Comparison of the sensitivity of the EULAR / ACR 2019 and SLICC 2012 classification criteria in a Colombian population with systemic lupus erythematosus

Guavita-Navarro, Diana; Gallego-Cardona, Laura; Arredondo, Ana María; Cubides, Héctor; Cajamarca-Barón, Jairo; Ibáñez, Claudia; Escobar, Alejandro; Rojas-Villarraga, Adriana

doi:10.1016/j.jtauto.2021.100133

Cited by 9 publications

(8 citation statements)

References 37 publications

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“…Nonetheless, as noted in the materials and methods, all patients were checked for strict compliance with SLICC/2012 classification criteria, as is applied at rheumatology center for SLE diagnosis. Although EULAR/ACR 2019 were not used, their sensibility has been shown to be similar as SLICC/2012 criteria [ 56 , 57 ] but there are differences on specificity, therefore could cause bias in the study. Also, the use of secondary sources of data collection leads to potential biases related to patient registries.…”

Section: Discussionmentioning

confidence: 99%

Polyautoimmunity in systemic lupus erythematosus patients: New insights from a cross-sectional study

Santos-Moreno¹,

Arias-Aponte²,

Rodríguez-Vargas³

et al. 2023

Journal of Translational Autoimmunity

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Section: Discussionmentioning

confidence: 99%

Polyautoimmunity in systemic lupus erythematosus patients: New insights from a cross-sectional study

Santos-Moreno¹,

Arias-Aponte²,

Rodríguez-Vargas³

et al. 2023

Journal of Translational Autoimmunity

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“…Pacientes cuja duração da doença é inferior a 5 anos, os critérios do SLICC 2012 terão melhor desempenho na classificação de pacientes. 22 .…”

Section: Sensibilidade E Especificidade Dos Sistemas De Classificação Dounclassified

“…19,21 Por exemplo, no caso de pacientes com doença precoce e uniorgânica, são sugeridos critérios SLICC. 20,22 . Fonte: Autores…”

Section: Sensibilidade E Especificidade Dos Sistemas De Classificação Dounclassified

Lúpus eritematoso sistêmico com fator antinuclear (FAN) negativo: um desafio no diagnóstico

Pacheco¹,

Pulla²,

Ortega³

et al. 2023

Braz. J. Hea. Rev.

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O lúpus eritematoso sistêmico (LES) é uma doença auto-imune que afeta 20 a 150 pessoas por 100.000 habitantes, caracterizada pela produção de auto-anticorpos, sendo os principais anticorpos envolvidos na patofisiologia desta doença os anticorpos antinucleares conhecidos como fator antinúcleo (FAN). O FAN positivo é agora considerado o critério de entrada para a classificação dos pacientes com FAN negativo, o que representa um desafio diagnóstico para aqueles com FAN negativo, uma entidade clínica descrita desde 1976 com uma prevalência de 2-20%. Apesar dos avanços nas técnicas de identificação do FAN, há vários fatores do paciente como idade, atividade da doença, uso de glicocorticóides, proteinúria, infecção e/ou sepse, que levam à negatividade de anticorpos no diagnóstico; assim como diferentes fatores técnicos ao processar o FAN por imunofluorescência indireta (IFI). Esta revisão aborda critérios de classificação do LES, técnicas de identificação do FAN, causas de negatividade e outros métodos de diagnóstico para aqueles pacientes com anticorpos antinucleares negativo e LES clínico, com o objetivo de fornecer informações aos profissionais de saúde que permitam o diagnóstico e tratamento oportuno dos pacientes com esta patologia, melhorando assim seu prognóstico e qualidade de vida.

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“…We have identi ed all of patients with SLE/ANA+, who at least have one test of the TB-IGRA assay during 2018 to 2020. All the subjects with SLE are met the Systemic Lupus Erythematosus International Collaborating Clinics (SLICC) criteria for SLE classi cation (10). In this study, the SLE disease activity index (SLEDAI) and the TB-IGRA assay were matched with their clinical parameters and laboratory diagnosis acquired on the same day.…”

Section: Sle Subjectsmentioning

confidence: 99%

Assay for interferon gamma release as a novel marker in pediatric patients with systemic lupus erythematosus

Zhang

Tian

et al. 2022

Preprint

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Background: The interferon-gamma (IFN-γ) release assay (IGRA) is an important laboratory diagnosis for latent Mycobacterium tuberculosis (TB) infection. The TB-IGRA measures the release of IFN-γ from peripheral blood cells, who are exposed to TB antigen (Ag), mitogen (MT), or negative/nil control (NL) in vitro. While, an exceptional higher TB Ag-NL level will reflect an elevation of peripheral lymphocytes released IFN-γ in a same condition. Therefore, we found that the elevated levels of TB Ag-NL could become a new biomarker for the diagnosis and treatment of pediatric systemic lupus erythematosus (SLE) patients. Methods: We have analyzed the clinical data of 776 children who are underwent TB-IGRA testing in the Department of Allergy and Rheumatology of Guangzhou Women and Children's Medical Center from 2018 to 2020. To investigate the association between TB Ag-NL and SLE, we have analyzed the clinical data of 47 SLE patients and TB Ag-NL testing results, and then evaluated the association between TB Ag-NL and SLE disease activity. Results: The TB Ag-NL levels were significantly higher in patients with active SLE than those in inactive SLE (p=0.0002). The TB Ag-NL levels were positively correlated with the SLE disease activity index (SLEDAI) and laboratory diagnosis parameters. The mean value of TB Ag-NL in SLE patients (0.04191 ± 0.07955, IU/mL) were significantly higher than those in patients with juvenile dermatomyositis (JDM) (0.0158 ± 0.0337, IU/mL, p=0.036), juvenile idiopathic arthritis (JIA) (0.0162 ± 0.0388, IU/mL, p=0.001), and healthy controls (HC) (0.0001 ± 0.0027, IU/mL, p=0.0003). Therefore, the elevated TB Ag-NL levels could serve as a potential diagnostic biomarker of SLE, especially for the active SLE. Conclusion: The detection of IFN-γ release levels by the TB-IGRA may be useful to assess SLE disease activity in pediatric patients with active SLE.

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Comparison of the sensitivity of the EULAR / ACR 2019 and SLICC 2012 classification criteria in a Colombian population with systemic lupus erythematosus

Cited by 9 publications

References 37 publications

Polyautoimmunity in systemic lupus erythematosus patients: New insights from a cross-sectional study

Polyautoimmunity in systemic lupus erythematosus patients: New insights from a cross-sectional study

Lúpus eritematoso sistêmico com fator antinuclear (FAN) negativo: um desafio no diagnóstico

Assay for interferon gamma release as a novel marker in pediatric patients with systemic lupus erythematosus

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