Complete DNA sequence of canine adenovirus type 1.

Morrison, Mark; Onions, David; Nicolson, Lesley

doi:10.1099/0022-1317-78-4-873

Cited by 44 publications

(43 citation statements)

References 20 publications

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“…Finally, we wished to evaluate the hepatotropism of Ad5Luc1-CK1, since CAV-1 has been reported to rarely cause hepatitis in dogs. 32 Importantly, our data showed that liver transduction of Ad5Luc1-CK1 was significantly lower compared to Ad5Luc1.…”

Section: Novel Expanded Tropism For Cancer Gene Therapy Ma Stoff-khalmentioning

confidence: 68%

“…In this regard, there are two canine isolates, serotypes 1 and 2, which may offer novel adenovirus infection pathways. 32 CAV-2 is one of the few non-human adenoviruses that have been investigated as a gene transfer vector for human applications. Particularly, a replicationdeficient CAV-2 vector has been constructed 14,16,33 and displayed a distinct tropism not exhibited by human Novel…”

Section: Discussionmentioning

confidence: 99%

“…32 The following primers were applied: (forward) 5 0 -TATGGACTGGAC CTGATCCAAACGTT-3 0 and (reverse) 5 0 -TTTATCATTG ATTTTCCCCCACATAGGTGAAGG-3' (the stop codon TGA and the poly-adenylation signal TAAA are underlined). The plasmid pSHAFT is a cloning vector, which contains the Ad5 fiber gene with the knob region deleted and replaced by a small linker containing SmaI and EcoICRI restriction sites.…”

Section: Plasmid Constructionmentioning

confidence: 99%

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A human adenoviral vector with a chimeric fiber from canine adenovirus type 1 results in novel expanded tropism for cancer gene therapy

et al. 2005

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Section: Novel Expanded Tropism For Cancer Gene Therapy Ma Stoff-khalmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Plasmid Constructionmentioning

confidence: 99%

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A human adenoviral vector with a chimeric fiber from canine adenovirus type 1 results in novel expanded tropism for cancer gene therapy

et al. 2005

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“…In addition, another region needed to be amplified to obtain a phylogenetic tree confirming it. The gene regions (E1, E2, E3 and E4) of CAV-2 are responsible for efficient replication of the virus, viral gene expression and regulation of host-cell functions (MORRISON et al, 1997). Nine different amino acids have been identified on the molecular level (amino acid differences) between the China-Turkey isolates subgroup and the America-Europe subgroup strains.…”

Section: Discussionmentioning

confidence: 99%

Detection and molecular characterization of canine adenovirus type 2 (CAV-2) in dogs with respiratory tract symptoms in shelters in Turkey

2018

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Canine adenoviruses are agents responsible for two different infections in Canidae. While canine adenovirus type 1 (CAV-1) causes contagious hepatitis (HCC) in dogs, canine adenovirus type 2 (CAV-2) is responsible for infectious laryngotracheitis (ILT). CAV-2, especially in the respiratory tract, leads to an infection that can result in death in young and cohabitant animals. In public housing such as shelters, in addition to opportunistic infections, a disorder defined as canine infectious respiratory disease (CIRD) may also occur frequently. In this study, 155 nasal swabs were collected from dogs in two shelters where cases of respiratory system infections were closely monitored. These samples were tested for CAV-2 using polymerase chain reaction (PCR) with primers designed for the CAV E3 (Early) gene. Positive amplicons were subjected to DNA sequencing. CAV-2 nucleic acids were present in 2.5% (4/155) of the test samples. The phylogenetic assessment of the amplicon sequences revealed a 97.7%-98.9% similarity in the local viruses. The partial sequence analyses of the E3 gene of CAV-2 showed that Turkish and Chinese strains have differences in 9 amino acids. These differences redounded on phylogenetic analyses, and the virus which was considered as a single group, is now subdivided into two subgroups. One subgroup comprises American-European isolates and the other one consists of Turkish and Chinese isolates, so this subdivision can be classified into at least two subgroups, designated China-Turkey and America-Europe. To our knowledge, this is the first study that has examined the possible role of CAV-2 in respiratory system infections in dogs in Turkey, to provide novel and updated information regarding CAV-2.

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“…CAV-1 and CAV-2 were found to be genetically different by restriction endonuclease analysis [10,75] and by DNA hybridization [106]. The complete sequence analysis of both the CAV-1 and CAV-2 genome has revealed about 75% nucleotide identity [49,114]. Although CAV-1 and CAV-2 are related genetically and antigenically [109,168], they have different tissue tropism.…”

Section: Canine Adenovirus Typementioning

confidence: 99%

Canine respiratory viruses

2007

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-Acute contagious respiratory disease (kennel cough) is commonly described in dogs worldwide. The disease appears to be multifactorial and a number of viral and bacterial pathogens have been reported as potential aetiological agents, including canine parainfluenza virus, canine adenovirus and Bordetella bronchiseptica, as well as mycoplasmas, Streptococcus equi subsp. zooepidemicus, canine herpesvirus and reovirus-1,-2 and -3. Enhancement of pathogenicity by multiple infections can result in more severe clinical forms. In addition, acute respiratory diseases associated with infection by influenza A virus, and group I and II coronaviruses, have been described recently in dogs. Host species shifts and tropism changes are likely responsible for the onset of these new pathogens. The importance of the viral agents in the kennel cough complex is discussed.

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Complete DNA sequence of canine adenovirus type 1.

Cited by 44 publications

References 20 publications

A human adenoviral vector with a chimeric fiber from canine adenovirus type 1 results in novel expanded tropism for cancer gene therapy

A human adenoviral vector with a chimeric fiber from canine adenovirus type 1 results in novel expanded tropism for cancer gene therapy

Detection and molecular characterization of canine adenovirus type 2 (CAV-2) in dogs with respiratory tract symptoms in shelters in Turkey

Canine respiratory viruses

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