2008
DOI: 10.1128/cvi.00364-07
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Comparison of Two Commercially Available Gamma Interferon Blood Tests for Immunodiagnosis of Tuberculosis

Abstract: We evaluated the T-SPOT.TB and Quantiferon-TB Gold In tube (QFN-G-IT) tests for diagnosing Mycobacterium tuberculosis infection. T-SPOT.TB was more sensitive than QFN-G-IT in diagnosing both active and latent infection. Both gamma interferon tests were unaffected by prior Mycobacterium bovis BCG vaccination. Among children who were not BCG vaccinated but had a positive tuberculin skin test, QFN-G-IT was negative in 53.3% of cases, and T-SPOT.TB was negative in 50% of cases.

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Cited by 122 publications
(64 citation statements)
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“…Four studies were from intermediate-burden countries (South Korea [55], Lithuania [59], Iran [63] and Turkey [72]) and three studies were from high-burden countries (India [56], South Africa [61] and Vietnam [65]). Seven studies were based solely on paediatric cohorts [39,51,54,59,73,75] and three studies [47,57,61] included children in the study population.…”
Section: Ppv For Progressionmentioning
confidence: 99%
“…Four studies were from intermediate-burden countries (South Korea [55], Lithuania [59], Iran [63] and Turkey [72]) and three studies were from high-burden countries (India [56], South Africa [61] and Vietnam [65]). Seven studies were based solely on paediatric cohorts [39,51,54,59,73,75] and three studies [47,57,61] included children in the study population.…”
Section: Ppv For Progressionmentioning
confidence: 99%
“…In a number of contact investigations, substantially fewer BCG unvaccinated subjects had positive IGRA results compared with positive tuberculin skin test results [74,86,[89][90][91][92][93][94][95][96][97][98][99]. Comparability between the two IGRAs was generally good, whereas the agreement between tuberculin skin test and IGRA was poor, owing to false-positive tuberculin skin test results in BCG-vaccinated subjects or, based on studies among BCG unvaccinated subjects, to lower sensitivity of IGRA for detection of infections acquired in the past.…”
Section: Sectionmentioning
confidence: 99%
“…44 Results of both IFN-γ-based tests are unrelated to the BCG-vaccination status, which contributes to their high specificity. 4,7 Discordant results between these tests and TST are frequently found. 7,[45][46][47][48] In a study conducted in Barcelona (Spain), 7 among BCG-unvaccinated children, 60% and 57% of those with positive TST had negative QF-IT and T-SPOT.TB respectively.…”
Section: Paediatric Populationmentioning
confidence: 99%
“…4,7 Discordant results between these tests and TST are frequently found. 7,[45][46][47][48] In a study conducted in Barcelona (Spain), 7 among BCG-unvaccinated children, 60% and 57% of those with positive TST had negative QF-IT and T-SPOT.TB respectively. Latorre et al 49 reported that 48% of children with TST positive and negative T-SPOT.TB had sensitized T cells against Mycobacterium avium sensitins.…”
Section: Paediatric Populationmentioning
confidence: 99%
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