2013
DOI: 10.1523/jneurosci.3454-12.2013
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Complex Movement Topography and Extrinsic Space Representation in the Rat Forelimb Motor Cortex as Defined by Long-Duration Intracortical Microstimulation

Abstract: Electrical stimulation of the motor cortex in the rat can evoke complex forelimb multi-joint movements, including movement of limb and paw. In this study, these movements have been quantified in terms of 3D displacement and kinematic variables of two markers positioned on the wrist and middle digits (limb and paw movement, respectively). Electrical microstimulation was applied to the motor cortex using a pulse train of 500 ms duration. Movements were measured using a high-resolution 3D optical system. Five cla… Show more

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Cited by 65 publications
(65 citation statements)
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“…These results are consistent with the observation that the forepaw-tomouth movement had a constant goal position and that defensive-like and locomotion-like movements included oscillatory components. We also mapped elements of the ethologically relevant movements, and obtained similar results to those observed in studies of rodents (Ramanathan et al, 2006;Komiyama et al, 2010;Bonazzi et al, 2013;Fig. 7 E, F ).…”
Section: Ethologically Relevant Movements Induced By Ptossupporting
confidence: 78%
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“…These results are consistent with the observation that the forepaw-tomouth movement had a constant goal position and that defensive-like and locomotion-like movements included oscillatory components. We also mapped elements of the ethologically relevant movements, and obtained similar results to those observed in studies of rodents (Ramanathan et al, 2006;Komiyama et al, 2010;Bonazzi et al, 2013;Fig. 7 E, F ).…”
Section: Ethologically Relevant Movements Induced By Ptossupporting
confidence: 78%
“…Most mapping experiments so far have used anesthetized rodents, in which natural behaviors were substantially suppressed (Ramanathan et al, 2006;Bonazzi et al, 2013;Silasi et al, 2013;Brown and Teskey, 2014), because it has been difficult to stably monitor forelimb movements in awake ones. By contrast, in the present study, awake, head-fixed mice were accustomed to a condition where their forelimbs were off the ground.…”
Section: Discussionmentioning
confidence: 99%
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“…4D; Tennant et al, 2011). Parcellation of motor cortex into functionally distinct zones according to the direction of evoked movement has been described for the forelimb in monkeys (Graziano and Aflalo, 2007), rats (Bonazzi et al, 2013), and mice (Harrison et al, 2012). The present data are consistent with these findings: mouse hindlimb motor representation was parceled according to direction of movement, as shown in Figure 4 (1-4 vs 5 and 6 ).…”
Section: Discussionmentioning
confidence: 99%