Comparison of the hemostatic efficiency of Ankaferd Blood Stopper and fibrin glue on a liver laceration model in rats

Akarsu, Cevher; Kalaycı, Mustafa; Yavuz, Erkan; Özkara, Selvinaz; Gökçek, Berk; Özdenkaya, Yaşar; Yalçın, Orhan

doi:10.5505/tjtes.2011.38455

Cited by 8 publications

(6 citation statements)

References 25 publications

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“…ABS also has pleiotropic effects particularly in the tissue healing and has anti-infective properties [ 1 , 3 , 9 , 10 , 33 , 37 , 38 ]. The toxicological results of the present study have provided the basis for the future ABS clinical trials in the fields of clinical hemostasis, wound healing, burn treatment, and anti-infective and antineoplastic approaches [ 4 , 22 , 39 – 47 ]. Moreover, next-generation RBC-related hemostatics, such as ABS nanohemostat, have already been designated in the essential treatment of life-threatening bleedings by restoring physiological hemostasis via acting on RBCs [ 48 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

Qualitative/Chemical Analyses of Ankaferd Hemostat and Its Antioxidant Content in Synthetic Gastric Fluids

Koluman

Akar

Malkan

et al. 2016

BioMed Research International

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Introduction. Ankaferd hemostat (ABS) is the first topical haemostatic agent involving the red blood cell-fibrinogen interactions. The antihemorrhagic efficacy of ABS has been tested in controlled clinical trials. The drug induces the formation of an encapsulated complex protein web with vital erythroid aggregation. The aim of this study is to detect the essential toxicity profile and the antioxidant molecules inside ABS. Methods. The pesticides were analyzed by GC-MS and LC-MS. The determination by ICP-MS after pressure digestion was performed for the heavy metals. HPLC was used for the detection of mycotoxins. Dioxin Response Chemically Activated Luciferase Gene Expression method was used for the dioxin evaluation. TOF-MS and spectra data were evaluated to detect the antioxidants and other molecules. Results. TOF-MS spectra revealed the presence of several antioxidant molecules (including tocotrienols, vitamin E, tryptophan, estriol, galangin, apigenin, oenin, 3,4-divanillyltetrahydrofuran, TBHQ, thymol, BHA, BHT, lycopene, glycyrrhetinic acid, and tomatine), which may have clinical implications in the pharmacobiological actions of ABS. Conclusion. The safety of ABS regarding the presence of heavy metals, pesticides, mycotoxins, GMO and dioxins, and PCBs was demonstrated. Thus the present toxicological results indicated the safety of ABS. The antioxidant content of ABS should be investigated in future studies.

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Section: Discussionmentioning

confidence: 99%

Qualitative/Chemical Analyses of Ankaferd Hemostat and Its Antioxidant Content in Synthetic Gastric Fluids

Koluman

Akar

Malkan

et al. 2016

BioMed Research International

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“…Again, in another study, Karakaya et al exhibited its hemostatic efficacy by comparing suturing material in the rat model of partial liver resection (14). Akarsuet al found that ABS and fi brin glue have equal topical hemostatic effi cacy in the rat model of liver laceration (15).…”

Section: Discussionmentioning

confidence: 99%

Effects of Ankaferd Blood Stopper and calcium alginate in experimental model of hepatic parenchymal bleeding

Aydin¹,

Tuncal²,

Kilicoglu³

et al. 2015

BLL

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:Background:This experimental study compared the hemostatic effects of calcium alginate and Ankaferd Blood Stopper in hepatic parenchymal bleedings. Material and method:The study comprised 39 male Wistar albino rats (weight 230±30 g). Laceration model was created in the left lateral lobe of the liver. Standard cotton gauze that was impregnated 0.9% NaCl solution and Calcium alginate cover was compared to ABS tampon. The amount of preoperative bleeding, preoperative and postoperative Day 1 hematocrit levels, and the difference between them were assessed and statistically analyzed. Results: Comparing the hematocrit levels between the groups, we found that the amount of bleeding was signifi cantly higher in the control group versus the study groups (p<0.001). Histopathological examination revealed the portal area enlargement and biliary canaliculi proliferation. In the Ca 2+ Alginate group, it was observed that the fi bres were still present in the incision line with massive fi brotic area around. In the Ankaferd group, examination of the preparations revealed patchy focal necrosis areas but no fi brotic area. Conclusion:With this study, we demonstrated that both calcium alginate and Ankaferd have hemostatic effect in preventing hepatic parenchymal bleeding and that calcium alginate causes fi brosis in the liver, where ABS causes focal necrosis areas (Tab. 2, Fig. 4, Ref. 19). Text in PDF www.elis.sk.

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“…[7] Agents such as chitosan, ankaferd, coolclot, fastact, zeolite or algan hemostatic agent (AHA) are among them and they preferred in coagulopathic patients to reduce bleeding and the risk of infection. [8][9][10][11][12] Algan hemostatic agent liquid is a class III hemostatic agent (Certificate number: XXXX) that is derived from the standardized mixture of six different plants. Each of the plants that make up the AHA has a content that provides hemostasis in combinations.…”

Section: Introductionmentioning

confidence: 99%

Histopathological Effects of Algan Hemostatic Agent (AHA) in Liver Injury Model in Rats

Şener¹

2021

Hepatology Forum

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Background and Aim:In this study, we aimed to assess hemostatic and histopathological impacts of Algan hemostatic agent (AHA) with liver injury model. 2Materials and Methods: 10-12 week old 24 male rats were randomly divided into three equal groups(n=8) as control(physiological saline solution), AHA liquid and AHA powder. Total of three iatrogenic cut injury were performed on anterior surface of left liver lobe. After bleeding had started, sponges soaked with physiological saline, AHA liquid, AHA powder were pressed slightly on injured area for 20 seconds in corresponding groups, respectively. Bleeding duration was measured by timer. Bleeding unended after three consecutive applications was considered as failure. Animals were sacrificed on tenth minute of the procedure. Left liver lobes were removed for histopathological examination.Results: Bleeding control success rates of AHA liquid was significantly higher than AHA powder group and both forms were effective than physiological saline. Superficial thick granulation tissue with entrapped powder residue materials was detected in AHA powder group. Liver parenchyma was intact in liquid and powder groups. Conclusion:AHA is fast-acting and applicable hemostatic agent in liver bleeding model. However, further comparative studies in various organs are required.

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Comparison of the hemostatic efficiency of Ankaferd Blood Stopper and fibrin glue on a liver laceration model in rats

Cited by 8 publications

References 25 publications

Qualitative/Chemical Analyses of Ankaferd Hemostat and Its Antioxidant Content in Synthetic Gastric Fluids

Qualitative/Chemical Analyses of Ankaferd Hemostat and Its Antioxidant Content in Synthetic Gastric Fluids

Effects of Ankaferd Blood Stopper and calcium alginate in experimental model of hepatic parenchymal bleeding

Histopathological Effects of Algan Hemostatic Agent (AHA) in Liver Injury Model in Rats

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