Comparison of Tinidazole Given as a Single Dose and on 2 Consecutive Days for the Treatment of Nonspecific Bacterial Vaginosis

Ekgren, Josef; Norling, B.; Degré, Miklos; Midtvedt, Tore

doi:10.1159/000293712

Cited by 16 publications

(9 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Trials evaluating oral regimens of 1–2 g daily for 1–5 days have given favorable results 30. Tinidazole was licensed recently in the US for the treatment of BV 31…”

Section: Antibiotic Therapymentioning

confidence: 99%

Antibacterial treatment of bacterial vaginosis: current and emerging therapies

Ménard¹

2011

IJWH

View full text Add to dashboard Cite

Bacterial vaginosis is a common cause of malodorous vaginal discharge. It is also associated with sexually transmitted infections and adverse pregnancy outcomes. The magnitude of the gynecological and obstetrical consequences has stimulated therapeutic research and led to the testing of several therapies. The objective of this work is to present the currently available therapeutic strategies for the treatment of bacterial vaginosis and associated recommendations, and discuss the emerging therapies.

show abstract

“…Trials evaluating oral regimens of 1–2 g daily for 1–5 days have given favorable results 30. Tinidazole was licensed recently in the US for the treatment of BV 31…”

Section: Antibiotic Therapymentioning

confidence: 99%

Antibacterial treatment of bacterial vaginosis: current and emerging therapies

Ménard¹

2011

IJWH

View full text Add to dashboard Cite

show abstract

“…In both the reports comparing a single 2g dose of tinidazole to a single 2g dose of metronidazole, tinidazole produced higher efficacy rates. A report by Ekgren13 which compared a single 2g dose of tinidazole to a 2g × 2 day dose of tinidazole demonstrated higher efficacy with the 2 day dosing regimen. In that randomized, double-blind study report the 2 day dose produced an efficacy rate of 74% vs. 51% efficacy for the single 2g dose with only a small increase in the reported side effects (44% vs. 39%).…”

Section: Discussionmentioning

confidence: 99%

Tinidazole vs metronidazole for the treatment of bacterial vaginosis

Schwebke

Desmond

2011

American Journal of Obstetrics and Gynecology

View full text Add to dashboard Cite

Objective-To compare the efficacy of two different doses of tinidazole with metronidazole for treatment of bacterial vaginosis and compare side effects of the drugs.Study design-Women were randomized to metronidazole 500 mg BID, tinidazole 500 mg BID, or tinidazole 1 gm BID all for 7 days. Follow-up visits were conducted at day 14 and day 28.Results-593 women were enrolled. There were no significant differences between the treatment arms. Overall cure rates were 76.8% at 14 days and 64.5% at one month. Women who admitted to engaging in sexual intercourse during the study were significantly more likely to have BV at follow-up. There were no significant differences in adverse events across treatment arms.Conclusions-There were no differences in cure rates between metronidazole and either of the tinidazole dosing regimens studied. In addition, there were no important differences in the side effect profiles of metronidazole and tinidazole.

show abstract

“…It is better tolerated than metronidazole 25,26 and very cheap (wholesale price per 2 g dose ≈ US$ 0.07). Studies of singlemdose tinidazole in women with BV have shown a wide range of effectiveness (51-97%) [27][28][29][30] but used different definitions of BV and cure. Experts now agree that the goal of BV treatment is symptomatic relief.…”

Section: Discussionmentioning

confidence: 99%

The syndromic management of vaginal discharge using only single-dose treatments: a randomized controlled trial in West Africa

Pépin

Sobela²,

Khonde³

et al. 2006

Bull World Health Organ

View full text Add to dashboard Cite

Objective To evaluate whether single-dose treatments are as effective as standard therapy in the syndromic management of vaginal discharge. Methods A randomized controlled effectiveness trial compared single-dose tinidazole plus fluconazole (TF) with treatment for 7 days with metronidazole plus 3 days of treatment with vaginal clotrimazole (MC) among 1570 women presenting with vaginal discharge at primary health care institutions in Ghana, Guinea, Mali and Togo. Participants were randomly allocated to one of the two treatments by research nurses or physicians using precoded envelopes. Effectiveness was assessed by symptomatic response on day 14. Clinical identifier ClinicalTrials.gov NCT00313131. Findings The two treatment regimens had similar effectiveness: complete resolution was seen in 66% (TF) and 64% (MC) and partial resolution in 33% (TF) and 34% (MC) of participants (P = 0.26). Effectiveness was similar among subgroups with vulvovaginal candidiasis, Trichomonas vaginalis vaginitis or bacterial vaginosis. The two treatment regimens had a similar effectiveness among human immunodeficiency virus (HIV)-infected (TF: n = 76, 71% complete resolution, 28% partial; MC: n = 83, 72% complete resolution, 25% partial, P = 0.76) and HIV-uninfected women (TF: n = 517, 68% complete, 32% partial; MC: n = 466, 65% complete, 33% partial, P = 0.20). Cervical infections with Neisseria gonorrhoeae, Chlamydia trachomatis and Mycoplasma genitalium were uncommon among women not involved in sex work, were associated with bacterial vaginosis or T. vaginalis vaginitis, and did not alter response to treatment with agents active against vaginal infections. Four-fifths of women not relieved by a single dose of TF had a favourable response when MC was administered as second-line treatment. Conclusion Single-dose TF is as effective as multiple-dose MC in the syndromic management of vaginal discharge, even among women with HIV-infection. Given its low price and easier adherence, TF should be considered as a first-line treatment for vaginal discharge syndrome. Voir page 736 le résumé en français. En la página 736 figura un resumen en español.

show abstract

Comparison of Tinidazole Given as a Single Dose and on 2 Consecutive Days for the Treatment of Nonspecific Bacterial Vaginosis

Cited by 16 publications

References 5 publications

Antibacterial treatment of bacterial vaginosis: current and emerging therapies

Antibacterial treatment of bacterial vaginosis: current and emerging therapies

Tinidazole vs metronidazole for the treatment of bacterial vaginosis

The syndromic management of vaginal discharge using only single-dose treatments: a randomized controlled trial in West Africa

Contact Info

Product

Resources

About