Comparison of the efficacy of Poly(I:C) immunization with live vaccine and formalin-killed vaccine against viral hemorrhagic septicemia virus (VHSV) in olive flounder (Paralichthys olivaceus)

Kim, Hyoung Jun; Park, Jeong Su; Choi, Min Chul; Kwon, Se Ryun

doi:10.1016/j.fsi.2015.11.035

Cited by 22 publications

(15 citation statements)

References 26 publications

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“…Even in the systemic compartment, our knowledge on the role of B cells and Igs upon viral challenge is still very fragmented. It is well-documented that protection of fish against viruses is not always correlated with the levels of specific antibodies detected in the serum of infected hosts (Kim et al, 2016). However, the importance of mucosal antibodies in viral defense has been tested in very few studies so far.…”

Section: Mucosal B Cell Responses In Gutmentioning

confidence: 99%

B cells and their role in the teleost gut

Parra

Korytář

Takizawa

et al. 2016

Developmental & Comparative Immunology

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Mucosal surfaces are the main route of entry for pathogens in all living organisms. In the case of teleost fish, mucosal surfaces cover the vast majority of the animal. As these surfaces are in constant contact with the environment, fish are perpetually exposed to a vast number of pathogens. Despite the potential prevalence and variety of pathogens, mucosal surfaces are primarily populated by commensal non-pathogenic bacteria. Indeed, a fine balance between these two populations of microorganisms is crucial for animal survival. This equilibrium, controlled by the mucosal immune system, maintains homeostasis at mucosal tissues. Teleost fish possess a diffuse mucosa-associated immune system in the intestine, with B cells being one of the main responders. Immunoglobulins produced by these lymphocytes are a critical line of defense against pathogens and also prevent the entrance of commensal bacteria into the epithelium. In this review we will summarize recent literature regarding the role of B-lymphocytes and immunoglobulins in gut immunity in teleost fish, with specific focus on immunoglobulin isotypes and the microorganisms, pathogenic and non-pathogenic that interact with the immune system.

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Section: Mucosal B Cell Responses In Gutmentioning

confidence: 99%

B cells and their role in the teleost gut

Parra

Korytář

Takizawa

et al. 2016

Developmental & Comparative Immunology

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“…Pathway Genes SVCV TLR/RLR signaling TLR2, TLR5 [38~40] , TLR3 [38~41] , TLR22 [42,43] , RIG-I, RIG-Ia, RIG-Ib [44,45] , TBK1, MAVS [46,47] , NLRC5 [48] , NOD2, RIPK2 [47,49,50] IFN signaling IFNΦ1, IFNΦ2, IFNΦ3, IFNΦ4 [41,46,51,52] , IFNγ1, IFNγ2 [41,53,54] , ISG [41,55] , MxA, MxB [41,51] MAPK signaling Mapk, map2k1, map3k, map3k7 [19,56] , mapk14 [56] Complement c2, cr2, cd59, hbl4, masp2, kng1 [57~59] Other IRF3, IRF4, IRF4a, IRF4b, IRF7 [51,60,61] , C-Rel [60] , TNFα, Rac1, STAT6 [41~43,54] , IL-1β, IL-10, IL-12 [41,62,54] , AKT3a, nfkb2, TGF-β [19,56] , md1, rp105 [63] , ProTαβ, ProTβ-1 [64] , cd4, cd8 [65] , mhc2dab [48] , pk3r5, faslg, casp3b [19,56] , IgZ, IgD, IgM [19,66,67] , RAG1, BCR, TCR [65] VHSV TLR/RLR signaling TLR3, TLR8a1, TLR8b1, TLR22…”

Section: 目前在弹状病毒感染时关于斑马鱼Nod样受mentioning

confidence: 99%

“…也有报道构建VHSV病毒G蛋白基因质粒(pAE6-GVHSV) DNA疫苗注射斑马鱼, 结果表明VHSV病毒G蛋白基因疫苗有助于抗弹状病毒免疫应答机制 [135] . VHSV病毒重组rgpG疫苗能有效保护斑马鱼抵抗VHSV病毒感染, 并且明显诱导斑马鱼早期免疫应答 [67,81] . VHSV病毒G蛋白作为DNA疫苗参与启动Ⅰ型IFN抗病毒应答, 而且与弹状病毒主要决定簇多肽p31, p33抗原有关, 有助于理解VHSV病毒感染诱导斑马鱼Ⅰ型IFN系统非特异性免疫应答机制 [82] .…”

Section: 马鱼免疫应答转录组谱分析结果发现3天后有50多个unclassified

Zebrafish as a model for Rhabdovirus infection and molecular mechanism of the immune response

Song¹,

Hu²,

Lü³

et al. 2018

Sci. Sin.-Vitae

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“…Vaccination is a pivotal strategy in protecting against fish infectious diseases and subsequently reducing the economic losses in aquaculture. Over the years, there have been several research studies worldwide aimed at developing a vaccine against VHS through different strategies including killed or attenuated vaccines, recombinant protein vaccines and DNA vaccines using VHSV glycoprotein (Kim et al, 2016). In Korea, a whole‐VHSV vaccine was approved in 2019, but it has not yet been approved for sale (National Institute of Fisheries Science in Korea, https://www.nifs.go.kr/adms).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of an optimized extract from licorice roots ( Glycyrrhiza uralensis fischer) against viral hemorrhagic septicemia virus in olive flounder ( Paralichthys olivaceus )

Lim

Joong-Kyeong

Jung

et al. 2021

Aquaculture Research

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Viral hemorrhagic septicemia causes significant economic losses for olive flounder (Paralichthys olivaceus) farms in Korea. The purpose of this study was to optimize extraction conditions for licorice (Glycyrrhiza uralensis roots) extract using the 23 full factorial design and thereby optimizing the antiviral activity against viral hemorrhagic septicemia virus (VHSV). The optimum conditions were ethanol concentration 100%, extraction temperature 40˚C and extraction time 5 h. Optimized extract (OE) prepared under these conditions showed potent antiviral activity against VHSV with a 95.2% CPE reduction at 75 µg/ml of OE, and a predictive capacity of 94%. Fish that received 250 and 500 mg/kg body weight/day of OE as either preventive or therapeutic administration had higher relative survival rates of 25 to 62.5% (p < 0.05) compared with VHSV‐infected control group. Active components of licorice, glycyrrhizin (GL) and glycyrrhetinic acid (GLA) showed antiviral activity against VHSV with 50% effective concentration values of 100.6 and 26.0 µM respectively. Besides, time course studies by plaque reduction assay showed that GLA exhibited a direct virucidal effect on VHSV or may inhibit the penetration and internalization of the virus to cells. These results suggest that OE may be used as an anti‐VHSV agent in aquaculture.

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Comparison of the efficacy of Poly(I:C) immunization with live vaccine and formalin-killed vaccine against viral hemorrhagic septicemia virus (VHSV) in olive flounder (Paralichthys olivaceus)

Cited by 22 publications

References 26 publications

B cells and their role in the teleost gut

B cells and their role in the teleost gut

Zebrafish as a model for Rhabdovirus infection and molecular mechanism of the immune response

Efficacy of an optimized extract from licorice roots ( Glycyrrhiza uralensis fischer) against viral hemorrhagic septicemia virus in olive flounder ( Paralichthys olivaceus )

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