Comparison of the prognostic values of selected inflammation based scores in patients with medullary thyroid carcinoma: A pilot study

Jiang, Ke; Lei, Jianyong; Li, Canjun; Shu, Kunpeng; Li, Wenbin; Zhang, Yuwei; Li, Zhihui; Gong, Renmin; Zhu, Junfei

doi:10.1002/jso.24683

Cited by 31 publications

(28 citation statements)

References 35 publications

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“…Some studies insist that elevated lymphocytes facilitate aggressive tumor behavior and thus result in reduced survival, and these are in accordance with our finding that elevated lymphocyte counts reflected a higher stage of PTC [ 25 , 28 , 29 ]. A similar positive correlation trend is also found in medullary thyroid carcinoma [ 30 ]. Our data may offer evidence of the association between lymphocytes and adverse invasive behavior in PTC.…”

Section: Discussionsupporting

confidence: 81%

Predictive values of the selected inflammatory index in elderly patients with papillary thyroid cancer

Wen

et al. 2018

J Transl Med

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BackgroundThe American Joint Committee on Cancer has recently revised the tumor-node-metastasis (TNM) staging system on thyroid cancer, which illustrated that the cut-off age for predicting mortality has elevated from 45 to 55 years old. We aimed to investigate the inflammation index based on hematological parameters to predict the clinical characteristics of elderly papillary thyroid cancer (PTC) patients with an inferior prognosis.MethodsWe retrospectively analyzed 558 patients newly diagnosed with PTC from January 2013 to December 2017, and 82 out of the 558 patients were over 55 years old. Receiver operating characteristic (ROC) study and univariate and multivariate logistic analysis was conducted to evaluate the diagnostic value of these preoperative inflammation indexes in PTC patients ≥ 55 years of age.ResultsElevated neutrophils were prognostic of bilaterality (area under the ROC curve (AUC) = 0.673, p = 0.023) and lymph node metastasis (AUC = 0.649, p = 0·020). Decreased mean platelet volume (MPV) and platelet distribution width (PDW) were prognostic of coexistence with Hashimoto’s thyroiditis (AUC = 0.736, p = 0.016; AUC = 0.721, p = 0.024). Elevated lymphocyte and lymphocyte-to-monocyte ratio (LMR) were prognostic of advanced TNM stage (AUC = 0.691, p = 0.029; AUC = 0.680, p = 0.040). Meanwhile, the logistic regression model further revealed that LMR ≥ 5.45 was an independent risk factor for the advanced TNM stage (odds ratio (OR) = 7.306, p = 0.036).ConclusionsThe preoperative neutrophils, lymphocytes, MPV, PDW, LMR were all prognostic. More importantly, the increased in LMR independently contributed to the advanced TNM stage of PTC patients ≥ 55 years.Electronic supplementary materialThe online version of this article (10.1186/s12967-018-1636-y) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 81%

Predictive values of the selected inflammatory index in elderly patients with papillary thyroid cancer

Wen

et al. 2018

J Transl Med

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“…These results are similar to those reported in studies by Luo et al that focused on histology in esophageal cancer [ 25 , 28 ], gastric cancer [ 29 ], lung cancer [ 10 ] and urothelial carcinoma [ 30 ]. In our previous study [ 31 ], we reported that hyperfibrinogenemia was associated with a higher rate of lymph node and capsule invasion in medullary thyroid carcinoma. To our knowledge, this is the first study to explore serum fibrinogen levels in PTC.…”

Section: Discussionmentioning

confidence: 99%

Using a nomogram based on preoperative serum fibrinogen levels to predict recurrence of papillary thyroid carcinoma

Lei

Gong

et al. 2018

BMC Cancer

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BackgroundHyperfibrinogenemia is increasingly being recognized as an important risk factor related to cancer stage, development and outcomes. We evaluated whether preoperative serum fibrinogen levels predict recurrence of papillary thyroid carcinoma (PTC).MethodsWe retrospectively collected data for 1023 PTC patients who underwent surgery at our institution from Aug 2014 to Aug 2016. In total, 414 patients (from Aug 2014 to Dec 2015) were used as the training set to build the model, and 609 patients (from Jan 2016 to Aug 2016) were used as the testing set to validate the model.ResultsIn the training set, PTC cases with high serum fibrinogen levels were more likely to have multiple PTCs (P = 0.001) and to exhibit surrounding tissue or organ invasion (both P < 0.01). Moreover, PTC patients with higher serum fibrinogen levels were also more likely to have an advanced tumor stage (T, P = 0.001) and distance metastasis (P < 0.001), and these patients had a significantly higher rate of postoperative PTC recurrence (P = 0.002). All of these findings were validated in the testing set. The results of univariate and multivariate analyses indicated that hyperfibrinogenemia was a risk factor for PTC recurrence. The identified risk factors were incorporated into a nomogram and validated using the testing set (C-index = 0.811, 95% CI: 0.762–0.871).ConclusionPTC cases with hyperfibrinogenemia are more likely to have an advanced TNM stage and have a higher rate of PTC recurrence. Our nomogram could be used to objectively and accurately predict PTC recurrence in a clinical setting.

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“…Meanwhile, emerging evidence indicates that host inflammation relates to cancer pathophysiology and progression 10‐13 . Systemic inflammatory markers (SIMs), which derive from the peripheral blood, such as neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte ratio (PLR), and lymphocyte‐to‐monocyte ratio (LMR), have been extensively investigated for diagnostic and prognostic value in a variety of solid tumors including thyroid carcinoma 14‐23 . Integrated indicators such as neutrophil‐platelet‐lymphocyte ratio (NPLR) and neutrophil‐monocyte‐lymphocyte ratio (NMLR) have been developed.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic and prognostic value of preoperative systemic inflammatory markers in anaplastic thyroid cancer

Zhang

Luo

Wang

et al. 2020

Journal of Surgical Oncology

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Background Easily accessible, generalized, and inexpensive methods are expected to differentiate anaplastic thyroid carcinoma (ATC) from advanced differentiated thyroid cancer (aDTC). We aimed to explore potential diagnostic and prognostic value of systematic inflammatory markers (SIMs) in ATC and aDTC. Methods About 22 ATC, 101 aDTC, and 100 matched early DTC patients were analyzed retrospectively. SIMs included the comprehensive index, neutrophil‐monocyte‐platelet‐to‐lymphocyte ratio (NMPLR) and the previously reported ones. Receiver operating characteristic, Kaplan‐Meier, and COX regression analyses were mainly conducted. Results NMPLR exhibited the highest area under the curve value 0.806 (P < .0001) to diagnose ATC from aDTC. NMPLR was identified as an independent risk factor for overall survival (OS) (hazard ratio [HR]: 47.821, 95% confidence interval [CI], 2.863‐798.765, P = .007) in ATC, as well as for OS (HR: 7.360, 95% CI, 1.620‐33.430, P = .010) and recurrence‐free survival (HR: 4.172, 95% CI, 1.139‐15.286, P = .031) in aDTC. Taken both refractory types (ATC and aDTC) together, NMPLR could independently predict OS (HR: 6.470; 95% CI, 2.134‐19.616; P = .001). Conclusion NMPLR is a generalized index. It showed excellent potential in differential diagnosis and survival prediction in refractory thyroid cancer. However, it needs to be validated in larger cohort and clinical practice.

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Comparison of the prognostic values of selected inflammation based scores in patients with medullary thyroid carcinoma: A pilot study

Abstract: PLR, fibrinogen, and PNI are all predictive. Specially, PLR is superior to other inflammation based scores in terms of prognostic ability.

Cited by 31 publications

References 35 publications

Predictive values of the selected inflammatory index in elderly patients with papillary thyroid cancer

Predictive values of the selected inflammatory index in elderly patients with papillary thyroid cancer

Using a nomogram based on preoperative serum fibrinogen levels to predict recurrence of papillary thyroid carcinoma

Diagnostic and prognostic value of preoperative systemic inflammatory markers in anaplastic thyroid cancer

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