Comparison of the Radial Compliance of Three Kinds of Vascular Prostheses and Pig’s Carotid Based on Dynamic-Simulated Condition

Shen, Gaotian; Jing, Lin; Zhang, Hongqi; Wang, Lu

doi:10.1007/978-3-642-29305-4_48

Cited by 3 publications

(8 citation statements)

References 4 publications

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“…Compliance, including circumferential and longitudinal compliance, plays a critical role in maintaining standard hemodynamic stability, especially for small diameter blood vessels which are extremely sensitive to the diameter changes. However, even for a woven PET vascular graft, the circumferential compliance can only reach 0.75% under 80–120 mmHg pressure . Despite this, it is higher than that of a standard commercial ePTFE one, 0.64%, while the circumferential compliance of a native blood vessel is around 5% .…”

Section: Discussionmentioning

confidence: 88%

“…Despite this, it is higher than that of a standard commercial ePTFE one, 0.64%, while the circumferential compliance of a native blood vessel is around 5% . In addition, a longitudinal strain of 50% was expected for a vascular graft to meet the longitudinal compliance of a native blood vessel . Undoubtedly, current vascular grafts do not meet these clinical requirements regarding high compliance yet.…”

Section: Discussionmentioning

confidence: 95%

“…However, even for a woven PET vascular graft, the circumferential compliance can only reach 0.75% under 80-120 mmHg pressure. 60 Despite this, it is higher than that of a standard commercial ePTFE one, 0.64%, 60 while the circumferential compliance of a native blood vessel is around 5%. 61 In addition, a longitudinal strain of 50% was expected for a vascular graft to meet the longitudinal compliance of a native blood vessel.…”

Section: Discussionmentioning

confidence: 96%

“…61 In addition, a longitudinal strain of 50% was expected for a vascular graft to meet the longitudinal compliance of a native blood vessel. 60 Undoubtedly, current vascular grafts do not meet these clinical requirements regarding high compliance yet. Therefore, researchers over the globe have been conducting more studies concerning the development of the innovative small diameter vascular grafts with high compliance, and biomedical hydrogels are appropriate candidates for their favorable elasticity.…”

Section: Discussionmentioning

confidence: 99%

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Surface modification of polyvinyl alcohol (PVA)/polyacrylamide (PAAm) hydrogels with polydopamine and REDV for improved applicability

Xing

et al. 2019

J Biomed Mater Res

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Developing a small‐diameter vascular graft with a satisfactory performance in terms of mechanical and biological properties remains a challenging issue because of comprehensive requirements from clinical applications. Polyvinyl alcohol (PVA)/polyacrylamide (PAAm) hydrogels exhibit many desirable characteristics for small‐diameter vascular grafts because of their tunable mechanical properties, especially high compliance. However, poor cells adhesion hinders their application for endothelialization in situ. Therefore, in the present work, polydopamine (PDA) and tetrapeptide Arg‐Glu‐Asp‐Val (REDV) were used to functionalize the hydrogels surface and improve cells adhesion. A series of characterizations were systematically conducted to examine the applicability of coated hydrogels to small‐diameter vascular grafts. Results showed that bare and coated hydrogels have appropriate structural stability, and no significant differences in tensile properties could be found after being coated with PDA or PDA‐REDV. The hydrophilicity of the hydrogels decreased with the coatings of PDA and especially PDA‐REDV to improve protein adsorption, porcine iliac artery endothelial cells (PIECs) adhesion, viability, proliferation, and spreading on the hydrogels. Lower hemolysis percentages and higher blood clotting index values were attained for the hydrogels, suggesting their satisfactory hemocompatibility. Overall, the present work provided insights into the development of a novel hydrogel‐based small‐diameter vascular graft. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 108B:117–127, 2020.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Surface modification of polyvinyl alcohol (PVA)/polyacrylamide (PAAm) hydrogels with polydopamine and REDV for improved applicability

Xing

et al. 2019

J Biomed Mater Res

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“…The suture retention force was tested according to Standard ISO 7198: 1998 [16]. Furthermore, the scaffold's elastic recovery after compression was determined on a Laizhou Electronic Instrument (Model YG061) radial compression apparatus.…”

Section: Characterization Methodsmentioning

confidence: 99%

Degradable/non-degradable polymer composites for in-situ tissue engineering small diameter vascular prosthesis application

Wang

Abedalwafa

et al. 2014

Bio-Medical Materials and Engineering

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Various tissue-engineered vascular grafts have been studied in order to overcome the clinical disadvantages associated with conventional prostheses. However, previous tissue-engineered vascular grafts have possessed insufficient mechanical properties and thus have generally required either preoperative cellular manipulation or the use of bioreactors to improve their performance. In this study, we focused on the concept of in situ cellularization and developed a tissueengineered vascular graft with degradable/ non-degradable polymer composites for arterial reconstruction that would facilitate the renewal of autologous tissue without any pretreatment. Additionally, these composites are designed to improve the mechanical performance of a small-diameter vascular prosthesis scaffold that is made from a flexible membrane of poly(εcaprolactone) (PCL). The PCL scaffold was reinforced by embedding a tubular fabric that was knitted from polyethylene terephthalate (PET) yarns within the freeze-dried composite structure. Adding this knitted fabric component significantly improved the mechanical properties of the composite scaffold, such as its tensile strength and initial modulus, radial compliance, compression recovery, and suture retention force. Finally, this reinforced composite structure is a promising candidate for use as a tissue-engineered scaffold for a future small diameter vascular prosthesis.

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Mechanical and Biocompatibility Performance of Bicomponent Polyester/Silk Fibroin Small-Diameter Arterial Prostheses

Yang

Wang

Guan

et al. 2015

Journal of Applied Biomaterials & Functional Materials

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The bicomponent polyester/silk fibroin samples had superior bursting strength, circumferential strength and suture retention strength compared with a commercial small-diameter arterial prosthesis made from ePTFE. In addition, these prototype samples had greater suture retention strengths than a dog femoral artery, which indicates that they have adequate biostability for clinical use. While their amount of radial compliance was superior to that of the ePTFE commercial graft control, it did not match that of a natural artery. So there is still a need for future improvement in compliance. All of the woven prototypes had water permeability values between 26 and 180 ml/(cm(2)*min), which confirms that none of these arterial prostheses needs to be preclotted at the time of implantation. The biocompatibility of the woven prototypes was evaluated using porcine endothelial cells and an MTT assay. Their cytocompatibility was found to be superior to the ePTFE commercial control, and the level of cell attachment was observed to increase on these prototypes woven with a higher silk fibroin content.

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Comparison of the Radial Compliance of Three Kinds of Vascular Prostheses and Pig’s Carotid Based on Dynamic-Simulated Condition

Cited by 3 publications

References 4 publications

Surface modification of polyvinyl alcohol (PVA)/polyacrylamide (PAAm) hydrogels with polydopamine and REDV for improved applicability

Surface modification of polyvinyl alcohol (PVA)/polyacrylamide (PAAm) hydrogels with polydopamine and REDV for improved applicability

Degradable/non-degradable polymer composites for in-situ tissue engineering small diameter vascular prosthesis application

Mechanical and Biocompatibility Performance of Bicomponent Polyester/Silk Fibroin Small-Diameter Arterial Prostheses

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