Complex analysis of a recurrent pleomorphic hyalinizing angiectatic tumor of soft parts

Wei, Shi; Pan, Zenggang; Siegal, Gene P.; Winokur, Thomas S.; Carroll, Andrew J.; Jhala, Darshana

doi:10.1016/j.humpath.2011.02.023

Cited by 28 publications

(25 citation statements)

References 18 publications

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“…Histologically, Pleomorphic hyalinizing angiectatic tumors possess dilated, thin-walled vessels lined with a layer of hyaline substance composed mostly of fibrin. These are immersed in a network of proliferating spindle and inflammatory cells [1] , [2] , [4] , [5] , [6] , [7] , [8] , [9] . These cells possess hyperchromatic, pleomorphic nuclei and internuclear cytoplasmic inclusions [5] , [6] , [9] .…”

Section: Discussionmentioning

confidence: 99%

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Pleomorphic hyalinizing angiectatic tumor arising in the groin: A case report

Onyemkpa

Oyasiji

2016

International Journal of Surgery Case Reports

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Section: Discussionmentioning

confidence: 99%

“…Although majority of the cases recur as PHAT, rare recurrences with sarcomatous components have been reported. [3] , [5] , [6] , [8] No metastases however have been recorded till date [1] , [3] , [4] , [5] . Due to the biology of these tumors, some experts recommend that they be viewed as locally aggressive, low grade tumors.…”

Section: Discussionmentioning

confidence: 99%

Pleomorphic hyalinizing angiectatic tumor arising in the groin: A case report

Onyemkpa

Oyasiji

2016

International Journal of Surgery Case Reports

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“…Smith et al reported that PHATs usually have an infiltrative margin, and Folpe and Weiss also demonstrated infiltrative growth in all cases of PHAT. However, further cases of demarcated PHAT have been reported, and among those in which the tumor's macroscopic appearance was described, 25 had an infiltrative margin and 16 had a demarcated margin. The tumor demarcation in the present case may be related to marked intratumoral hemorrhage, which may in turn be derived from vascular permeability induced by intratumoral mast‐cell products .…”

Section: Discussionmentioning

confidence: 99%

A case of a pleomorphic hyalinizing angiectatic tumor of soft parts with intracytoplasmic hemosiderin pigment apparent upon fine‐needle aspiration cytology

Yorita

Ishihara

Tokumitsu

et al. 2014

Diagnostic Cytopathology

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Pleomorphic hyalinizing angiectatic tumors of soft parts are extremely rare low‐grade mesenchymal lesions that frequently occur subcutaneously, especially in the lower extremity. The tumor is histologically characterized by sheets of plump, spindled or rounded cells, and clusters of ectatic blood vessels. It also has a number of previously characterized cytological features such as pleomorphic cells, intranuclear pseudoinclusion, and intracytoplasmic hemosiderin pigments. However, intracytoplasmic hemosiderin has not been carefully evaluated in cytology specimens. Here, we report the case of a 56‐year‐old Japanese man with an encapsulated pleomorphic hyalinizing angiectatic tumor of soft parts that included fine and coarse hemosiderin‐laden tumor cells. The tumor was clinically followed up as a hematoma, but malignant tumors, including malignant melanoma, were suspected because aspiration cytology specimens contained pleomorphic cells with intracytoplasmic brown pigments. The tumor was closely associated with an intratumoral hematoma and a few microscopic satellite lesions. Pleomorphic hyalinizing angiectatic tumor of soft parts should be included in the differential cytological diagnosis of soft tissue tumors if the three cytological features described earlier are present. Enucleation therapy could facilitate local recurrence, as the tumor may have the potential to infiltrate surrounding soft tissue or form satellite lesions. Diagn. Cytopathol. 2015;43:407–411. © 2014 The Authors. Diagnostic Cytopathology Published by Wiley Periodicals, Inc.

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“…32,33 A single case report of PHAT/HFLT showed a complex karyotype 45,XX,der(1)t(1;3)(p31;q12),À3,der(10)t(1;10)(p31;q25) [11]/ 46,XX [4]. 34 However, FISH was not performed to confirm that the translocation t(1;10)(p31;q25), which is different from the typical t(1;10)(p22;q24), occurred within the genomic loci of TGFBR3 and MGEA5.…”

Section: Pleomorphic Hyalinizing Angiectatic Tumors Of Soft Partsmentioning

confidence: 99%

The t(1;10)(p22;q24) TGFBR3/MGEA5 Translocation in Pleomorphic Hyalinizing Angiectatic Tumor, Myxoinflammatory Fibroblastic Sarcoma, and Hemosiderotic Fibrolipomatous Tumor

Liu

Sukov

2018

Archives of Pathology &Amp; Laboratory Medicine

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- Diagnosis of HFLT, PHAT, and MIFS is challenging because of a lack of unique morphologic, immunophenotypic, molecular, and cytogenetic markers. The recurrent t(1;10)(p22;q24) translocation and/or TGFBR3/MGEA5 rearrangement was reported in 55 patients, with a relatively even distribution among HFLT, PHAT, and MIFS (17 HFLT, 15 MIFS, 13 MIFS/HFLT, and 10 PHAT). This indicates that current morphology-based diagnostic criteria do not identify reliably the subset of soft tissue tumor with t(1;10) translocation. Genetic heterogeneity of these tumors is supported by the recent detection of a mutually exclusive, second recurrent genetic change, t(7;17) TOM1L2-BRAF translocation or BRAF amplification, in a subset of MIFS.

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Complex analysis of a recurrent pleomorphic hyalinizing angiectatic tumor of soft parts

Cited by 28 publications

References 18 publications

Pleomorphic hyalinizing angiectatic tumor arising in the groin: A case report

Pleomorphic hyalinizing angiectatic tumor arising in the groin: A case report

A case of a pleomorphic hyalinizing angiectatic tumor of soft parts with intracytoplasmic hemosiderin pigment apparent upon fine‐needle aspiration cytology

The t(1;10)(p22;q24) TGFBR3/MGEA5 Translocation in Pleomorphic Hyalinizing Angiectatic Tumor, Myxoinflammatory Fibroblastic Sarcoma, and Hemosiderotic Fibrolipomatous Tumor

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