Complementary medicine and phospholipase A2 receptor (PLA2R)–related membranous nephropathy—fortuitous or causal?

Kaur, Prabhjot; Prabhahar, Arun; Kumar, Ashwani; Pal, Devendra; Kumar, Vinod; Sekar, Aravind; Jha, Vivekanand; Nada, Ritambhra; Sethi, Jasmine; Divyaveer, Smita; Rathi, Manish; Kohli, Harbir Singh; Ramachandran, Raja

doi:10.1016/j.kint.2022.11.008

Cited by 3 publications

(2 citation statements)

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“… 7 Although all patients in the present study underwent a reasonable malignancy screening, none showed any signs of cancer. In an interesting finding, CAM consumption was associated with both PLA2R-related 8 and NELL1-related MN. 2 , 4 Kurien et al.…”

Section: Discussionmentioning

confidence: 87%

Clinical Characteristics and Outcomes of Neural Epidermal Growth Factor-like 1 Protein-Associated Membranous Nephropathy

Narayanasami,

Vijayakumar,

Trivedi

et al. 2024

Kidney International Reports

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Section: Discussionmentioning

confidence: 87%

Clinical Characteristics and Outcomes of Neural Epidermal Growth Factor-like 1 Protein-Associated Membranous Nephropathy

Narayanasami,

Vijayakumar,

Trivedi

et al. 2024

Kidney International Reports

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“…They include identification of high-risk genetic loci in MN,[ 16 ] identification of M-type phospholipase A2 receptor (PLA2R) as being important to MN pathogenesis, a marker of disease activity, and a therapeutic target, and complementary and alternative medicine-related MN. [ 17 18 19 20 21 ] Glomerular Research And Clinical Experiments-IgA Nephropathy in Indian}s (GRACE-IGAI)[ 22 ] and other studies[ 23 24 ] from India showed an overabundance of chronic lesions and lack of features indicating active disease in the kidney biopsy in IgAN. Arivazhagan et al .…”

Section: Introductionmentioning

confidence: 99%

Indian TrANslational GlomerulonephrItis BioLogy nEtwork (I-TANGIBLE): Design and Methods

Yadav

Ramachandran

Kumar

et al. 2023

Indian Journal of Nephrology

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Background and Aim: Primary glomerular disease accounts for one-sixth of all chronic kidney diseases (CKDs) in India. We remain limited in our ability to effectively treat these conditions because of lack of understanding of the disease mechanisms and lack of predictors to identify the clinical course and therapeutic responsiveness. We propose to develop a network of investigators in glomerular diseases, collect information in a systematic fashion to understand the clinical outcomes, answer translational research questions better, and identify and recruit patients for clinical trials. Materials and Methods: This is a prospective, observational study. The Indian TrANslational GlomerulonephrItis BioLogy nEtwork (I-TANGIBLE) cohort will enroll patients (>18 years) with biopsy-proven minimal change disease (MCD), focal segmental glomerulonephritis (FSGS), membranous nephropathy (MN), IgA nephropathy (IgAN), or membranoproliferative glomerulonephritis (MPGN) (immune complex- and complement-mediated), with first biopsy taken within 2 years of enrollment. Patients with estimated glomerular filtration (eGFR) rate <15 ml/min/1.73 m2 for >3 months at the time of screening, kidney transplant or bone marrow transplant recipients, patients with active malignancy, and patients with active hepatitis B/C replication or human immunodeficiency virus (HIV)-I/II will be excluded. Clinical details including history, medication history and details, and family history will be obtained. Consenting patient’s blood and urine samples will be collected and stored, aligned to their clinical follow-up. Expected Outcomes: The network will allow accurate ascertainment of disease burden of glomerular diseases across study sites, establishment of the treatment pattern of common glomerular diseases, investigation of medium- and long-term outcomes (remission, relapse, rate of eGFR decline), and building a suitable infrastructure to carry out clinical trials in primary glomerular disease.

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Caza

Jansi²,

Walker

et al. 2023

Kidney International

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Complementary medicine and phospholipase A2 receptor (PLA2R)–related membranous nephropathy—fortuitous or causal?

Cited by 3 publications

References 3 publications

Clinical Characteristics and Outcomes of Neural Epidermal Growth Factor-like 1 Protein-Associated Membranous Nephropathy

Clinical Characteristics and Outcomes of Neural Epidermal Growth Factor-like 1 Protein-Associated Membranous Nephropathy

Indian TrANslational GlomerulonephrItis BioLogy nEtwork (I-TANGIBLE): Design and Methods

The authors reply

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