Comparison of the safety and immunogenicity of a pneumococcal conjugate with a licensed polysaccharide vaccine in human immunodeficiency virus and non-human immunodeficiency virus-infected children

Abstract

We conclude that antibody responses to natural infection, PCV and particularly PPV are poorer in HIV-infected than in non-HIV-infected children. PCV is as safe as and more immunogenic than the currently licensed PPV among HIV-infected and non-HIV-infected children.

Priming of Immunological Memory by Pneumococcal Conjugate Vaccine in Children Unresponsive to 23-Valent Polysaccharide Pneumococcal Vaccine

“…The analysis of these data confirmed our results with the restriction of smaller group sizes (Table 5). This better immunogenicity of PCV compared to PPV beyond infancy has also been suggested elsewhere (21,39). Induction of immunological memory after priming with a pneumococcal conjugate vaccine had previously also been shown for infants and patients with HodgkinЈs disease after treatment (9,15).…”

Up-Regulation of CD40 Ligand and Induction of a Th2 Response in Children Immunized with Pneumococcal Polysaccharide Vaccines

“…This lack of response can be overcome by conjugating the polysaccharide to a protein carrier. Several experimental pneumococcal conjugate vaccines have recently been developed (1,2,9,27). We have previously shown that the CRM197-heptavalent pneumococcal conjugate vaccine induced an IgG antibody response in pa-tients with recurrent infections who had failed to mount an adequate response to the polysaccharide vaccine (28).…”

Preventing opportunistic infections among human immunodeficiency virus-infected adults in African countries.

“…Pneumococcal conjugate vaccines have been shown to be immunogenic among children, including those with HIV infection 67 and efficacy studies in children are in progress in South Africa and The Gambia. Conjugate vaccines may also hold promise for HIV-infected adults and need to be evaluated.…”