Comparison of the trabecular meshwork length between open and closed angle with evaluation of the scleral spur location

Choi, Wungrak; Lee, Min Woo; Kang, Hyun Goo; Lee, Hye Sun; Bae, Hyoung Won; Kim, Chan Yun; Seong, Gong Je

doi:10.1038/s41598-019-43315-2

Cited by 13 publications

(13 citation statements)

References 20 publications

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“…In the present study, our goal was to evaluate the previously suggested theory that there might be an association between the prevalence of glaucoma and TM length by comparing TM lengths of a South Korean population with those of other ethnic populations. Based on previous studies that have reported differences in TM length between open- and closed-angle patients, we compensated the TM length data of the South Korean patients with the corresponding open- and closed-angle ratios of each ethnic group in the previously discussed American study for a more accurate comparison [ 10 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is widely known that anterior chamber depth is affected by race and ethnicity, and since AXL, ACD, and spherical equivalents are all closely related to each other, it can be assumed that TM length will be influenced by these factors [ 12 , 20 , 21 , 22 ]. It is also widely discussed about the prevalence of glaucoma (especially angle closure glaucoma) associated with different ethnicities with different angular parameters, including AXL, ACD, and spherical equivalents [ 7 , 8 , 18 , 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Standard protocols for TM length measurement were used as described previously [ 12 ]. Briefly, TM length was measured in the nasal and temporal sides of the eye using AS-OCT by manually selecting 3 and 9 o’clock positions as the nasal and temporal positions, respectively.…”

Section: Methodsmentioning

confidence: 99%

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Investigating the Relationship between Glaucoma Prevalence and Trabecular Meshwork Length

Choi

Cho

Kim

et al. 2021

JCM

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Glaucoma is one of the most common causes of blindness worldwide, but the risk factors of glaucoma are yet to be fully understood. We investigated the relationship between the prevalence of glaucoma and trabecular meshwork (TM) length by comparing the mean TM length of a South Korean population with that of another ethnic population. We included 250 eyes of 125 patients who underwent anterior segment optical coherence tomography at Yonsei University Gangnam Severance Hospital between January 2015 and December 2017. We measured the distance from the scleral spur to Schwalbe’s line in patients with open and closed angles and calculated the TM length using the open- and closed-angle ratios in the general population. The mean TM length of the patients in our study was 752 ± 116 μm. Considering the compensated data, the estimated true mean TM length in the Korean population was 793 ± 76 μm, which was similar to the mean TM length of a previously evaluated Hispanic population, but differed significantly from those of previously evaluated Asian (Chinese), Caucasian, and African-American populations (p < 0.05). Our results support the hypothesis that the development of glaucoma would be affected by TM length.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Investigating the Relationship between Glaucoma Prevalence and Trabecular Meshwork Length

Choi

Cho

Kim

et al. 2021

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“…Therefore, we randomly selected adult patients with open anterior chamber angle and compared their TM heights after categorising them into their age groups to indirectly evaluate possible changes in TM height. Because there is a known difference between the open angle and closed angle TM heights, for a more accurate comparison, we excluded patients with closed angles and performed the study only on patients with open angles 6 .…”

Section: Discussionmentioning

confidence: 99%

“…Standard protocols for TM height measurement that have been described previously were used 6 . Briefly, TM height was measured in the nasal and temporal sides of the eye using AS-OCT by manually selecting the 3 and 9 o' clock positions as the nasal and temporal positions, respectively.…”

Section: As-oct Measurements All Patients Included In This Study Undmentioning

confidence: 99%

Evaluation of the Relationship Between Age and Trabecular Meshwork Height to Predict the Risk of Glaucoma

Choi

Bae

Cho

et al. 2020

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this study evaluated age-related trabecular meshwork (tM) height variations in the eyes of adults in different age groups. We hypothesised that a reduction in TM occurs with increasing age. This retrospective, cross-sectional, observational study was conducted at Yonsei University Gangnam Severance Hospital between January 2015 and June 2019. We randomly included 250 eyes of 125 patients who underwent anterior segment optical coherence tomography (AS-OCT). The distance from the scleral spur to Schwalbe's line in patients with normal open anterior chamber angle was measured using AS-OCT. Results were stratified based on patients' age group-≤40, 41-50, 51-60, 61-70, 71-80, and 81-92 years. Thereafter, the results were compared among the age groups. The mean TM height of the patients was 770.929 ± 76.776 μm. TM height was 853.188 ± 94.117 μm in patients aged ≤40 years; it was 815.309 ± 75.723, 798.115 ± 66.040, 770.942 ± 52.774, 726.716 ± 63.979, and 715.968 ± 63.403 μm in patients aged 41-50, 51-60, 61-70, 71-80, and 81-92 years, respectively. The tM height tended to decrease with increasing age (p < 0.001). TM height was significantly shorter in older patients than in younger ones. Therefore, TM height may change with age and may contribute to increased glaucoma risk and prevalence. Scientific RepoRtS | (2020) 10:7115 | https://doi.Mean TM height categorised by age and sex. The mean TM height of the patients in our study was 770.929 ± 76.776 μm. The mean TM height among men was 764.169 ± 85.300 μm and that among women was 776.938 ± 67.120 μm; there was no significant difference between the two groups (P = 0.1911). The mean TM height of patients aged ≤40 years was 853.188 ± 94.117 μm and those of patients aged 41-50, 51-60, 61-70, 71-80, and 81-92 years were 815.309 ± 75.723 μm, 798.115 ± 66.040 μm, 770.942 ± 52.774 μm, 726.716 ± 63.979 μm, and 715.968 ± 63.403 μm, respectively. TM height tended to decrease with increasing patient age (P < 0.001).These results were validated with post-hoc analysis using the least significant difference (no correction value) and Bonferroni correction (correction value) methods (Table 2 and Fig. 1).Scientific RepoRtS | (2020) 10:7115 | https://doi.

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The anterior scleral thickness in eyes with primary open-angle glaucoma

Yan

Chen

Zhou

2022

Graefes Arch Clin Exp Ophthalmol

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Purpose To investigate the anterior scleral thickness (AST) and its associations with Schlemm’s canal (SC) area, trabecular meshwork (TM) thickness and length, and scleral spur (SS) length in healthy and primary open-angle glaucoma (POAG) groups. Methods Thirty-five eyes of 35 healthy subjects and 23 eyes of 23 patients with POAG were included. The AST, SC area, TM thickness and length, and SS length were measured using swept-source optical coherence tomography. AST was measured at 0 mm (AST0), 1 mm (AST1), 2 mm (AST2), and 3 mm (AST3) from SS. Associations between AST and SC area, TM thickness and length, and SS length were also estimated. Results AST0 (728.84 ± 99.33 vs. 657.39 ± 67.02 μm, p < 0.001), AST1 (537.79 ± 79.55 vs. 506.83 ± 57.37 μm, p = 0.038), AST3 (571.09 ± 79.15 vs. 532.13 ± 59.84 μm, p = 0.009), SC area (6304.26 ± 1238.72 vs. 4755.64 ± 1122.71 μm2, p < 0.001), TM thickness (107.21 ± 31.26 vs. 94.51 ± 24.18 μm, p = 0.035), TM length (736.20 ± 141.85 vs. 656.43 ± 127.03 μm, p = 0.004), and SS length (219.89 ± 50.29 vs. 174.54 ± 35.58 μm, p < 0.001) were significantly greater in healthy group than in POAG group. In addition, SC area, TM thickness, and SS length were significantly and positively associated with AST0 in the healthy group, whereas no similar associations were observed in the POAG group. Conclusions Compared with the healthy group, AST was significantly thinner in the POAG group, which also had smaller SC and TM dimensions. Moreover, the SC area, TM thickness, and SS length were significantly and positively associated with AST in the healthy group. Thus, AST might play an important role in maintaining TM and SC morphology and further in the pathogenesis of POAG.

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Comparison of the trabecular meshwork length between open and closed angle with evaluation of the scleral spur location

Cited by 13 publications

References 20 publications

Investigating the Relationship between Glaucoma Prevalence and Trabecular Meshwork Length

Investigating the Relationship between Glaucoma Prevalence and Trabecular Meshwork Length

Evaluation of the Relationship Between Age and Trabecular Meshwork Height to Predict the Risk of Glaucoma

The anterior scleral thickness in eyes with primary open-angle glaucoma

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