Comparisons of GFR estimation using the CKD Epidemiology Collaboration (CKD-EPI) equation and other creatinine-based equations in Asian population: a systematic review

Sudchada, Patcharaporn; Laehn, Spencer

doi:10.1007/s11255-016-1357-1

Cited by 22 publications

(15 citation statements)

References 19 publications

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“…Microalbuminuria was defined as urine ACR 2.5–25.0 mg/mmol in males and 3.5–25 in females, and macroalbuminuria defined as urine ACR 25.0 mg/mmol in both, as previously described (12) GFR was measured using the 99m Tc-DTPA renal dynamic imaging method (4). eGFR was calculated using two different equations: MDRD recalibrated for Chinese patients and CKD-EPI (4,19,20). MDRD equation was as follows: eGFR (ml/min/1.73 m 2 )=186x(SCRx0.011) −1.154 x(age) −0.203 x(0.742 if female/1 if male)x1.233, where SCR was in µmol/l and 1.233 was the adjusting coefficient for Chinese patients (12).…”

Section: Methodsmentioning

confidence: 99%

“…MDRD equation was as follows: eGFR (ml/min/1.73 m 2 )=186x(SCRx0.011) −1.154 x(age) −0.203 x(0.742 if female/1 if male)x1.233, where SCR was in µmol/l and 1.233 was the adjusting coefficient for Chinese patients (12). CKD-EPI equation was as follows: eGFR (ml/min/1.73 m 2 )=141 × min(SCR/k, 1 a ) × max(SCR/k, 1 −1.209 )x(0.993 age )x(1.018 if female/1 if male), where k is 0.7 for females and 0.9 for males, a is −0.329 for females and −0.411 for males (19,20). …”

Section: Methodsmentioning

confidence: 99%

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SUDOSCAN, an effective tool for screening chronic kidney disease in patients with type 2 diabetes

Mao

Liu

Qiao

et al. 2017

Experimental and Therapeutic Medicine

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SUDOSCAN is a non-invasive method of measuring peripheral small fiber and autonomic nerve activity by detection of abnormal sweat gland function through electrochemical skin conductance. It has been reported to be an effective screening tool in early detection of microvascular type 2 diabetes mellitus (T2DM) complications including diabetic neuropathy and nephropathy in recent studies. However, previous studies used estimated glomerular filtration rate (eGFR) as the golden standard, which has a 90% chance of being within 30% of the measured GFR at best. No relevant study has been performed in the Chinese population concerning SUDOSCAN in the screening of diabetic nephropathy (DN) in comparison with GFR. In this cross-sectional study, SUDOSCAN was performed in 176 Chinese patients with T2DM between September 2014 and September 2015. It was found that the SUDOSCAN test had a sensitivity of 57.8% and a specificity of 100% to detect chronic kidney disease at a cut-off SUDOSCAN-DN score of 59.5. The area under receiver operating characteristic curve for DN was 0.85 [95% confidence interval (CI), 0.76–0.93] compared with 0.84 for eGFRMDRD (MDRD, modification of diet in renal disease; 95% CI, 0.71–0.98) and 0.77 for eGFREPI (EPI, epidemiology collaboration; 95% CI, 0.68–0.87). Patients with DN score <59.5 had a significantly lower GFR level (P<0.001) and significantly older age (P<0.001), longer duration of T2DM (P<0.001) and higher risk of diabetic complications, including diabetic neuropathy (P<0.001) and peripheral vascular disease (P<0.05). These results suggested that SUDOSCAN may be useful for detecting patients at risk of impaired renal function as part of a screening program in the Chinese population with T2DM.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

SUDOSCAN, an effective tool for screening chronic kidney disease in patients with type 2 diabetes

Mao

Liu

Qiao

et al. 2017

Experimental and Therapeutic Medicine

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“…Second, patient mortality in this study was unaccounted for, therefore, the incidence of CKD may be underestimated. Third, eGFR was calculated using the CKD-EPI equation, which has been validated in Caucasian and African American populations; there are limited available data for people of Arab descent [ 47 ]. Finally, the changes in variables such as blood pressure and HbA1c, and the impact of nephroprotective medications such as ACE inhibitors and ARBs over time were not evaluated in this study.…”

Section: Discussionmentioning

confidence: 99%

Chronic kidney disease in patients at high risk of cardiovascular disease in the United Arab Emirates: A population-based study

2018

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Chronic kidney disease has become an increasingly significant clinical and public health issue, accounting for 1.1 million deaths worldwide. Information on the epidemiology of chronic kidney disease and associated risk factors is limited in the United Arab Emirates. Therefore, this study aimed to evaluate the incidence and causes of chronic kidney disease stages 3–5 in adult United Arab Emirates nationals with or at high risk of cardiovascular disease. This retrospective study included 491 adults with or at high risk of cardiovascular disease (diabetes mellitus or associated clinical disease) who attended outpatient clinics at a tertiary care hospital in Al-Ain, United Arab Emirates. Estimated glomerular filtration rate was assessed every 3 months from baseline to June 30, 2017. Chronic kidney disease stages 3–5 were defined as an estimated glomerular filtration rate < 60 mL/min/1.73 m2 for ≥ 3 months. Multivariable Cox's proportional hazards analysis was used to determine the independent risk factors associated with developing chronic kidney disease stages 3–5. The cumulative incidence of chronic kidney disease stages 3–5 over a 9-year period was 11.4% (95% confidence interval 8.6, 14.0). The incidence rate of these disease stages was 164.8 (95% confidence interval 121.6, 207.9) per 10,000 person-years. The independent risk factors for developing chronic kidney disease stages 3–5 were older age, history of coronary heart disease, history of diabetes mellitus, and history of smoking. These data may be useful to develop effective strategies to prevent chronic kidney disease development in high-risk United Arab Emirates nationals.

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“…including Asian (36), Japanese (37), Chinese (38), Pakistanis (39), and African (12). However, previous attempts to modify the CKD-EPI-Cr formula for Latin American populations (40) and Brazilian population (33) found no significant improvements of the modified versus the original formula.…”

Section: How To Better Evaluate Egfr In La Populationsmentioning

confidence: 99%

Performance of the CKD-EPI and MDRD equations to estimate the glomerular filtration rate: a systematic review of Latin American studies

Brañez-Condorena¹,

Goicochea-Lugo

Zafra-Tanaka

et al. 2020

Preprint

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BackgroundMost commonly used equations to estimate the glomerular filtration rate (GFR) are the CKD-Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD). However, it is not clear which one shows a better performance in Latin America. Objective To assess the performance of both estimated GFR (eGFR) equations in Latin American countries. Methods In January 2019, we performed a systematic search in PubMed, Scopus, and “Biblioteca Regional de Medicina” (BIREME) to identify studies that reported eGFR using CKD-EPI and MDRD equations and compared them with a measured GFR (mGFR) using exogenous filtration markers, among adults from Latin American countries. Study selection, data extraction, and risk of bias evaluation were performed by two reviewers independently. We performed meta-analyses of P30, bias (using mean difference [MD] and its 95% confidence intervals [95% CI]), sensitivity, and specificity; and evaluated certainty of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. Results We included 12 papers, six of them were meta-analyzed (5 from Brazil and 1 from Mexico). Meta-analyses that compared CKD-EPI using creatinine measured with calibration traceable to isotope dilution mass spectrometry (CKD-EPI-Cr IDMS) and MDRD-4 IDMS did not show statistically significant differences in bias (5 studies, MD: 0.55 mL/min/1.73m 2 , 95% CI: -3.34 to 4.44), P30 (2 studies, MD: 4%, 95% CI: -4% to 13%), sensitivity (2 studies, 76% and 75%), and specificity (2 studies, 91% and 89%), with very low certainty of evidence for bias and P30, and low certainty of evidence for sensitivity and specificity. Conclusions We found that the performance of CKD-EPI-Cr IDMS and MDRD-4 IDMS do not differ significantly, although CKD-EPI-Cr IDMS tends to have a non-significant better performance in terms of P30. However, since most of the meta-analyzed studies were from Brazil, results may not be extrapolated to other Latin American countries. Trial registration CRD42019123434, PROSPERO. Registered 18 February 2019.

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Comparisons of GFR estimation using the CKD Epidemiology Collaboration (CKD-EPI) equation and other creatinine-based equations in Asian population: a systematic review

Cited by 22 publications

References 19 publications

SUDOSCAN, an effective tool for screening chronic kidney disease in patients with type 2 diabetes

SUDOSCAN, an effective tool for screening chronic kidney disease in patients with type 2 diabetes

Chronic kidney disease in patients at high risk of cardiovascular disease in the United Arab Emirates: A population-based study

Performance of the CKD-EPI and MDRD equations to estimate the glomerular filtration rate: a systematic review of Latin American studies

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