Comparisons on enhancing the immunity of fresh and dry Cordyceps militaris in vivo and in vitro

Cordyceps Militaris Alleviates Severity of Murine Acute Lung Injury Through miRNAs-Mediated CXCR2 Inhibition

“…CM has been used as a natural invigorant for longevity, endurance, and vitality for thousands of years in China. More and more components in CM have been identified to have thearapeutic effects on various diseases, including cancer [20,21,24,25]. For example, Cordycepin (3'-deoxyadenosine) is a nucleoside derivative that has been purified from CM.…”

“…Some purified extracts from CM has recently shown to have beneficial effects on various diseases, possibly through adjust immunity [20,21]. Recently, effects of CM in inhibiting carcinogenesis in several types of malignant tumors have been reported, and these effects have been proposed to be conducted through reducing cancer metastatic potential and enhancing cytokine induction.…”

Solid state fermentation with Cordyceps militaris SN-18 enhanced antioxidant capacity and DNA damage protective effect of oats (Avena sativa L.)

“…C. militaris has received considerable attention in recent years due to the recognition that it has biological effects with healthstimulating properties and medicinal effects. A wide range of bioactive components in C. militaris such as cordycepin, cordyceps polysaccharide, cordycepic acid, fibrinolytic enzyme, and superoxide dismutase have been reported to possess various biological properties, including antivirus, blood pressure reduction, anticancer, antiaging, hypoglycemic, antineoplastic and inhibition of inflammation (Cui et al, 2008;Das, Masuda, Sakurai, & Sakakibara, 2010;Kim et al, 2014;Wang et al, 2012;Zhu et al, 2013). Because of its attractive beneficial effects and rarity in nature, C. militaris is considered as one of the most expensive mushrooms in China (Xiao et al, 2014), and C. militaris cultivation technologies have been receiving great interest in recent years.…”

Immune activation and toxicity evaluation of freshCordyceps militarisextracts by high-pressure processing

“…The CMP was isolated according to the method used by Zhu et al (2013) with minor modifications. HFCM (100 g) and UFCM (100 g) were defatted with 1000 ml ether, respectively, and then stirred with 1000 ml aqueous (80% alcohol) for 24 h. The mixes were filtrated, and the residues were ultrasound-assisted extracted twice for 2 h with 500 ml water at room temperature, and the combined filtrates were concentrated to a final volume of approximately 100 ml.…”

“…Among those biological actions, immune response plays an important role in protecting the body against the diseases (Shin et al, 2010). Our previous studies showed the fresh C. militaris extracts (FCM) was stronger than dry C. militaris extracts (DCM) on enhancing immune activation (Zhu, Pan, Liang, Wu, & Yang, 2013), indicating that FCM is an excellent health food resource in treating immunodeficiency diseases.…”