thirty consecutive patients undergoing bilateral cataract surgery under topical anesthesia were enrolled prospectively. Administration of the following postoperative therapies was randomized: for all participants, one eye was treated with "instant vision" (IV) therapy alone (IV-alone), i.e., this eye remained uncovered. In group 1 (n = 11), the second eye received IV therapy with Hylo-Comod(®) (HC) eye drops; in group 2 (n = 9), IV with Vidisic(®) (VS) eye drops; in group 3 (n = 10), an ointment bandage (OB). Postoperative satisfaction, pain scores, visual acuity, intraocular pressure, tear break-up time and postoperative corneal changes were compared. Group 1: No clear preference was observed for any of the methods concerning subjective satisfaction. Group 2: 100% of patients preferred IV + VS therapy. Group 3: Patients' postoperative satisfaction with OB therapy was 89%. Concerning postoperative pain perception, no significant differences were found between IV therapy alone and the IV-combination therapies. Significant differences in pain perception (P < 0.042) were measured between IV and OB in the first 8 h postoperatively. Ten hours postoperatively and beyond, there were no significant differences in pain scores (P > 0.05). Pain perception was significantly lower with OB when compared to IV-alone or IV-combination therapies using artificial tears. This result was verified by OB's 89% patient satisfaction level. Low-viscosity artificial tears showed no significant subjective benefits for the patients; patient satisfaction was greatest (100%) with a high-viscosity tear substitute.

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Comparison of the efficacy and safety of two eye gels in the treatment of dry eyes: Lacrinorm and Viscotears

Cited by 29 publications

References 7 publications

Over the counter (OTC) artificial tear drops for dry eye syndrome

Over the counter (OTC) artificial tear drops for dry eye syndrome

Is dry eye an environmental disease?

Patient satisfaction and postoperative pain with different postoperative therapy regimens after standardized cataract surgery: a randomized intraindividual comparison

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