Complete Surgical Excision Is Effective Treatment for Children With Immature Teratomas With or Without Malignant Elements: A Pediatric Oncology Group/Children's Cancer Group Intergroup Study

Marina, Neyssa; Cushing, Barbara; Giller, Roger; Cohen, Lewis; Lauer, Stephen J.; Ablin, Arthur R.; Weetman, Robert M.; Cullen, John W.; Rogers, Paul C.; Vinocur, Charles D.; Stolar, Charles J.H.; Rescorla, Frederick J.; Hawkins, Edith P.; Heifetz, Stephen A.; Rao, Pejaver V.; Krailo, Mark; Castleberry, Robert P.

doi:10.1200/jco.1999.17.7.2137

Cited by 268 publications

(181 citation statements)

References 34 publications

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“…We correlate these data with clinical characteristics such as age, tumors markers (alpha fetoprotein/AFP), initial imaging and importantly follow-up data such as social security indexlinked mortality, time to recurrence (if any), and postoperative tumor marker measurements. Our data strongly support the conclusion that resected mature sacrococcygeal teratomas in pediatric patients, even those with subsequent recurrences, Characterization of sacrococcygeal teratomas will ultimately have a favorable outcome 20 and suggest that recurrent sacrococcygeal teratomas in postpubertal patients are also indolent.…”

Section: Discussionsupporting

confidence: 82%

Sacrococcygeal teratomas: clinico-pathological characteristics and isochromosome 12p status

et al. 2014

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The biological behavior of teratomas is highly variable, and morphologic features alone are insufficient to predict their clinical course. Prognostic factors that influence behavior include the following: patient sex, age, anatomic site, coincident neoplasm, and cytogenetic abnormalities. Gonadal teratomas have been wellcharacterized; postpubertal testicular teratomas are commonly associated with isochromosome 12p (i12p) and considered to nearly always carry a potential for malignant behavior, whereas ovarian and prepubertal testicular teratomas are i12p negative and predominantly benign in behavior. For extragonadal sites, such as sacrum and coccyx, clinical characteristics and i12p status are yet to be adequately characterized. As part of this study, we identified 19 sacrococcygeal teratomas in our surgical pathology archives from 1990 to 2012. Clinical records and slides were reviewed to confirm the original diagnosis. Gains in chromosome 12p, including i12p status were assessed in representative paraffin sections by fluorescence in situ hybridization. Our cases included 16 mature sacrococcygeal teratomas (11 prepubertal and 5 postpubertal) and three immature saccrococygeal teratomas (all prepubertal). Among mature teratomas, the average tumor size was larger in adults compared with prepubertal patients. A higher number of adult cases were recurrences (80% vs 21%), but only pediatric recurrences were managed with postoperative chemotherapy. All examined tumors were negative for i12p. 100% survival was documented in our cohort with a median follow-up of 6 years. We present a large series of sacrococcygeal teratomas and the first series to examine postpubertal adults at this anatomic site. All tumors lacked chromosome 12p gains, including i12p. Both pre-and postpubertal sacrococcygeal teratomas had a favorable outcome regardless of age or sex.

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Section: Discussionsupporting

confidence: 82%

Sacrococcygeal teratomas: clinico-pathological characteristics and isochromosome 12p status

et al. 2014

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“…48 These correlations may not apply, however, to immature teratomas of the ovary in children since recent work has shown a good outcome with surgery alone, regardless of the degree of immaturity, in these cases. 49,50 Immature ovarian teratomas are associated with gliomatosis peritonei, a favorable prognostic finding if composed of completely mature tissues, 51,52 with the seemingly unexpected recent discovery, using molecular methods, that these glial 'implants' are not tumor derived but represent teratoma-induced metaplasia of submesothelial cells. 53,54 On the other hand, immaturity in postpubertal testicular teratomas has no established significance.…”

Section: Immature Teratoma and Selected Monodermal Teratomasmentioning

confidence: 99%

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues

2005

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“…Although adjuvant therapies (i.e., chemotherapy or radiotherapy) are not recommended with completely resected grades 2 and 3 immature teratomas, optimal treatment in these groups is still controversial [10]. Marina et al suggested that it seems safe to treat all patients with extragonadal immature teratomas by surgical excision followed by close observation, withholding chemotherapy until there is evidence of disease recurrence [10].…”

Section: Discussionmentioning

confidence: 99%

Gastric Teratoma—Unusual Cause of Neonatal Obstructive Jaundice: A Case Report

et al. 2012

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The gastric teratoma is a very rare tumour that usually presents as an abdominal mass, gastrointestinal bleeding with/without features of gastric outlet obstruction. We report a rare case of immature gastric teratoma in a two months old female child who presented with abdominal lump and jaundice. The presentation was a diagnostic challenge and a dilemma, added by the fine needle aspiration cytology (FNAC) suggestive of small round cell tumor, favouring diagnosis of Wilms tumor over Neuroblastoma. Intra-operatively the tumor was found compressing upon the common bile duct (CBD). Final histopathological examination (HPE) revealed immature gastric teratoma Grade III. We wish to highlight this unusual presentation of gastric teratoma manifesting with obstructive jaundice and fallacy of FNAC in the diagnosis of teratomas.

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Complete Surgical Excision Is Effective Treatment for Children With Immature Teratomas With or Without Malignant Elements: A Pediatric Oncology Group/Children's Cancer Group Intergroup Study

Abstract: Surgical excision is safe and effective treatment for 80% to 100% of children with immature teratoma.

Cited by 268 publications

References 34 publications

Sacrococcygeal teratomas: clinico-pathological characteristics and isochromosome 12p status

Sacrococcygeal teratomas: clinico-pathological characteristics and isochromosome 12p status

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues

Gastric Teratoma—Unusual Cause of Neonatal Obstructive Jaundice: A Case Report

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