Comparison of two derivatization-based methods for solid-phase microextraction–gas chromatography–mass spectrometric determination of bisphenol A, bisphenol S and biphenol migrated from food cans

Abstract

An environmentally friendly sample pretreatment system based on solid-phase microextraction (SPME) for the sensitive determination of bisphenol A (BPA), bisphenol S (BPS) and biphenol (BP) is described. Two derivatisation reactions to obtain volatile derivatives are compared. Derivatisation with acetic anhydride (AA) was performed in situ in a 5-mM Na(2)CO(3)/NaHCO(3) buffer solution and analytes were extracted by direct immersion (DI) using a PA fibre (85 microm) at 90 degrees C for 40 min with stirring at 1,500 rpm. For derivatisation with bis-(trimethylsilyl)trifluoroacetamide (BSTFA), the analytes were first extracted by DI using the PA fibre at 70 degrees C for 40 min with stirring at 500 rpm. The fibre was then removed, dried in a nitrogen stream for 2 min and introduced into the headspace of BSTFA at 50 degrees C for 30 s. After derivatisation, the analytes were desorbed in the injection port of the GC in the splitless mode at 280 degrees C for 4 min. The separation was carried out by coupling gas chromatography with mass spectrometry in the selected ion monitoring mode, GC-MS(SIM). The method allowed the determination of the migrating levels of bisphenols found in food cans, and it was validated for linearity, detection and quantitation limits, selectivity, accuracy and precision. Detection limits ranged from 3 to 16 pg mL(-1), depending on the compound, at a signal-to-noise ratio of 3. Recoveries obtained for spiked samples were satisfactory for all compounds. Levels of BPA were higher than those of BPS and the lowest contents were found for BP.

Bisphenol S instead of bisphenol A: a story of reproductive disruption by regretable substitution - a review

“…In the USA, Korea, Vietnam, Japan, and China (Liao et al 2012c), BPS has been detected in several different "BPA free" paper products, including receipts and paper money (Liao et al 2012a). The presence of BPS has been determined in tinned foodstuffs (Vinas et al 2010). The occurrence of BPS has also been determined in indoor dust (Liao et al 2012b), in fluvial water (Ike et al 2006), surface water, and waste waters (Song et al 2014) (Table 2).…”

Analytical tools for identification of non-intentionally added substances (NIAS) coming from polyurethane adhesives in multilayer packaging materials and their migration into food simulants

“…Félix et al [21] used solidphase microextraction in headspace mode (HS-SPME) and GC-MS to identify the compounds from irradiated and nonirradiated multilayer polyamide 6 films. Other method based on derivatization followed by SPME-GC-MS for the determination of bisphenol A, bisphenol S, and biphenol migrated from food cans was also described [22]. Also, HS-SPME and GC with flame photometric detection has been reported for determination of organotin stabilizers in poly(vinyl chloride) products [23].…”

Bisphenol Compounds on Human Reproduction Health

“…[47][48][49] Receipts, paper products, and many canned food and soft drinks were found to have BPS and BPF. [50][51][52][53][54][55][56][57] In USA, BPF and BPS were detected in most of the human urine samples, albeit less frequent and lower concentrations than BPA in the same sample. 58,59 Low concentration of BPS was detected in some serum samples of pregnant women and the cord blood of the sibling, 60 suggesting BPS could also cross the placenta.…”