Complete mesocolic excision for colon cancer: is now the time for a change in practice?

West, Nicholas P.

doi:10.1016/s1470-2045(19)30573-x

Cited by 7 publications

(2 citation statements)

References 8 publications

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“… 1 Complete mesocolic excision (CME) for CC has recently gained popularity with high-quality surgery. 2 This technique has become increasingly popular in recent years after evidence of increased disease-free survival (DFS) after CME in 2009. 3 Bertelsen et al 4 report the 5-year outcomes with a significant reduction in recurrence to 9.7% in patients of the CME group versus 17.9% for those undergoing non-CME surgery in Union for International Cancer Control (UICC) 5th stage I–III for right-sided CC.…”

Section: Introductionmentioning

confidence: 99%

Lymph node harvesting after laparoscopic complete mesocolic excision colectomy in colon cancer with practical application of glacial acid, absolute ethanol, water, and formaldehyde solution: A prospective cohort study

Nguyen,

Dang,

Song Nguyen

et al. 2024

SAGE Open Medicine

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Objectives: Quality of surgery has recently become an essential topic in the prognosis of colon cancer. Complete mesocolic excision for colon cancer has recently gained popularity with high-quality surgery. Patient specimens after complete mesocolic excision with central vessel ligation procedures have an integrity of the mesocolon and the yield of three fields of lymph node harvest. We apply the glacial acid, absolute ethanol, water, and formaldehyde solution to each specimen based on the Japanese classification of lymph node groups and station numbers. We aim to identify the distribution and status of lymph node metastasis according to each tumor site and some pathological characteristics related to this disease. Methods: A prospective cohort study was performed on 45 laparoscopic complete mesocolic excision surgery patients. Results: 2791 lymph nodes were harvested after complete mesocolic excision surgery. The average number was 62.0 ± 22.3 nodes. The mean tumor size (in the largest dimension) was 4.2 ± 1.8 cm. The average length of the resected bowel segments was 29.1 ± 7.7 cm. There are 63 (2.3%) node metastases in 2791 lymph nodes, in which 17/45 (37.8%) patients had pN(+). The minimum positive node size was 1 mm. The positive pericolic lymph nodes (station 1) accounted for the highest rate, with 53 nodes (1.9%). The number of lymph nodes in young age ⩽60 is more significant than in older. The results were similar, with a more significant node retrieval in the group with a tumor size >4.5 cm and specimen length >25 cm. The number of lymph nodes in lower tumor invasive (pT1,3) was smaller than pT4. Our research shows that the cecum, ascending, and descending colon had greater nodes than others, with a mean number of 78.6, 74.2, and 71.3, respectively. Conclusions: The metastasis and harvested lymph nodes accounted for the highest rate of colon cancer in station 1 and the lowest rate in station 3. The number of retrieved lymph nodes was significantly associated with tumor location, size, specimen length, and patient age.

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Section: Introductionmentioning

confidence: 99%

Lymph node harvesting after laparoscopic complete mesocolic excision colectomy in colon cancer with practical application of glacial acid, absolute ethanol, water, and formaldehyde solution: A prospective cohort study

Nguyen,

Dang,

Song Nguyen

et al. 2024

SAGE Open Medicine

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“…Colon cancer is ranked the third most frequent malignancy all over the world, and the fourth most common cancer in Iran [1,2]. According to Global Cancer Observatory statistics, the colon cancer incidence and mortality rate are increasing rapidly.…”

Section: Introductionmentioning

confidence: 99%

Association Between Heavy Metals and Colon Cancer: An Ecological Study Based on Geographical Information Systems in Northeastern Iran

Kiani

Amin

Bagheri

et al. 2020

Preprint

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BackgroundExposure to environmental pollutants such as heavy metals has been introduced as a possible contributor to increasing the risk of colon cancer. We aim to explore the associations between heavy metals and the age-standardized incidence rate (ASR) colon cancer in Northeastern Iran.MethodsCancer data were drawn from the population-based cancer registry of Golestan province, Northeastern Iran. The heavy metals’ samples were collected from 69 rice milling plants in the study area. Then, the concentration level of seven heavy metals, including Cadmium, Nickel, Cobalt, Copper, Selenium, Lead, and Zink was measured. The Kriging algorithm was used to interpolate the heavy metals' concentration on the surface of the study area. The exploratory regression analysis was conducted to build the ordinary least squares (OLS) models on every possible combination of the candidate explanatory variables. Finally, the best OLS models were chosen to show the effect of heavy metals on colon cancer.ResultsGenerally, heavy metals were higher in central part of the province. The analyses showed that the high concentration of Cobalt was associated with the high ASR of colon cancer in men. In contrast, the Selenium concentration was higher in areas with lower ASR of colon cancer in men. A significant regression equation for men colon cancer was found (F(4,137)=38.304, P<.000) with an adjusted R2 of 0.77. The predicted ASR of men colon cancer was -58.3581 with the coefficients for Cobalt= 120.329780; Cadmium= 80.603505; Selenium= -6.069037; Nickel= -3.086802; and Zink= -0.405843. The effect of Copper and Lead on men colon cancer was not significant. We did not find a significant model for women colon cancer.ConclusionThere may be a possible negative correlation between selenium concentration and lower risk of colon cancer in men. Furthermore, the higher cobalt concentration may be related to an increased risk of men colon cancer.

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Robotic Right Colectomy with Complete Mesocolic Excision and Central Vascular Ligation. Extended Right Colectomy

Ceccarelli,

Bugiantella,

Mariani

et al. 2023

Updates in Surgery

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Complete mesocolic excision for colon cancer: is now the time for a change in practice?

Abstract: This is a repository copy of Complete mesocolic excision for colon cancer: is now the time for a change in practice?.

Cited by 7 publications

References 8 publications

Lymph node harvesting after laparoscopic complete mesocolic excision colectomy in colon cancer with practical application of glacial acid, absolute ethanol, water, and formaldehyde solution: A prospective cohort study

Lymph node harvesting after laparoscopic complete mesocolic excision colectomy in colon cancer with practical application of glacial acid, absolute ethanol, water, and formaldehyde solution: A prospective cohort study

Association Between Heavy Metals and Colon Cancer: An Ecological Study Based on Geographical Information Systems in Northeastern Iran

Robotic Right Colectomy with Complete Mesocolic Excision and Central Vascular Ligation. Extended Right Colectomy

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