Complete Genome Sequences of 16 Mycoplasma bovis Isolates from Canadian Bison and Cattle

Register, Karen B.; Bayles, Darrell O.; Ma, Hao; Windeyer, M. Claire; Perez-Casal, José; Bras, Ana L.; Suleman, Muhammad; Woodbury, Murray R.; Jelinski, Murray; Alt, David P.

doi:10.1128/mra.00325-20

Cited by 5 publications

(1 citation statement)

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“…Thus, a fuller understanding of the molecular events that andmay have contributed to the emergence of mycoplasmosis in bison requires more extensive genetic characterization of bison isolates. To this end, we have recently sequenced the genomes of a total of 82 bison isolates, 55 from the United States and 27 from Canada, that collectively represent all STs known at this time to infect bison [ 20 , 21 ]. Comprehensive genome-wide analyses, including comparison with data available for cattle isolates, are currently underway.…”

Section: Discussionmentioning

confidence: 99%

Serological evidence for historical and present-day exposure of North American bison to Mycoplasma bovis

Parker

Patyk

et al. 2021

BMC Vet Res

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Background Mycoplasma bovis causes mastitis, otitis, pneumonia and arthritis in cattle and is a major contributor to bovine respiratory disease complex. Around the year 2000, it emerged as a significant threat to the health of North American bison. Whether healthy bison are carriers of M. bovis and when they were first exposed is not known. To investigate these questions we used a commercially available ELISA that detects antibodies to M. bovis to test 3295 sera collected from 1984 through 2019 from bison in the United States and Canada. Results We identified moderately to strongly seropositive bison from as long ago as the late 1980s. Average seroprevalence over the past 36 years is similar in the United States and Canada, but country-specific differences are evident when data are sorted by the era of collection. Seroprevalence in the United States during the pre-disease era (1999 and prior) was significantly higher than in Canada, but was significantly lower than in Canada during the years 2000–2019. Considering individual countries, seroprevalence in the United States since the year 2000 dropped significantly as compared to the years 1985–1999. In Canada the trend is reversed, with seroprevalence increasing significantly since the year 2000. ELISA scores for sera collected from free-ranging bison do not differ significantly from scores for sera from more intensively managed animals, regardless of the era in which they were collected. However, seroprevalence among intensively raised Canadian bison has nearly doubled since the year 2000 and average ELISA scores rose significantly. Conclusions Our data provide the first evidence that North American bison were exposed to M. bovis many years prior to the emergence of M. bovis-related disease. Patterns of exposure inferred from these results differ in the United States and Canada, depending on the era under consideration. Our data further suggest that M. bovis may colonize healthy bison at a level sufficient to trigger antibody responses but without causing overt disease. These findings provide novel insights as to the history of M. bovis in bison and will be of value in formulating strategies to minimize the impact of mycoplasmosis on bison health and production.

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Section: Discussionmentioning

confidence: 99%