Comparison study of the response with botulinum toxin muscle injection in the ICR mice from three different sources

Seo, Min–Soo; Kim, Young–In; Kang, Kyung-Ku; Oh, Se‐Kyung; Sung, Soo-Eun; Jung, Young-Suk; Cho, Joon Yong; Song, Han-Jung; Hwang, Dae Youn; Park, Sang-Joon; Kim, Kil Soo

doi:10.1186/s42826-019-0010-4

Cited by 6 publications

(8 citation statements)

References 26 publications

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“…This study also evaluated the hematological effects of BOTOX injections, and we found a significant decline in Hb level in the group receiving "only BOTOX." In agreement with our findings, a recent investigation into the effect of BoNT/A injections on mice showed a significant decrease in RBC count, Hb level, and hematocrit (24). However, the reasons for this reduction in Hb level are not well understood, as it is well known that some medications may cause a decrease in Hb level (32), so the effect of BOTOX and HA injection needs further investigation.…”

Section: Discussionsupporting

confidence: 91%

“…Another study involving adult albino rats showed that BOTOX injections in the bones and bone marrow increased ALP. [24], while the present study showed a significant decrease in ALP in the group injected with BOTOX and HA filler. In line with our findings, an analysis performed in 2019 illustrated a reduction in the ALP level of mice injected with botulinum toxin (24).…”

Section: Discussioncontrasting

confidence: 43%

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Assessment of selected biochemical and immunological parameters after treatment by Cosmetic Procedures

2023

JPTCP

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Background: The use of non-invasive cosmetic procedures such as Botulinum toxin and hyaluronic acid filler (HA) are commonly used in cosmetic and therapeutic. However, BOTOX therapy is generally considered safe and without significant adverse effects. However, these treatments' impacts must be understood and investigated thoroughly. The objective of this prospective study was to evaluate the impact of using injections of hyaluronic acid filler (HA) and BOTOX on some human biochemical parameters, CBC, and inflammatory markers. Methods: Eighty-five subjects who have undergone BOTOX and/or HA injections were recruited. Samples of study and control groups were collected into EDTA for CBC and serum tubes for the analysis of the rest of the parameters. Results: Our results revealed that using BOTOX and HA filler has no significant effect on ALT, AST, GGT, and CK-MB levels (p-value > 0.05). While there was a decrease in ALP level in subjects injected with both BOTOX and HA filler. Moreover, we discovered that two of our study groups had significantly higher serum LDH levels than the control group. CRP, TNF-α, and IL-17 were elevated in the study group compared with the control group. However, this difference was statistically insignificant (p-value > 0.05). Conclusion: Accordingly, using BOTOX and HA filler may result in mild changes in clinical laboratory tests. Future investigations are now necessary to highlight the influence of these cosmetic procedures on various clinical laboratory parameters.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 43%

Assessment of selected biochemical and immunological parameters after treatment by Cosmetic Procedures

2023

JPTCP

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“…The biochemical analysis was validated using a Cobas 8000 C702 chemistry analyzer (Roche, Mannheim, Germany). Components including ALT, AST, BUN, creatinine, and calcium were detected as previously described [ 57 ].…”

Section: Methodsmentioning

confidence: 99%

Gamma Aminobutyric Acid-Enriched Fermented Oyster (Crassostrea gigas) Increases the Length of the Growth Plate on the Proximal Tibia Bone in Sprague-Dawley Rats

Lee

Hwangbo

et al. 2020

Molecules

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Bone growth during childhood and puberty determines an adult’s final stature. Although several prior studies have reported that fermented oyster (FO) consisting of a high amount of gamma aminobutyric acid can be attributed to bone health, there is no research on the efficacy of FO on growth regulation and the proximal tibial growth plate. Therefore, in this study, we investigated the effect of FO oral administration on hepatic and serum growth regulator levels and the development of the proximal tibial growth plate in young Sprague-Dawley rats. Both oral administration of FO (FO 100, 100 mg/kg FO and FO 200, 200 mg/kg FO) and subcutaneous injection of recombinant human growth hormone (rhGH, 200 μg/kg of rhGH) for two weeks showed no toxicity. Circulating levels of growth hormone (GH) significantly increased in the FO 200 group. The expression and secretion of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) were enhanced by FO administration. FO administration promoted the expression of bone morphogenic proteins IGF-1 and IGFBP-3 in the proximal tibial growth plate. This positive effect of FO resulted in incremental growth of the entire plate length by expanding the proliferating and hypertrophic zones in the proximal tibial growth plate. Collectively, our results suggested that oral administration of FO is beneficial for bone health, which may ultimately result in increased height.

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“…Until now, the biological phenotypes of Korl (Korl:ICR, C57BL/6NKorl, BALB/cKorl and DBA/2Korl) were compared with other substrains provided by commercial venders, to verify the stability of their characteristics. These phenotypes showed similar responses to various disease-inducing agents in cancer biology, neurobiology, immunology and microbiology [ 13 – 16 ]. As part of the current study, we investigated the influence of BALB/cKorl substrain background on DMBA+TPA induced skin carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

Influence of three BALB/c substrain backgrounds on the skin tumor induction efficacy to DMBA and TPA cotreatment

et al. 2020

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Differences in responsiveness of BALB/c substrains have been investigated in various fields, including diabetes induction, corpus callosum deficiency, virus-induced demyelinating disease, aggressive behavior and osteonecrosis. However, induction efficacy of skin tumor remains untried. We therefore investigated the influence of BALB/c substrain backgrounds on the skin tumor induction efficacy in response to DMBA (7,12-Dimethylbenz[a]anthracene) and TPA (12-O-tetradecanoylphorbol-13-acetate) cotreatment. Alterations in the levels of tumor growth related factors, histopathological structure, and the expression to tumor related proteins were measured in three BALB/c substrains (BALB/cKorl, BALB/cA and BALB/cB) after exposure to DMBA (25 μg/kg) and three different doses of TPA (2, 4 and 8 μg/kg). The average number and induction efficacy of tumors in response to DMBA+TPA treatment were significantly greater in the BALB/cKorl substrain than in BALB/cA and BALB/cB. However, cotreatment with DMBA+TPA induced similar responses for body and organ weights of all three substrains. Few differences were detected in the serum analyzing factors, while similar responsiveness was observed for blood analyzing factors after DMBA+TPA treatment. Furthermore, the three BALB/c substrains exhibited similar patterns in their histopathological structure in DMBA+TPA-induced tumors. The expression levels of apoptotic proteins and tumor related proteins were constantly maintained in all three BALB/c substrains treated with DMBA+TPA. In addition, the responsiveness to cisplatin treatment was overall very similar in the three BALB/c substrains with DMBA+TPA-induced tumors. Taken together, these results indicate that genetic background of the three BALB/c substrains does not have a major effect on the DMBA+TPA-induced skin carcinogenesis and therapeutic responsiveness of cisplatin, except induction efficacy.

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Comparison study of the response with botulinum toxin muscle injection in the ICR mice from three different sources

Cited by 6 publications

References 26 publications

Assessment of selected biochemical and immunological parameters after treatment by Cosmetic Procedures

Assessment of selected biochemical and immunological parameters after treatment by Cosmetic Procedures

Gamma Aminobutyric Acid-Enriched Fermented Oyster (Crassostrea gigas) Increases the Length of the Growth Plate on the Proximal Tibia Bone in Sprague-Dawley Rats

Influence of three BALB/c substrain backgrounds on the skin tumor induction efficacy to DMBA and TPA cotreatment

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