Complex approaches to assessing the pesticides risk on human health and environment

Djangalina, E. D.; Altynova, Nazym; Mit, Natalya; Djansugurova, Leyla

doi:10.1016/b978-0-323-90489-6.00007-0

Cited by 2 publications

(3 citation statements)

References 115 publications

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“…For instance, the presence of AZO contamination has been detected in freshwater ecosystems in South Africa and China, alongside other organic pollutants [6,7]. One major concern associated with AZO is its significant threat Polymers 2024, 16, 1394 2 of 13 to aquatic ecosystems due to its highly toxic nature. According to the European Food Safety Authority, AZO can rapidly eradicate up to 50% of aquatic organisms within a short period, even at concentrations as low as 1 mgL −1 [8].…”

Section: Introductionmentioning

confidence: 99%

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Molecularly Imprinted Polymer-Based Electrochemical Sensor for the Detection of Azoxystrobin in Aqueous Media

Nguyen,

Reut,

Rappich

et al. 2024

Polymers

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This work presents an electrochemical sensor detecting a fungicide-azoxystrobin (AZO) in aqueous environments. This AZO sensor utilizes a thin-film metal electrode (TFME) combined with an AZO-selective molecularly imprinted polymer (AZO–MIP). The AZO–MIP was directly generated on TFME through electrochemical polymerization from the solution containing two functional monomers: aniline (Ani) and m-phenylenediamine (mPD), and the template: AZO, which was afterwards removed to form AZO-selective cavities in the polymer matrix. The AZO–MIP preparation was characterized by electrochemical and ellipsometry measurements. Optimization of the synthesis parameters, including the charge density applied during electrodeposition, the monomer-to-template ratio, was performed to enhance the sensor’s performance. The results demonstrated that the AZO sensor achieved a low limit of detection (LOD) of 3.6 nM and a limit of quantification (LOQ) of 11.8 nM in tap water, indicating its sensitivity in a complex aqueous environment. The sensor also exhibited satisfactory selectivity for AZO in both ultrapure and tap-water samples and achieved a good recovery (94–119%) for the target analyte. This study highlights the potential of MIP-based electrochemical sensors for the rapid and accurate detection of fungicide contaminants in water, contributing to the advancement of analytical tools for water-quality monitoring and risk assessment.

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Section: Introductionmentioning

confidence: 99%

“…Extended exposure to AZO has been associated with suppression of mitochondrial oxidative respiration and changes in neuronal cell lipid abundance [15]. Also, genotoxic activity risk has been identified, showing varying effects with short-term and long-term exposure, depending on age groups [16].…”

Section: Introductionmentioning

confidence: 99%

Molecularly Imprinted Polymer-Based Electrochemical Sensor for the Detection of Azoxystrobin in Aqueous Media

Nguyen,

Reut,

Rappich

et al. 2024

Polymers

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“…This study is part of the results of a complex project devoted to evaluating the ecological situation of populated territories of the Almaty region contaminated by banned organochlorine pesticides over 10 years. The results indicated that organochlorine pesticides and their decay products entered the human food chain and influenced the level of chromosome aberrations and somatic health status [ 15 , 16 , 17 , 18 , 19 , 20 ]. The impact of many factors on health status was estimated in a recently published article [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Case-Control Study of the Association between Single Nucleotide Polymorphisms of Genes Involved in Xenobiotic Detoxification and Antioxidant Protection with the Long-Term Influence of Organochlorine Pesticides on the Population of the Almaty Region

Altynova,

Khamdiyeva,

Garshin

et al. 2023

Toxics

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The association of genetic polymorphisms with the individual sensitivity of humans to the action of pesticide pollution is being actively studied in the world. The aim of this study was a molecular epidemiological analysis of candidate polymorphisms of genes involved in pesticide metabolism, detoxification, and antioxidant protection. Some of the selected polymorphisms also relate to susceptibility to cancer and cardiovascular, respiratory, and immune system diseases in individuals exposed to pesticides for a long time. For a case-control study of a unique cohort of people exposed to organochlorine pesticides for 10 years or more were chosen, a control cohort was selected that matched with the experimental group by the main population characteristics. PCR-PRLF and genome-wide microarray genotyping (GWAS) methods were used. We identified 17 polymorphisms of xenobiotic detoxification genes and 27 polymorphisms of antioxidant defense genes, which had a significantly high statistical association with the negative impact of chronic pesticide intoxication on human health. We also found 17 polymorphisms of xenobiotic detoxification genes and 12 polymorphisms of antioxidant defense genes that have a protective effect. Data obtained added to the list of potential polymorphisms that define a group at high risk or resistant to the negative effects of pesticides.

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Complex approaches to assessing the pesticides risk on human health and environment

Cited by 2 publications

References 115 publications

Molecularly Imprinted Polymer-Based Electrochemical Sensor for the Detection of Azoxystrobin in Aqueous Media

Molecularly Imprinted Polymer-Based Electrochemical Sensor for the Detection of Azoxystrobin in Aqueous Media

Case-Control Study of the Association between Single Nucleotide Polymorphisms of Genes Involved in Xenobiotic Detoxification and Antioxidant Protection with the Long-Term Influence of Organochlorine Pesticides on the Population of the Almaty Region

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