2024
DOI: 10.21203/rs.3.rs-5366833/v1
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Complex Hydrogen Bonding Leads to Cooperativity Between Antiparallel Polyproline Ii Helices

Douglas Laurents,
Rubén López Sánchez,
Miguel Mompeán

Abstract: Hydrogen bond cooperativity (HBC) is the phenomenon where the collective strengthening of hydrogen bonds in a network exceeds the sum of individual interactions due to mutual polarization and non-additive electrostatic effects. HBC has been well-studied in traditional protein secondary structures such as α-helices and β-sheets, where it critically stabilizes amyloid structures. In the last 20 years, several natural proteins have been characterized which contain several aligned and hydrogen-bonded polyproline I… Show more

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