Complete mesocolic resection and extended lymphadenectomy for colon cancer: a systematic review

Killeen, Shane; Mannion, M.; Devaney, A.; Winter, D. C.

doi:10.1111/codi.12616

Cited by 112 publications

(63 citation statements)

References 45 publications

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“…1 The weighted mean local recurrence rate in 5 years is approximately 4.5%. 2 It has been estimated that the number of deaths due to colorectal cancer will reach approximately 376 700 by 2020 in Asia. 3 Therefore, a better understanding of the molecular events involved in the prognosis of colon cancer is necessary and conducive to cancer detection and treatment.…”

Section: Introductionmentioning

confidence: 99%

Association of Mixed Lineage Kinase Domain-Like Protein Expression With Prognosis in Patients With Colon Cancer

Guo

An-wei

et al. 2016

Technol Cancer Res Treat

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Background: The mixed lineage kinase domain-like protein has recently been identified as a key downstream component of tumor necrosis factor-induced necroptosis, which is an important pathway of cancer cell death. The goal of the current study is to explore the expression of mixed lineage kinase domain-like protein in colon cancer tissues and evaluate the prognostic value in patients with colon cancer. Methods: We collected normal and cancer colon tissues from 135 patients diagnosed with colon cancer after radical operation during July 2007 to April 2009 at The Affiliated Hospital of Qingdao University. Immunohistochemistry analysis was scored using an established scoring system. Kaplan-Meier survival curves were generated for recurrence-free survival and overall survival for all patients and 2 subsets of patients. The relationship between mixed lineage kinase domain-like protein expression and prognosis parameter (recurrence-free survival, overall survival) was analyzed by univariate and multivariate Cox regression analyses. Results: The median age of all patients was 67 years and 56.3% were male. Low expression of mixed lineage kinase domain-like protein was associated with decreased overall survival (78.6 vs 81.2 months; P ¼ .011) in all patients. In the subset of 79 patients who received adjuvant chemotherapy, low expression of mixed lineage kinase domain-like protein was associated with decreased recurrence-free survival (60.4 vs 72.8 months; P ¼ .032) and decreased overall survival (66.3 vs 72.9 months; P ¼ .005). Low expression of mixed lineage kinase domain-like protein was associated with decreased overall survival (74.9 vs 79.8 months; P ¼ .006) and recurrence-free survival (69.6 vs 78.8 months; P ¼ .005) among patients with Tumor Node Metastasis (TNM) stage II colon cancer. Conclusions: Low expression of mixed lineage kinase domain-like protein was associated with decreased overall survival in all patient-group with resected colon cancer. It is associated with decreased recurrencefree survival and overall survival in the subset of patients who receive adjuvant chemotherapy and patients who were TNM stage II. Mixed lineage kinase domain-like protein may provide important prognostic information in patients with colon cancer.

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Section: Introductionmentioning

confidence: 99%

Association of Mixed Lineage Kinase Domain-Like Protein Expression With Prognosis in Patients With Colon Cancer

Guo

An-wei

et al. 2016

Technol Cancer Res Treat

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“…44,45 In their systematic review, Killeen et al reported 5-year local recurrence rate, overall survival rate, and disease-free survival rate of 4.5%, 58.1%, and 77.4%, respectively. 46 However, studies comparing laparoscopic excision to open CME raised issues regarding the completeness of laparoscopic excision for tumors near the flexures or in the transverse colon. 47,48 Authors attributed this to the technical difficulty of achieving a proximal ligation of the middle colic vessels laparoscopically, possibly explaining why transverse colectomies were excluded from most trials comparing laparoscopic versus open surgery for colorectal cancer.…”

mentioning

confidence: 99%

The da Vinci Xi: a review of its capabilities, versatility, and potential role in robotic colorectal surgery

Ngu¹,

Tsang²,

Koh³

2017

RSRR

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Abstract:The Xi is the latest da Vinci surgical system approved for use in colorectal surgery. With its novel overhead architecture, slimmer boom-mounted arms, extended instrument reach, guided targeting, and integrated auxiliary technology, the Xi manages to address several limitations of earlier models. The versatility of this new system allows it to be implemented in a wide range of colorectal procedures -from complex multiquadrant colectomies to challenging mesorectal dissections in the pelvis. While commonly criticized for its cost and prolonged operative time, robotic colorectal surgery holds the potential for enhanced ergonomics, superior precision, and a reduction in the learning curve involved in training an expert surgeon. This review appraises the existing literature on robotic colorectal surgery while elaborating how the improved capabilities of the Xi serve to usher in a new era of minimally invasive colorectal surgery.

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“…In a systematic review of 5,246 patients with right colon cancer, the 5-year DFS rate was 77.4% and the 5-year overall survival rate was 58.1% with a mean follow-up of 60 months. The local recurrence rate was 4.5% [25]. In the same review [25], the CME group saw more advantageous oncologic outcomes compared to the non-CME group.…”

Section: Discussionmentioning

confidence: 84%

“…The local recurrence rate was 4.5% [25]. In the same review [25], the CME group saw more advantageous oncologic outcomes compared to the non-CME group. It is possible that the improved outcomes of CME patients are related to the resection plane and the vessel site of ligation [26].…”

Section: Discussionmentioning

confidence: 84%

Short-Term and Long-Term Outcomes of Complete Mesocolic Excision with Central Vascular Ligation for Ascending Colon Cancer: Single Institution

Jang¹,

Lim²,

Kuk³

et al. 2017

Surgery Curr Res

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Purpose: The aim of the present study was to analyze the peri-and post-operative and oncologic outcomes for ascending colon cancer after complete mesocolic excision (CME) with central vessel ligation (CVL). Materials and methods:The data of 156 patients who underwent CME with CVL for ascending colon cancer between January 2000 and December 2011 were retrieved from a prospective database. Results:The median follow-up time was 63.6 months. The mean operation time was 191.6 min. The mean blood loss was 85.6 ml. The mean length of the hospital stay was 13.9 days. The mean number of total harvested lymph nodes was 30.3. A 5-year cancer-specific survival (CSS) rate was seen in 83.0% of patients, and a 5-year diseasefree survival (DFS) rate was seen in 79.7%. In stage I, the DFS and CSS rates were both 100%. In stage II, the DFS rate was 91.0% and the CSS rate was 92.3%. In stage III, the DFS rate was 53.5% and the CSS rate was 59.5%. In stage IIIa, the DFS and CSS rates were both 100%. In stage IIIb, the DFS rate was 70.1% and the CSS rate was 92.1%. In stage IIIc, the DFS rate was 19.4% and the CSS rate was 44.0% (p<0.01). The local recurrence rate was 3.8%. Conclusion:Based on the present data, CME with CVL is feasible and safe for treating ascending colon cancer. CME with CVL could lead to better oncologic outcomes for ascending colon cancer surgery.

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Complete mesocolic resection and extended lymphadenectomy for colon cancer: a systematic review

Abstract: The available data for CME and EL have numerous fundamental limitations that prohibit adoption. Contemporary controlled studies are required before universal recommendation.

Cited by 112 publications

References 45 publications

Association of Mixed Lineage Kinase Domain-Like Protein Expression With Prognosis in Patients With Colon Cancer

Association of Mixed Lineage Kinase Domain-Like Protein Expression With Prognosis in Patients With Colon Cancer

The da Vinci Xi: a review of its capabilities, versatility, and potential role in robotic colorectal surgery

Short-Term and Long-Term Outcomes of Complete Mesocolic Excision with Central Vascular Ligation for Ascending Colon Cancer: Single Institution

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