Complementary and alternative therapies in the treatment of chronic hepatitis C: a systematic review

Coon, J Thompson; Ernst, Edzard

doi:10.1016/j.jhep.2003.11.014

Cited by 66 publications

(47 citation statements)

References 34 publications

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“…Perceived benefits from herbal medicine therapy include more energy and reduction in fatigue, as well as positive effects on the immune system [28].…”

Section: Discussionmentioning

confidence: 99%

Food Supplement for Therapy of HCV

Younes¹

2013

J Antivir Antiretrovir

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Hepatitis C is a progressing global health problem. The expense of the exciting regimen for treatment is not available for many patients. Herbal medicines have been used as complementary therapy in the treatment of liver diseases for a long time. Fifty one patients with hepatitis C have been seen in our outpatient clinic, with twelve patients as control. Patients were interviewed to obtain detailed clinical data before and after treatment. The herbal medicines used in the treatment of HCV are Milk Thistle, Phyllanthus, Garlic, Cinnamon, Parsley, Black seed and AKHY-J-25 (mixture of herbs). Every patient received single oral capsule of herbal preparations powder, in early morning on an empty stomach with two cups of water and simple breakfast after two hours, from three months to two years, and twelve patients as control received placebo. The results showed 20% of patients had no detectable HCV RNA in serum at 24 week treatment, 72.6% showed clinical and biochemical improvement with decline of HCV RNA to lower limit and 7.4% showed clinical and biochemical improvement without change in level of HCV RNA.

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“…Perceived benefits from herbal medicine therapy include more energy and reduction in fatigue, as well as positive effects on the immune system [28].…”

Section: Discussionmentioning

confidence: 99%

Food Supplement for Therapy of HCV

Younes¹

2013

J Antivir Antiretrovir

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“…There have been several randomized clinical trials of traditional Chinese medicine in the treatment of hepatitis C, however, the methodological quality of these studies is generally considered poor [63][64][65][66][67][68][69][70] . In two trials of herbal formulations in combination with interferon-alfa, there was a trend toward greater clearance of HCV RNA and ALT normalization with the combination treatment compared with patients receiving monotherapy [63,64] .…”

Section: Traditional Chinese Herbal Medicationsmentioning

confidence: 99%

Complementary and alternative medications in hepatitis C infection

Marzio¹,

Fenkel²

2014

WJH

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Chronic hepatitis C (CHC) infection affects almost 3% of the global population and can lead to cirrhosis, liver failure, and hepatocellular carcinoma in a significant number of those infected. Until recently, the only treatments available were pegylated interferon and ribavirin, which traditionally were not very effective and have considerable side effects. For this reason, interest in complementary and alternative medications (CAM) in the management of hepatitis C has been investigated. Some CAM has demonstrated therapeutic potential in chronic hepatitis C treatment. Unfortunately, some CAM has been shown to have the potential to cause drug-induced liver injury. This article will review and evaluate many of the natural molecules that interact with the hepatitis C virus (HC�) life cycle and discuss hepatitis C virus (HC�) life cycle and discuss virus (HC�) life cycle and discuss their potential use and safety in HC� therapy, as well as highlight some important interactions between medical and complementary treatments. Key words: Hepatitis C infection; Natural molecules; Direct acting antivirals; Hepatotoxicity; Herbal treatments Core tip: Over the last 10 years there has been a substantial increase in reports of natural compounds displaying anti-viral activity against hepatitis C. At this time, there is no firm evidence supporting complementary and alternative medications for hepatitis C virus infection.hepatitis C virus infection. virus infection. Due to a limited number of trials and small numbers of subjects included in them, it is not possible to fully evaluate the risk of adverse events connected with the use of these products.Halegoua-De Marzio DL, Fenkel JM. �omplementary and al�omplementary and alternative medications in hepatitis � infection.

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“…Also, the main focus of most of the modern medicine researches conducted on camel milk effects is on the liver. Recent findings have shown antiviral effects of natural materials, such as CM against the hepatitis C virus (7). Special bioactives along with camel immune system and its transfer Copyright to milk causes the milk to have pharmacological effects in favor of the liver, including protective effects against viral and bacterial agents, chemical, and toxic substances.…”

Section: Introductionmentioning

confidence: 99%