Comperative phyto toxicological and anti inflammatory effects of leaves extracts of holoptelea integrifolia

Abstract

Objective: Plants play valuable role in the new drug discovery and significantly used to treat different diseases. Nowadays scientists are investigating the therapeutically active phytochemical constituents that are safe and producing lesser side effect in comparative to other standard drugs.Methods: The plant Holoptelea integrifolia is medicinally important and this study was carried out to evaluate the anti inflammatory activity of aqueous extract of the leaves of Holoptelea integrifolia in male albino rats wistar stain treated with acetic acid to induced paw edema.Results: Result indicated the significant anti-inflammatory activity while compared with standard drug (diclofenac sodium).Brine shrimp bioassay (cytotoxicity), phytotoxicity, insecticidal and enzyme inhibition activity was performed in different extracts of the leaves of H. integrifolia. Results of brime shrimp bioassay indicating positive lethality at high dose in BuOH and H2O only. While the results of phytotoxicity in all crude extracts displayed mild phytotoxicity(46.3 µg/ml) in high concentrations (1000 µg/ml) except H2O extract showed no phytotoxicity. Result of insecticidal activity revealed that BuOH extract were found more effective against Rhyzoperthadominica, the EtOH extract expressed major while EtOAC extract showed mild activity against Callosobruchusanalis. Aqueous extract possessed no insecticidal activity.Conclusion: Results of Urease inhibition activity suggested that EtOAC and BuOH extracts of this plant expressed no activity while EtOH and H2O possessed mild inhibiting activity.Bangladesh Journal of Medical Science Vol.17(2) 2018 p.212-217

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“…After that the paw volume were measured at 1, 2, 3, 4, 5 and 6 hours representing final paw volume (Vf). Percentage inhibition of paw volume (as given formula) was calculated by Newbould method (Yasin et al, 2018, Newbould, 1963.…”

“…According to world health organization (WHO) guidelines inflammation is considered to be major cause for various chronic diseases (Khansari et al, 2009, Organization, 2015. A number of antiinflammatory drugs recommended in the treatment of rheumatoid arthritis, bone marrow depression, tuberculosis, edema, gastric intolerance and inflammation (Yasin et al, 2018, Maitra et al, 2016, Khalid et al, 2013, Okokon and Nwafor, 2010. Recently, nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently employed for the prevention and treatment of inflammation.…”

A Cross-Sectional Analysis of Knowledge, Beliefs and Practices Regarding Traditional Medicine Use among Pharmacy Students of Different Private and Government Universities of Lahore, Pakistan

“…Amongst the students accustomed to the use of traditional medicine, a great deal agreed with its usefulness in the treatment and cure of diseases. A total of 93.3% (n=237) approved its benefits that subsequently attained in a diseased condition and the literature supports this through traditional medicine excessive use over various regions all around the globe [18][19][20] . Pupils were questioned for their perceptions about the safety and any concerns pertaining to side effects of the traditional medicine.…”

Antibacterial Effect of Some Palestinian Plant Extracts against Clinical Multidrug-Resistant Gram- Negative Bacteria: A possible synergism with antibiotics

“…These chemical components exert their antimicrobial activity on bacteria through the disruption of bacterial membrane integrity. Another important characteristic of essential oils is their hydrophobicity which enables them to penetrate lipid components of bacterial cell membrane and mitochondria, disrupting the cell structure and rendering them more permeable resulting in leakages of critical molecules from within the cell and eventual death of the bacteria cells 48,49,50…”