Complete mesocolic excision does not increase short-term complications in laparoscopic left-sided colectomies: a comparative retrospective single-center study

Complete mesocolic excision versus conventional surgery for colon cancer: A systematic review and meta‐analysis

“…Title and abstract screening excluded 2325 studies, while 10 additional papers were identified using backwards chaining. Therefore, 148 studies underwent full‐text reviews and 31 studies were included in our review (Figure 1) [8,10,13,20–47]. The grey literature review did not identify any additional full publications.…”

“…Of the 31 included studies, 26 reported mean age [10,13,20–27,29,31,33–47] and 30 reported sex [8,10,13,20–27, 29–47] (Table 1), evenly matched between cohorts. Mean age in the CME/D3 cohort was 68.7 years (range 18–93) versus 68.5 years (range 18–92) in conventional surgery, while male sex was 54.1% (38.8%–85%) and 51.5% (39.5%–70%) respectively.…”

“…Fifteen of 31 studies reported operative duration [20,22,26–28,30,34–38,40,41,45,46] and intra‐operative blood loss [20,22,23,27,28,30,34–40, 45,46]. There was an increased operative time in the CME/D3 compared to the conventional cohort (weighted mean difference [WMD] 27.7 min, 95% CI 1.11–54.3, P = 0.041) (Table 2) but no difference in blood loss between cohorts (WMD 3.50 ml, 95% CI −29.13–36.12, P = 0.834).…”

“…There was an increased operative time in the CME/D3 compared to the conventional cohort (weighted mean difference [WMD] 27.7 min, 95% CI 1.11–54.3, P = 0.041) (Table 2) but no difference in blood loss between cohorts (WMD 3.50 ml, 95% CI −29.13–36.12, P = 0.834). Twenty‐one studies pooled overall complications [13,20,22,23,25–28,30,33–41,45–47] and there was no difference between the two groups (relative risk [RR] 1.06, 95% CI 0.97–1.14, P = 0.189). Eighteen of these 21 studies reported anastomotic leak rate [13,20,22,23,26–28,30,33–34,37–41,45–47] which also showed no differences between the two groups (RR 1.02, 95% CI 0.81–1.29, P = 0.849).…”

“…PopulationcharacteristicsOf the 31 included studies, 26 reported mean age[10,13,[20][21][22][23][24][25][26][27]29,31,[33][34][35][36][37][38][39][40][41][42][43][44][45][46][47] and 30 reported sex[8,10,13,[20][21][22][23][24][25][26][27][29][30][31][32][33][34][35][36][37][38][39][40][41][42]…”