Complex Regulation of X-Chromosome Inactivation in Mammals by Long Non-coding RNAs

Calabrese, J. Mauro

doi:10.1007/978-3-030-17086-8_1

Cited by 1 publication

(1 citation statement)

References 191 publications

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“…Besides miRNAs, small RNAs also include long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) which are emerging as key regulators implicated in a significant number of biological processes (Qu et al, 2017;Statello et al, 2020). Unlike linear RNAs, circRNAs form a covalently closed continuous loop, without 5 or 3 ends (Qu et al, 2015).…”

Section: Long Non-coding Rnas Regulation In Diabetes-associated Endmtmentioning

confidence: 99%

EndMT Regulation by Small RNAs in Diabetes-Associated Fibrotic Conditions: Potential Link With Oxidative Stress

Giordo

Ahmed

Allam

et al. 2021

Front. Cell Dev. Biol.

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Diabetes-associated complications, such as retinopathy, nephropathy, cardiomyopathy, and atherosclerosis, the main consequences of long-term hyperglycemia, often lead to organ dysfunction, disability, and increased mortality. A common denominator of these complications is the myofibroblast-driven excessive deposition of extracellular matrix proteins. Although fibroblast appears to be the primary source of myofibroblasts, other cells, including endothelial cells, can generate myofibroblasts through a process known as endothelial to mesenchymal transition (EndMT). During EndMT, endothelial cells lose their typical phenotype to acquire mesenchymal features, characterized by the development of invasive and migratory abilities as well as the expression of typical mesenchymal products such as α-smooth muscle actin and type I collagen. EndMT is involved in many chronic and fibrotic diseases and appears to be regulated by complex molecular mechanisms and different signaling pathways. Recent evidence suggests that small RNAs, in particular microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are crucial mediators of EndMT. Furthermore, EndMT and miRNAs are both affected by oxidative stress, another key player in the pathophysiology of diabetic fibrotic complications. In this review, we provide an overview of the primary redox signals underpinning the diabetic-associated fibrotic process. Then, we discuss the current knowledge on the role of small RNAs in the regulation of EndMT in diabetic retinopathy, nephropathy, cardiomyopathy, and atherosclerosis and highlight potential links between oxidative stress and the dyad small RNAs-EndMT in driving these pathological states.

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Section: Long Non-coding Rnas Regulation In Diabetes-associated Endmtmentioning

confidence: 99%

EndMT Regulation by Small RNAs in Diabetes-Associated Fibrotic Conditions: Potential Link With Oxidative Stress

Giordo

Ahmed

Allam

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

Complex Regulation of X-Chromosome Inactivation in Mammals by Long Non-coding RNAs

Cited by 1 publication

References 191 publications

EndMT Regulation by Small RNAs in Diabetes-Associated Fibrotic Conditions: Potential Link With Oxidative Stress

EndMT Regulation by Small RNAs in Diabetes-Associated Fibrotic Conditions: Potential Link With Oxidative Stress

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