Complex approach to mental disorders after Chernobyl accident estimation

Titievsky, S.V.; Tabachnikov, S. I.; Кутько, И. И.

doi:10.1016/s0006-3223(97)86945-4

Cited by 3 publications

(1 citation statement)

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“…Several studies have reported that the youngest children in the contaminated areas are developing thyroid cancer [4], bone disorders [5], and nervous and digestive system disorders [6,7]. As a few animal experiments have assessed the biological effects of chronic exposure to 137 Cs, we studied the results of 137 Cs contamination of rats on various physiological systems.…”

Section: Introductionmentioning

confidence: 99%

Chronic Contamination of Rats with 137Cesium Radionuclide: Impact on the Cardiovascular System

Guéguen

Lestaevel²,

Grandcolas³

et al. 2008

Cardiovasc Toxicol

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Cardiovascular system impairment has been observed in children and in liquidators exposed to the Chernobyl nuclear power plant accident. No experimental studies of animals have analyzed whether these disorders might be attributed to chronic ingestion of low levels of cesium 137 ((137)Cs). Biochemical, physiological, and molecular markers of the cardiovascular system were analyzed in rats exposed through drinking water to (137)Cs at a dose of 500 Bq kg(-1) (6500 Bq l(-1)). Plasma concentrations of CK and CK-MB were higher (+52%, P < 0.05) in contaminated rats. No histological alteration of the heart was observed, but gene expression was modified in the atria. Specifically, levels of ACE (angiotensin converting enzyme) and BNP (brain natriuretic peptide) gene expression increased significantly (P < 0.05). ECG analysis did not disclose any arrhythmia except ST- and RT-segment shortening (-9% and -11%, respectively, P < 0.05) in rats exposed to (137)Cs. Mean blood pressure decreased (-10%, P < 0.05), and its circadian rhythm disappeared. Overall, chronic contamination by an extreme environmental dose of (137)Cs for 3 months did not result in cardiac morphological changes, but the cardiovascular system impairments we observed could develop into more significant changes in sensitive animals or after longer contamination.

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Section: Introductionmentioning

confidence: 99%