Complementary therapy for atopic dermatitis and other allergic skin diseases: facts and controversies

Boneberger, Susanne; Rupec, Rudolf A.; Ruzicka, Thomas

doi:10.1016/j.clindermatol.2009.03.017

Cited by 66 publications

(48 citation statements)

References 60 publications

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“…Previous studies have shown indigo and indirubin to be the main effective components of three species [13][14][15][16][17][18][19], but our research showed large differences in the concentrations of indigo and indirubin among these species. They have similar pharmacological activity, so this may be because of the differences in testing samples.…”

Section: Chemical Composition Analysiscontrasting

confidence: 47%

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Identification of three species commonly known as “daqingye” by internal leaf anatomy and high-performance liquid chromatography analyses

et al. 2018

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The macroscopic and microscopic morphologies and indigo and indirubin concentration of the traditional Chinese medicine herbs Isatis indigotica Fort., Polygonum tinctorium Ait., and Baphicacanthus cusia (Nees) Bremek, all commonly known as "daqingye", were determined and compared. The morphological analyses indicated that I. indigotica has leaves with winged petioles and no glandular hairs or crystals, P. tinctorium has leaves with membranous ocrea and clusters of calcium oxalate, and B. cusia has palisade cells in the mesophyll running over the main vein and single cells containing calcium carbonate crystals. Indigo and indirubin are chemical constituents that have been previously isolated from daqingye and were selected in this study as identification markers for high-performance liquid chromatography analysis due to their pharmacological activities. The chromatographic results showed that indigo and indirubin concentration varied significantly among the three species: high concentration of both indigo and indirubin were observed in I. indigotica, the highest concentration among the three daqingye plants was found in P. tinctorium but with low levels of indirubin, and the concentration of indigo and indirubin was quite low in B. cusia. In summary, three different species commonly known as daqingye were accurately distinguished by morphological observation, internal leaf anatomy analysis, and chromatographic analysis.

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Section: Chemical Composition Analysiscontrasting

confidence: 47%

“…1). Reports have indicated that indigo naturalis, prepared from leaves of plants such as B. cusia, P. tinctorium, and I. indigotica, has long been used to treat various inflammatory disease and dermatosis [19,20]. Indirubin, extracted from traditional herbal medicine, possesses anticancer, antileukemia effects [21,22].…”

Section: Digital Signaturementioning

confidence: 99%

Identification of three species commonly known as “daqingye” by internal leaf anatomy and high-performance liquid chromatography analyses

et al. 2018

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“…(puntos específicos: Xuehai, Quchi y Zhubin); la moxibustión sobre el sitio de la lesión, una vez al día por una semana. Después de dos semanas de finalizado el tratamiento se observó un 45% de curación en el sitio de la lesión (48).…”

Section: Los Niveles De Células Cd11bunclassified

Acupuntura en dermatitis atópica y mecanismos neuroinmumonológicos. Actualización

2011

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Atopic dermatitis isa high-prevalencediseasein our countryand the rest of the world. Its etiopathology is complex and multifactorial involving genetic, environmental and immunological factors. Many therapeutic options have been developed for its management. In recent years an increase in the use of acupunctureby patients with skin diseases, including atopic dermatitis, has been documented. Neuro-immunological studies have been conducted to explain the possible underlying mechanisms involved in the effect of this treatment.This articlepresentsa review ofthe most important aspectsof this issue.Key words: acupuncture, dermatitis atopic, physiopathology, immunomodulation. Acupuntura na dermatite atópica e mecanismos neuroinmumonológicos. AtualizaçãoResumo A dermatite atópica é uma doença de alta prevalência em nosso país eo resto do mundo. Sua etiopatogênese é complexa e multifatorial e envolve fatores genéticos, ambientais e imunológicos. Têm sido levantadas muitas opções de tratamento para a sua abordagem e nos últimos anos têm visto um aumento no uso da acupuntura como uma opção para pacientes que procuram com doenças de pele, incluindo dermatite atópica. Estudos de nível Neuroimmunological têm sido realizados para explicar os possíveis mecanismos subjacentes envolvidos no efeito deste tratamento. Este artigo apresenta uma revisão dos aspectos mais importantes desta entidade. Palabras ResumenLa dermatitis atópica es una patología de alta prevalencia tanto en nuestro medio como en el resto del mundo. Su etiopatogenia es compleja y multifactorial e involucra factores genéticos, ambientales e inmunológicos. Se han planteado múltiples opciones terapéuticas para su manejo y en años recientes se ha observado un incremento en el uso de la acupuntura como una opción que buscan los pacientes con patologías dermatológicas, en particular la dermatitis atópica. Estudios a nivel neuroinmunológico se han llevado a cabo para explicar los posibles mecanismos subyacentes involucrados en el efecto de este tratamiento. En este artículo se presenta una revisión sobre los aspectos más relevantes de esta entidad.Palabras clave: acupuntura, dermatitis atópica, fisiopatología, inmunomodulación.

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“…Indigo naturalis (also known as Qing Dai in Chinese), prepared from leaves of plants such as Baphicacavthus cusia, Polygonum tinctorium, Isatis indigotica and Indigofera tinctoria, has long been used to treat various inflammatory disease and dermatosis [4,5]. Our previous clinical studies found that topical indigo naturalis ointment was a safe and effective therapy for plaque-type psoriasis [6,7].…”

Section: Introductionmentioning

confidence: 98%

Indirubin, an acting component of indigo naturalis, inhibits EGFR activation and EGF-induced CDC25B gene expression in epidermal keratinocytes

Hsieh¹,

Lin²,

Tsai³

et al. 2012

Journal of Dermatological Science

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Complementary therapy for atopic dermatitis and other allergic skin diseases: facts and controversies

Cited by 66 publications

References 60 publications

Identification of three species commonly known as “daqingye” by internal leaf anatomy and high-performance liquid chromatography analyses

Identification of three species commonly known as “daqingye” by internal leaf anatomy and high-performance liquid chromatography analyses

Acupuntura en dermatitis atópica y mecanismos neuroinmumonológicos. Actualización

Indirubin, an acting component of indigo naturalis, inhibits EGFR activation and EGF-induced CDC25B gene expression in epidermal keratinocytes

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