Psoriasis is a chronic papulosquamous dermatosis with recurrent episodes of remission and relapse. Current available therapies are successful in managing clinical features at initial phases indeed; later found difficult in long term due to disruption of other systems. In Ayurveda, skin disorders are categorized on the basis of their doshic imbalance and aim to correct the same to cure the pathological condition by the intervention of dietary restrictions and medicines. In the presented study, we discuss two cases of psoriasis; one 23 years old male patient treated with cow urine distillate (CUD) and other 72 years old male with CUD after therapeutic purgation (Virechana). Dietary restriction of milk products was advised during the treatment period. Both cases showed significant clinical improvement which were assessed on the basis of Psoriasis Area Severity Index (PASI). The management was done for short duration of 2 months and requires more follow ups for the strong conclusion about the therapy options. The alone use of CUD for treating psoriasis is not yet tested and hence the presented case reports seem to be unique after the use of the same. It would direct the futuristic clinical studies to strengthen the hypothesis of clinical efficacy of CUD in aforesaid condition.