Completely resected anaplastic thyroid carcinoma combined with adjuvant chemotherapy and irradiation is associated with prolonged survival

Time trend in tumour size and characteristics of anaplastic thyroid carcinoma

“…Haigh et al . reported potentially curative surgery was the only discriminating variable associated with prolonged survival of patients with ATC . In our study, all of the living patients had intrathyroidal ATC, which showed clear resection margin and no lymphovascular invasion except one patient (patient no.…”

Role of surgery in the management of anaplastic thyroid carcinoma: Korean nationwide multicenter study of 329 patients with anaplastic thyroid carcinoma, 2000 to 2012

“…Several studies have shown that long‐term survival could be expected in cases of complete surgical resection . Therefore, these studies have recommended extended radical surgery, including resection of the trachea, larynx, and esophagus, in selected cases.…”

“…Because it has been difficult to determine the outcomes of ATCs in single‐institution studies with small cohorts, we established the ATC multicenter registry, which has accumulated clinical information from hospitals nationwide in Korea, and collected clinical data during the latest period between 2000 and 2012, in contrast to previous studies . The clinical data have been analyzed to identify the prognostic factors and treatment outcomes of ATCs in an attempt to determine helpful therapeutic strategies in individual patients.…”

Clinical Response with Sunitinib Therapy in the Treatment of Anaplastic Thyroid Cancer

“…Even though curative resection of the tumor was unable to be achieved due to involvement of the carotid sheath and trachea, her prolonged state of stable disease for 8 months is comparable to the reported increased median survival in patients receiving triple modality therapy compared to chemotherapy alone or radiotherapy alone (11 months vs. 5.7 months vs. 4 months, respectively) [4]. Another important study by Haigh et al found median survival of 43 months versus 3 months (p = 0.002) in patients receiving curative resection plus adjuvant chemoradiotherapy compared to those who underwent palliative resection and adjuvant chemoradiotherapy, respectively [5]. The addition of sunitinib in our patient likely contributed to the favorable clinical outcome of controlling disease progression or recurrence.…”

“…Although not standardized, management of ATC ideally involves multimodality treatment (consisting of surgery, radiotherapy, and chemotherapy) to maximize clinical outcome, as such management paradigms have been shown to improve survival times [4]. Additionally, multiple studies have shown that performing curative resection confers increased one-year survival rates, as well as increased overall survival times [3,5].…”