Comparison of the preventive effects of slightly acidic HOCl mouthwash and CHX mouthwash for oral diseases

Abstract

The purpose of this study was to compare the preventive effects of the slightly acidic hypochlorous acid (HOCl) mouthwash and chlorhexidine (CHX) mouthwash as a chemical plaque control agent for oral diseases. This study was conducted for 15 patients who had no systemic disease among the patients who visited M Dental Clinic in Busan, South Korea, excluding the patients with incomplete data. The patients were divided into three groups: five patients in the 0.005% CHX (Bukwang Pharm Co., Ltd.) gargling group, five in the slightly acidic HOCl gargling group, and five in the saline gargling group. The patients were instructed to gargle with 15 ml of each mouthwash for 1 minute, and to then spit saliva for 1 min to remove the remaining gargling solution. Then the halitosis, O'Leary index, dental caries activity, bacterial species, and motility were measured. As a result, these decreased in the CHX gargling group compared to the saline gargling group, but the difference was not statistically significant (P>0.005), while there were significant decreases in the HOCl gargling group. The O'Leary index, Snyder test, bacterial motility, and Filamentous more distinctly and effectively decreased in the HOCl gargling group than in the CHX gargling group, showing statistically significant differences (p<0.05). Based on this study, CHX, which is currently widely used in dentistry, can be said to be inconvenient to use due to its strong fragrance and taste, and there have been many reports on the side effects on the oral cavity of its long-term use. Therefore, if HOCl, which is harmless to the human body and has an extensive sterilizing power, is used instead of CHX, safe and effective oral care will be achieved.

Electrolyzed Saline Targets Biofilm Periodontal Pathogens In Vitro

“…Biofilm SEM micrographs supported these findings. Similarly, microscopically, HOCl decreased periodontitis- and halitosis-related spirochetes and filamentous bacteria in supra- and subgingival plaque (Kim and Nam 2018).…”

“…Electrolyzed oxidizing solutions (EOSol) are generated through electrolyzing chloride-containing water, typically in the form of sodium chloride (NaCl), generating free chlorine in the form of hypochlorous acid (HOCl), hypochlorite ions (ClO–), and soluble chlorine gas (Cl 2 ), with broad-spectrum antibacterial activity (Huang et al 2008; Dube and Jain 2018; Kim and Nam 2018). In addition, oxygen radicals and reactive hydrogen are also generated (Shimada et al 2000; Ogunniyi et al 2019; Cárdenas et al 2022).…”

“…Mouthrinses can aid in preventing periodontal diseases when mechanical plaque control is challenging. In addition, using mouthrinses may enhance the effectiveness of periodontal therapy (Kim and Nam 2018).…”

The Comparison of Ketokonazol and Hypochlorous Acid (Hocl) Applications for the Treatment of The Fungal Infections (Dermatophytosis)

“…(Goto, 2015;Ateş, 2020). As for the usage areas in health services superficial skin infections, acute and chronic wound, antisepsis of the operation site before and after the operation, mastitis, metritis, rhinitis, sinusitis, ocular and oral lesions, skin burns can be exemplify (Hakim et al, 2015;Gray et al, 2016;Karabulut and Gülay, 2016;Fuentes, 2018;Kim and Nam, 2018;Kanclerz et al, 2019;Block and Rowan, 2020;Fam et al, 2020;Gold et al, 2020;Joachim, 2020).…”