Complete Philtrum Reconstruction on the Partial-Thickness Cross-Lip Flap by Nasolabial Muscle Tension Line Group Reconstruction in the Same Stage of Flap Transfer

Yin, Ningbei; Wu, Di; Wang, Yongqian; Song, Tao; Li, Haidong; Jiang, Chenchen; Ma, Hongbing; Zhao, Zhihui

doi:10.1001/jamafacial.2017.0296

Cited by 14 publications

(14 citation statements)

References 12 publications

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“…This method enables detailed visualization of the muscle fibers. We utilized this method to study the nasolabial muscles and those at the corner of the mouth, obtaining satisfactory results (Yin et al, 2015, 2017; Ma et al, 2016; Wu and Yin, 2016; Jiang et al, 2018; Sun et al, 2018). In this study, after micro-CT scanning, all images showed good contrast between the connective tissues and muscle fibers, allowing detailed morphologic observations of the muscle fibers in the 2-D projection images, including their insertion and connections.…”

Section: Discussionmentioning

confidence: 99%

Micro-Computed Tomography-Based Three-Dimensional Anatomical Structure of the Region Around the Pterygoid Hamulus

Zhao

Wang

et al. 2021

The Cleft Palate Craniofacial Journal

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Objective Palatoplasty would involve the structures around the pterygoid hamulus. However, clinicians hold different opinions on the optimal approach for the muscles and palatine aponeurosis around the pterygoid hamulus. The absence of a consensus regarding this point can be attributed to the lack of investigations on the exact anatomy of this region. Therefore, we used micro-computed tomography to examine the anatomical structure of the region surrounding the pterygoid hamulus. Design Cadaveric specimens were stained with iodine–potassium iodide and scanned by micro-computed tomography to study the structures of the tissues, particularly the muscle fibers. We imported Digital Imaging and Communications in Medicine images to Mimics to reconstruct a 3-dimensional model and simplified the model. Results Three muscles were present around the pterygoid hamulus, namely the palatopharyngeus (PP), superior constrictor (SC), and tensor veli palatini (TVP). The hamulus connects these muscles as a key pivot. The TVP extended to the palatine aponeurosis, which bypassed the pterygoid hamulus, and linked the PP and SC. Some muscle fibers of the SC originated from the hamulus, the aponeurosis of which was wrapped around the hamulus. There was a distinct gap between the pterygoid hamulus and the palatine aponeurosis. This formed a pulley-like structure around the pterygoid hamulus. Conclusions Transection or fracture of the palatine aponeurosis or pterygoid hamulus, respectively, may have detrimental effects on the muscles around the pterygoid hamulus, which play essential roles in the velopharyngeal function and middle ear ventilation. Currently, cleft palate repair has limited treatment options with proven successful outcomes.

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Section: Discussionmentioning

confidence: 99%

Micro-Computed Tomography-Based Three-Dimensional Anatomical Structure of the Region Around the Pterygoid Hamulus

Zhao

Wang

et al. 2021

The Cleft Palate Craniofacial Journal

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“…A similar flap like the Estlander flap is a single-stage reconstruction, whose point of rotation is at the commissure 13,18 . Abbe flap and Estlander flap are cross-lip flaps; both can be used for reconstruction of full-thickness defects affecting 30% to 60% of the width of either lip medial to the commissure 19,20 . As for a large fullthickness defect greater than two-thirds of the lip, transfer of tissue from distant sites or adjacent cheek tissue is needed to avoid microstomia 13 .…”

Section: Discussionmentioning

confidence: 99%

“…13,18 Abbe flap and Estlander flap are cross-lip flaps; both can be used for reconstruction of full-thickness defects affecting 30% to 60% of the width of either lip medial to the commissure. 19,20 As for a large fullthickness defect greater than two-thirds of the lip, transfer of tissue from distant sites or adjacent cheek tissue is needed to avoid microstomia. 13 Nasolabial fold flap, bilateral cheek advancement flaps, Webster technique, flaps from the scalp and forehead, and submandibular, deltopectoral, pectoralis-major, sternocleidomastoid have been described in reconstruction of large full-thickness lip defects.…”

Section: Discussionmentioning

confidence: 99%

Transposition Mucosal Flap Combined With Autologous Fat Transplantation to Repair Lip Defects Caused by Sclerotherapy of Hemangioma

Wang

Zhao

et al. 2021

Journal of Craniofacial Surgery

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Infantile hemangiomas are the most common benign childhood tumors and can occur on any part of the human body. Sclerosing agents are used in the early stage of treatment of infantile hemangioma. Sometimes a lip defect remains after sclerosing agent treatment. We developed a simple technique to repair lip defects. The authors performed transposition mucosal flap and autologous fat transplantation surgery on patients who had lip defects caused by sclerosing agents. The flap was transposed 908 from the intraoral labial mucosa to the vermilion defect. Autologous fat was transplanted to the white lip defect. If necessary, a secondary fat transplantation may be performed every half year. All patients were followed up to evaluate the effect of the operation. Patients were asked to rate their satisfaction with the surgery between 1 and 10. Digital three-dimensional evaluation was performed. Sixteen patients underwent the surgery successfully, and the flaps were all viable. No complications occurred after surgery (5 males, 11 females; age range, 5-27 years; 12 upper lip, 3 lower lip, and 1 median lip). The patients were satisfied with the aesthetic outcome of surgery (mean score, 9). Seven patients wanted to undergo a second fat transplantation, whereas 9 patients felt it was unnecessary to transplant fat again. Transposition mucosal flap combined with autologous fat transplantation is reliable and minimally invasive. It is an effective method for repairing moderate lip defects mainly involving vermilion caused by a sclerosing agent.

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“…The main clinical treatment involves induction of apical development with appropriate drugs after infection control. However, drug-induced apical development often and sometimes fails to increase the thickness of root canal wall and tooth resistance, resulting in poor therapeutic effect [12]. Therefore, there is need to develop a biological therapy that can promote the growth of tooth root and regeneration of dentin.…”

Section: Effects Of Erk and P38mapk Signaling Pathways On Mrna And Pr...mentioning

confidence: 99%

Triiodothyronine participates in odontoblast differentiation of apical papilla stem cells through regulation of ERK and p38MAPK signaling pathways

Xu¹,

Li²,

Yang³

2022

Trop. J. Pharm Res

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Purpose: To investigate the effect of triiodothyronine (T3) in odontoblast differentiation of apical papilla stem cells, and the mechanism of action involved. Methods: Apical unclosed permanent molars extracted from patients due to orthodontics and impaction were selected. The extracted teeth were cultured in the isolation stage of SCAP cells. The cells were exposed to different concentrations of T3. The effects of ERK and p38 MAPK signaling pathways on activity of alkaline phosphatase (ALP) were determined. Calcium deposition was measured using a calcium determination kit, while the expression of BMP - 2 protein by T3 was determined by Western blot assay. Fluorescence quantitative polymerase chain reaction (FqPCR) method was used to determine the mRNA expression of BMP. Results: The ALP activities were significantly higher in T3 groups than in control group. Relative to control, there were marked differences in ALP activity and calcium deposition in T3 group, T3 + PD group and T3 + SB group (p < 0.05). Relative to control, the mRNA and protein expressions of BMP-2 in T3 group were increased significantly (p < 0.05). Conclusion: Triiodothyronine regulates the differentiation of apical papilla stem cells into dentin through ERK and p38MAPK signaling pathways. This provides the mechanism underlying odontoblast differentiation of apical papilla stem cells.

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Complete Philtrum Reconstruction on the Partial-Thickness Cross-Lip Flap by Nasolabial Muscle Tension Line Group Reconstruction in the Same Stage of Flap Transfer

Cited by 14 publications

References 12 publications

Micro-Computed Tomography-Based Three-Dimensional Anatomical Structure of the Region Around the Pterygoid Hamulus

Micro-Computed Tomography-Based Three-Dimensional Anatomical Structure of the Region Around the Pterygoid Hamulus

Transposition Mucosal Flap Combined With Autologous Fat Transplantation to Repair Lip Defects Caused by Sclerotherapy of Hemangioma

Triiodothyronine participates in odontoblast differentiation of apical papilla stem cells through regulation of ERK and p38MAPK signaling pathways

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