Complementary and alternative healthcare use by participants in the PACE trial of treatments for chronic fatigue syndrome

Lewith, George; Stuart, Beth; Chalder, Trudie; McDermott, Clare; White, Peter

doi:10.1016/j.jpsychores.2016.06.005

Cited by 7 publications

(7 citation statements)

References 20 publications

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“…The third advantage of the current study is exclusion of patients who use medication, with the exception of oral contraceptives and paracetamol. CFS/ME patients frequently use a significant amount of medication, in a recent study 64% of patients used complementary and alternative medicine [ 60 ]. Another study found that > 90% of CFS/ME patients use at least one drug or supplement, especially antidepressants, sedatives and muscle relaxants [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Cytokine signatures in chronic fatigue syndrome patients: a Case Control Study and the effect of anakinra treatment

et al. 2017

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BackgroundCytokine disturbances have been suggested to be associated with the Chronic Fatigue Syndrome/Myalgic encephalomyelitis (CFS/ME) for decades.MethodsFifty female CFS patients were included in a study on the effect of the interleukin-1-receptor antagonist anakinra or placebo during 4 weeks. EDTA plasma was collected from patients before and directly after treatment. At baseline, plasma samples were collected at the same time from 48 healthy, age-matched female neighborhood controls. A panel of 92 inflammatory markers was determined in parallel in 1 μL samples using a ‘proximity extension assay’ (PEA) based immunoassay. Since Transforming growth factor beta (TGF-β) and interleukin-1 receptor antagonist (IL-1Ra) were not included in this platform, these cytokines were measured with ELISA.ResultsIn CFS/ME patients, the ‘normalized protein expression’ value of IL-12p40 and CSF-1 was significantly higher (p value 0.0042 and 0.049, respectively). Furthermore, using LASSO regression, a combination of 47 markers yielded a prediction model with a corrected AUC of 0.73. After correction for multiple testing, anakinra had no effect on circulating cytokines. TGF-β did not differ between patients and controls.ConclusionsIn conclusion, this study demonstrated increased IL-12p40 and CSF-1 concentrations in CFS/ME patients in addition to a set of predictive biomarkers. There was no effect of anakinra on circulating cytokines other than IL-1Ra. Trial Registration: ClinicalTrials.gov Identifier: NCT02108210, Registered April 2014Electronic supplementary materialThe online version of this article (10.1186/s12967-017-1371-9) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Cytokine signatures in chronic fatigue syndrome patients: a Case Control Study and the effect of anakinra treatment

et al. 2017

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“…In 2007, the total annual expenditure on CAM services in the United States was 34 billion USD -a 25% increase compared to 1997 [10]. In 2016, the reported yearly out-of-pocket spending on CAM services in the United States reached 58.5 billion USD [11,12].…”

Section: Introductionmentioning

confidence: 99%

The scope of complementary and alternative medicine in Poland

Perdyan

Wasiukiewicz

Szastok

et al. 2021

Nowotwory. Journal of Oncology

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Introduction.Complementary and alternative medicine (CAM) is widely used by patients. The most frequent CAM users are patients with cancer, but patients with other chronic diseases also utilize these methods. Materials and methods. Data on the use of CAM were obtained from Google searches. For each specific search term, the first three Google pages were analyzed.Results. The analysis included 91 CAM institutions matching the inclusion criteria. The most common anticancer services were intravenous vitamin C infusion, saltwater, intravenous infusion of glutathione, colon irrigation, an anticancer diet, bio-resonance, and intravenous ozone infusions. The most common non-cancer entities treated were rheumatic diseases, chronic fatigue syndrome, arterial hypertension, allergies, borreliosis, diabetes, atherosclerosis, and depression. Anticancer therapies were more expensive than those used for non-malignant diseases (medians 250 PLN and 170 PLN, respectively; p = 0.041). Conclusions. This study provides a comprehensive overview of CAM methods used in Poland. These data may facilitate social education and the development of preventive measures.

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Section: Introductionmentioning

confidence: 99%

“…11 About 70% of the CFS population use at least one type of CAM therapy; of these modalities, herbal therapy, meditation, relaxation, homeopathy, acupuncture, massage therapy, and naturopathy are the most commonly used. 12 Traditionally known as the "King of Herbs," ginseng is an important perennial herb derived from the family Araliaceae and the genus Panax. 13 Ginsenosides are known to have biological activity in maintaining homeostasis of the body and enhancing vital energy.…”

Section: Introductionmentioning

confidence: 99%

Ginseng for the Treatment of Chronic Fatigue Syndrome: A Systematic Review of Clinical Studies

Yang

Shin

Dabrh

et al. 2022

Glob Adv Health Med

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Background Chronic fatigue syndrome (CFS) is a complex and often disabling chronic condition emerging worldwide, with no curative or definitive therapy yet identified. Ginseng has been widely used to treat fatigue in other patient groups and conditions; however, a systematic review focusing solely on the impact of ginseng on fatigue in patients with CFS has not been performed. Objective This study aimed to assess the current state of evidence regarding ginseng for CFS. Methods Multiple databases were searched from inception to October 2020. All data was extracted independently and in duplicates. Outcomes of interest included the effectiveness and safety of ginseng in patients with CFS. Results 2 studies enrolling 68 patients were deemed eligible, including one randomized clinical trial and one prospective observational study. The certainty of evidence in the effectiveness outcome was low and moderate from both studies, while the safety evidence was very low as reported from one study. Conclusion Study findings highlight a potential benefit of ginseng therapy in the treatment of CFS. However, we are not able to draw firm conclusions due to limited clinical studies. The paucity of data warrants limited confidence. There is a need for future rigorous studies to provide further evidence.

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Complementary and alternative healthcare use by participants in the PACE trial of treatments for chronic fatigue syndrome

Abstract: Background

Cited by 7 publications

References 20 publications

Cytokine signatures in chronic fatigue syndrome patients: a Case Control Study and the effect of anakinra treatment

Cytokine signatures in chronic fatigue syndrome patients: a Case Control Study and the effect of anakinra treatment

The scope of complementary and alternative medicine in Poland

Ginseng for the Treatment of Chronic Fatigue Syndrome: A Systematic Review of Clinical Studies

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