Compatibility studies with pharmaceutical excipients for aripiprazole–heptakis (2,6-di-O-methyl)-β-cyclodextrin supramolecular adduct

Encapsulation of Risperidone by Methylated β-Cyclodextrins: Physicochemical and Molecular Modeling Studies

“…The thermal profile of DM-β-CD ( Figure 6b) is relatively simplistic and reveals a good thermal stability of this cyclodextrin up to 232 • C, when the decomposition process begins, showing DTG peaks at 343 and 353 • C, respectively. The HF curve of DM-β-CD shows exothermic effects at 252, 286 and 360 • C attributed to the thermooxidation processes of CD, its melting being probably accompanied and overlapped with these thermooxidations [11,36]. At 500 • C, the solid char has a residual mass 6.73%, so that the degradation of this functionalized polysaccharide is almost complete at this temperature.…”

“…The FTIR spectrum of DM-β-CD reveals a broad absorption band in the spectral region of 3500-3300 cm −1 assigned to O-H stretching vibration of non-methylated hydroxyl moieties and a large region below 1500 cm −1 which displays distinct peaks, characteristic to the cyclodextrin ring [11,36,39].…”

“…RSP solubility in the inclusion complexes obtained using the kneading method was assessed by means of the shake-flask method [10,11,41]. The RSP concentration in the saturated solution was evaluated using UV spectrophotometric measurements.…”

“…Molecular encapsulation of bioactive compounds in the CDs has achieved pharmaceutical relevance since the physical, chemical and biopharmaceutical characteristics of guest molecules are remarkably improved. CD inclusion complexes can increase the solubility of insoluble drug molecules and the antioxidant properties, can improve the chemical stability, the biological activity and the bioavailability of guest substances, may reduce/eliminate the unpleasant smell and taste, may prevent drug-excipient or drug-drug interactions [6][7][8][9][10][11][12][13][14][15]. β-cyclodextrin (β-CD) is the most frequently used in the pharmaceutical field due to its availability, appropriate internal cavity size for an important number of drug substances and economic advantages.…”

Risperidone/Randomly Methylated β-Cyclodextrin Inclusion Complex—Compatibility Study with Pharmaceutical Excipients

“…This particular structure of CDs confers them multiple applications in the pharmaceutical field, food, cosmetics, textile, and chemistry industry based on their property of forming guest–host inclusion complexes [ 6 , 7 , 8 , 9 , 10 ]. The inclusion complexation leads to an increase in the solubility of insoluble drug substances, including the antiviral drug remdesivir [ 11 ] to improve the chemical stability, the biological activity, and the bioavailability of guest molecules, to prevent drug–excipient or drug–drug interactions, to reduce/eliminate the unpleasant taste or odors and also ocular and gastrointestinal irritation [ 10 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. Therefore, the encapsulation of the drug in the CD cavity results in a remarkable improvement of physicochemical, biopharmaceutical properties, and therapeutic potential of the guest [ 23 , 24 , 25 ].…”