Complex evolution and epidemiology of Dobrava-Belgrade hantavirus: definition of genotypes and their characteristics

Klempa, Boris; Avšič–Županc, Tatjana; Clément, Jan; Dzagurova, Tamara K.; Henttonen, Heikki; Heyman, Paul; Jakab, Ferenc; Krüger, Detlev H.; Maes, Piet; Papa, Anna; Ткаченко, Е. А.; Ulrich, Rainer G.; Vapalahti, Olli; Vaheri, Antti

doi:10.1007/s00705-012-1514-5

Cited by 103 publications

(100 citation statements)

References 77 publications

(133 reference statements)

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“…Infections by DOBV-Dobrava in the Balkans cause moderate to severe disease with case fatality rates of 10-12%, whereas our investigations of large HFRS outbreaks in Russia due to DOBV-Kurkino infections showed mild to moderate courses with 0.3-0.9% case fatality (Dzagurova et al, 2009;Klempa et al, 2013a;Papa, 2012).…”

Section: Clinical Epidemiologycontrasting

confidence: 63%

“…Unfortunately, all strains associated with striped field mice (A. agrarius) are designated as Saaremaa virus by some authors regardless of their phylogenetic relationship with other DOBV lineages which often leads to confusion. In accordance with the four phylogenetic lineages, we have recently proposed a subdivision of the DOBV species into 4 genotypes, named Dobrava, Kurkino, Saaremaa, and Sochi according to the geographical place where the first strain of the genotype was molecularly detected (Klempa et al, 2013a) and will use this classification throughout this review. Two of the defined genotypes, Dobrava (associated with yellow necked mouse, A. flavicollis) and Kurkino (associated with A. agrarius) have been molecularly detected in Central Europe.…”

Section: Dobrava-belgrade Virusmentioning

confidence: 99%

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The broad spectrum of hantaviruses and their hosts in Central Europe

Klempa¹,

Radosa²,

Dh³

2013

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Summary. -Hantaviruses are considered to be emerging viruses due to their increasing significance as human pathogens and their cyclic reappearance during outbreaks. Central Europe is an important endemic region for hantavirus infections. Reflecting the presence of all relevant small mammals serving as reservoir hosts, close to all recognized European hantaviruses occur also in Central Europe. Important human pathogens, Puumala and Dobrava-Belgrade viruses, are present and cause hemorrhagic fever with renal syndrome of various severities. Moreover, several of the newly recognized shrew-and mole-borne hantaviruses are present. In this review, we summarize current data on molecular detection of hantaviruses in reservoir hosts as well as on molecular epidemiology of human hantavirus infections in Central Europe.

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Section: Clinical Epidemiologycontrasting

confidence: 63%

Section: Dobrava-belgrade Virusmentioning

confidence: 99%

The broad spectrum of hantaviruses and their hosts in Central Europe

Klempa¹,

Radosa²,

Dh³

2013

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“…In Europe bank voleassociated Puumala virus (PUUV), different genotypes of Dobrava-Belgrade virus (DOBV) hosted by various Apodemus species and perhaps Tula virus (TULV) cause hemorrhagic fever with renal syndrome (HFRS) of different severity (Heyman et al 2011, Klempa et al 2013. For some other viral agents, such as lymphocytic choriomeningitis virus (LCMV) and cowpox virus (CPXV), a member of the genus Orthopoxvirus (OPV), the role of rodent reservoirs in Central Europe is unknown.…”

mentioning

confidence: 99%

Multiple Infections of Rodents with Zoonotic Pathogens in Austria

Schmidt

Eßbauer

Mayer‐Scholl

et al. 2014

Vector-Borne and Zoonotic Diseases

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Rodents are important reservoirs for a large number of zoonotic pathogens. We examined the occurrence of 11 viral, bacterial, and parasitic agents in rodent populations in Austria, including three different hantaviruses, lymphocytic choriomeningitis virus, orthopox virus, Leptospira spp., Borrelia spp., Rickettsia spp., Bartonella spp., Coxiella burnetii, and Toxoplasma gondii. In 2008, 110 rodents of four species (40 Clethrionomys glareolus, 29 Apodemus flavicollis, 26 Apodemus sylvaticus, and 15 Microtus arvalis) were trapped at two rural sites in Lower Austria. Chest cavity fluid and samples of lung, spleen, kidney, liver, brain, and ear pinna skin were collected. We screened selected tissue samples for hantaviruses, lymphocytic choriomeningitis virus, orthopox viruses, Leptospira, Borrelia, Rickettsia, Bartonella spp., C. burnetii, and T. gondii by RT-PCR/PCR and detected nucleic acids of Tula hantavirus, Leptospira spp., Borrelia afzelii, Rickettsia spp., and different Bartonella species. Serological investigations were performed for hantaviruses, lymphocytic choriomeningitis virus, orthopox viruses, and Rickettsia spp. Here, Dobrava-Belgrade hantavirus-, Tula hantavirus-, lymphocytic choriomeningitis virus-, orthopox virus-, and rickettsia-specific antibodies were demonstrated. Puumala hantavirus, C. burnetii, and T. gondii were neither detected by RT-PCR/PCR nor by serological methods. In addition, multiple infections with up to three pathogens were shown in nine animals of three rodent species from different trapping sites. In conclusion, these results show that rodents in Austria may host multiple zoonotic pathogens. Our observation raises important questions regarding the interactions of different pathogens in the host, the countermeasures of the host's immune system, the impact of the host-pathogen interaction on the fitness of the host, and the spread of infectious agents among wild rodents and from those to other animals or humans.

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“…In Europe, different rodent-borne hantavirus species have been detected: Dobrava virus (DOBV), Saarema virus (SAAV or DOBV-Aa), Seoul virus (SEOV), Puumala virus (PUUV) and Tula virus (TULV) (Vapalahti et al, 2003). However, there is an ongoing discussion about the classification of SAAV (Klempa et al, 2013). All hantavirus species have their own main reservoir rodent species Reusken & Heyman, 2013;Vapalahti et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Characterization of Puumala hantavirus in bank voles from two regions in the Netherlands where human cases occurred

Vries

Vennema

Bekker³

et al. 2016

Journal of General Virology

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Puumala hantavirus (PUUV) is the most common and widespread hantavirus in Europe and is associated with a mild form of haemorrhagic fever with renal syndrome in humans, called nephropathia epidemica. This study presents the molecular characterization of PUUV circulating in bank voles in two regions of the Netherlands. Most human cases of hantavirus infection are from these two regions. Phylogenetic analysis of the (partial) S, M and Lsegments indicated that the Dutch strains belong to the CE lineage, which includes PUUV strains from France, Germany and Belgium. We have identified two distinct groups of PUUV, corresponding with their geographic origin and with adjoining regions in neighbouring countries.

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Complex evolution and epidemiology of Dobrava-Belgrade hantavirus: definition of genotypes and their characteristics

Cited by 103 publications

References 77 publications

The broad spectrum of hantaviruses and their hosts in Central Europe

The broad spectrum of hantaviruses and their hosts in Central Europe

Multiple Infections of Rodents with Zoonotic Pathogens in Austria

Characterization of Puumala hantavirus in bank voles from two regions in the Netherlands where human cases occurred

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